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Screen-printed carbon based biosensors and their applications in agri-food safety (2020)
Journal Article
Smart, A., Crew, A., Pemberton, R., Hughes, G., Doran, O., & Hart, J. P. (2020). Screen-printed carbon based biosensors and their applications in agri-food safety. Trends in Analytical Chemistry, 127, https://doi.org/10.1016/j.trac.2020.115898

This review focuses on the ways in which screen-printed carbon electrodes have been tailored with different biorecognition elements, including enzymes, antibodies, and aptamers, often with other modifiers, such as mediators and nanoparticles, to prod... Read More about Screen-printed carbon based biosensors and their applications in agri-food safety.

Novel, rapid, low-cost screen-printed (bio)sensors for the direct analysis of boar taint compounds androstenone and skatole in porcine adipose tissue: Comparison with a high-resolution gas chromatographic method (2019)
Journal Article
Westmacott, K. L., Crew, A. P., Doran, O., & Hart, J. P. (2020). Novel, rapid, low-cost screen-printed (bio)sensors for the direct analysis of boar taint compounds androstenone and skatole in porcine adipose tissue: Comparison with a high-resolution gas chromatographic method. Biosensors and Bioelectronics, 150, https://doi.org/10.1016/j.bios.2019.111837

© 2019 Elsevier B.V. This is the first report on the fabrication, characterisation and application of an electrochemical (bio)sensor system for the simultaneous measurement of skatole and androstenone. A biosensor for androstenone was fabricated usin... Read More about Novel, rapid, low-cost screen-printed (bio)sensors for the direct analysis of boar taint compounds androstenone and skatole in porcine adipose tissue: Comparison with a high-resolution gas chromatographic method.

An electrocatalytic screen-printed amperometric sensor for the selective measurement of thiamine (Vitamin B1) in food supplements (2019)
Journal Article
Smart, A., Westmacott, K. L., Crew, A., Doran, O., & Hart, J. P. (2019). An electrocatalytic screen-printed amperometric sensor for the selective measurement of thiamine (Vitamin B1) in food supplements. Biosensors, 9(3), 98. https://doi.org/10.3390/bios9030098

An electrocatalytic screen-printed sensor has been investigated for the measurement of the biologically important biomolecule vitamin B1 (thiamine) for the first time in food supplements. Under basic conditions, the vitamin was converted to its elect... Read More about An electrocatalytic screen-printed amperometric sensor for the selective measurement of thiamine (Vitamin B1) in food supplements.

Association of single nucleotide polymorphisms in leptin (LEP) and leptin receptor (LEPR) genes with backfat thickness and daily weight gain in Ukrainian Large White pigs (2018)
Journal Article
Balatsky, V., Oliinychenko, Y., Sarantseva, N., Getya, A., Saienko, A., Vovk, V., & Doran, O. (2018). Association of single nucleotide polymorphisms in leptin (LEP) and leptin receptor (LEPR) genes with backfat thickness and daily weight gain in Ukrainian Large White pigs. Livestock Science, 217, 157-161. https://doi.org/10.1016/j.livsci.2018.09.015

© 2018 Elsevier B.V. Leptin (LEP) and leptin receptor (LEPR) genes play an important role in the regulation of fat deposition and other commercially important traits in pigs and this regulation is known to be breed-specific. The aim of the present st... Read More about Association of single nucleotide polymorphisms in leptin (LEP) and leptin receptor (LEPR) genes with backfat thickness and daily weight gain in Ukrainian Large White pigs.

7-Hydroxylation of warfarin is strongly inhibited by sesamin, but not by episesamin, caffeic and ferulic acids in human hepatic microsomes (2018)
Journal Article
Pilipenko, N., Rasmussen, M. K., Doran, O., & Zamaratskaia, G. (2018). 7-Hydroxylation of warfarin is strongly inhibited by sesamin, but not by episesamin, caffeic and ferulic acids in human hepatic microsomes. Food and Chemical Toxicology, 113, 14-18. https://doi.org/10.1016/j.fct.2018.01.020

© 2018 Elsevier Ltd Warfarin is a commonly used anticoagulant drug and is a derivate of coumarin. Cytochrome P450 2C9 (CYP2C9) plays the key role in transformation of coumarin and thus, influences determination of warfarin dosage. A number of factors... Read More about 7-Hydroxylation of warfarin is strongly inhibited by sesamin, but not by episesamin, caffeic and ferulic acids in human hepatic microsomes.

A novel electroanalytical approach to the measurement of B vitamins in food supplements based on screen-printed carbon sensors (2017)
Journal Article
Westmacott, K. L., Crew, A. P., Doran, O., & Hart, J. P. (2018). A novel electroanalytical approach to the measurement of B vitamins in food supplements based on screen-printed carbon sensors. Talanta, 181, 13-18. https://doi.org/10.1016/j.talanta.2017.12.074

© 2017 Elsevier B.V. This paper describes the development of a novel electrochemical assay for the measurement of water-soluble vitamins in food and pharmaceutical products. The optimum conditions for the determination of vitamin B1 (thiamine), B2 (r... Read More about A novel electroanalytical approach to the measurement of B vitamins in food supplements based on screen-printed carbon sensors.

The reduction of starch in finishing diets supplemented with oil does not prevent the accumulation of trans-10 18:1 in lamb meat (2017)
Journal Article
Prates, J. A., Costa, M., Alves, S. P., Francisco, A., Almeida, J., Alfaia, C. M., …Bessa, R. J. (2017). The reduction of starch in finishing diets supplemented with oil does not prevent the accumulation of trans-10 18:1 in lamb meat. Journal of Animal Science, 95(8), 3745-3761. https://doi.org/10.2527/jas.2017.1578

© 2017 American Society of Animal Science. All rights reserved. The experiment was conducted to test the hypothesis that the replacement of cereal with low-starch feed ingredients in lambs’ finishing diets supplemented with oils could prevent the acc... Read More about The reduction of starch in finishing diets supplemented with oil does not prevent the accumulation of trans-10 18:1 in lamb meat.

Polymorphisms of the porcine cathepsins, growth hormone-releasing hormone and leptin receptor genes and their association with meat quality traits in Ukrainian Large White breed (2016)
Journal Article
Balatsky, V., Bankovska, I., Pena, R. N., Saienko, A., Buslyk, T., Korinnyi, S., & Doran, O. (2016). Polymorphisms of the porcine cathepsins, growth hormone-releasing hormone and leptin receptor genes and their association with meat quality traits in Ukrainian Large White breed. Molecular Biology Reports, 43(6), 517-526. https://doi.org/10.1007/s11033-016-3977-z

© 2016, The Author(s). Cathepsins, growth hormone-releasing hormone (GHRH) and leptin receptor (LEPR) genes have been receiving increasing attention as potential markers for meat quality and pig performance traits. This study investigated the allele... Read More about Polymorphisms of the porcine cathepsins, growth hormone-releasing hormone and leptin receptor genes and their association with meat quality traits in Ukrainian Large White breed.

Influence of betaine and arginine supplementation of reduced protein diets on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue of cross-bred pigs (2016)
Journal Article
Prates, J. A., Bessa, R. J., Madeira, M. S., Rolo, E. A., Alfaia, C. M., Pires, V. R., …Prates, J. (2016). Influence of betaine and arginine supplementation of reduced protein diets on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue of cross-bred pigs. British Journal of Nutrition, 115(6), 937-950. https://doi.org/10.1017/S0007114515005218

© The Authors 2016. The isolated or combined effects of betaine and arginine supplementation of reduced protein diets (RPD) on fat content, fatty acid composition and mRNA levels of genes controlling lipid metabolism in pig m. longissimus lumborum an... Read More about Influence of betaine and arginine supplementation of reduced protein diets on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue of cross-bred pigs.

Sensor and method for detecting androstenone or skatole in boar taint (2016)
Patent
Hart, J., Crew, A., McGuire, N., & Doran, O. (2016). Sensor and method for detecting androstenone or skatole in boar taint. EP2966441 A1

The present application is concerned with a sensor system for and a method of detecting, and preferably quantifying, androstenone (CAS Reg.No. 18339-16-7) and/or skatole (CAS Reg. No. 83-34-1), the chemicals associated with boar taint. In a preferred... Read More about Sensor and method for detecting androstenone or skatole in boar taint.

Metabolism of androstenone, 17β-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3β-hydroxysteroid dehydrogenase in this process (2015)
Journal Article
Alemany, M., Chen, G., Bai, Y., Ren, L., Zhu, D., Li, Y., …Doran, O. (2015). Metabolism of androstenone, 17β-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3β-hydroxysteroid dehydrogenase in this process. PLoS ONE, 10(1), https://doi.org/10.1371/journal.pone.0113194

© 2015 Chen et al. Steroids metabolism plays an important role in mammals and contributes to quality of pig meat. The main objective of this study was to identify metabolites of androstenone, 17β-estradiol and dihydrotestosterone using primary cultur... Read More about Metabolism of androstenone, 17β-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3β-hydroxysteroid dehydrogenase in this process.

Combined effects of dietary arginine, leucine and protein levels on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue of crossbred pigs (2014)
Journal Article
Prates, J. A., Bessa, R. J., Alfaia, C. M., Pires, V. M., Madeira, M. S., Madeira, M., …Prates, J. (2014). Combined effects of dietary arginine, leucine and protein levels on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue of crossbred pigs. British Journal of Nutrition, 111(9), 1521-1535. https://doi.org/10.1017/S0007114513004029

The cumulative effects of dietary arginine, leucine and protein levels on fat content, fatty acid composition and mRNA levels of genes controlling lipid metabolism in pig longissimus lumborum muscle and subcutaneous adipose tissue (SAT) were investig... Read More about Combined effects of dietary arginine, leucine and protein levels on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue of crossbred pigs.

Effect of pig breed and dietary protein level on selected fatty acids and stearoyl CoA desaturase protein expression in longissimus muscle and subcutaneouse fat (2013)
Journal Article
Bessa, R., Hughes, R. A., Jeromino, E., Moreira, O. C., Prates, J. A. M., & Doran, O. (2013). Effect of pig breed and dietary protein level on selected fatty acids and stearoyl CoA desaturase protein expression in longissimus muscle and subcutaneouse fat. Journal of Animal Science, 91(9), 4540-4546. https://doi.org/10.2527/jas.2012-5963

Effect of breed on fatty acid composition and lipogenic enzyme abundance in the subcutaneous adipose tissue of pigs (2013)
Journal Article
Marriott, D. T., Chevillon, P., Spencer-Phillips, P. T., & Doran, O. (2013). Effect of breed on fatty acid composition and lipogenic enzyme abundance in the subcutaneous adipose tissue of pigs. Journal of Food Science, 78(8), C1130-C1135. https://doi.org/10.1111/1750-3841.12191

This study investigated the role of lipogenic enzyme expression in breed-specific fat deposition in pigs. Objectives: (i) determine effect of breed on the relative abundance of the key lipogenic enzymes stearoyl-CoA desaturase (SCD), delta-6 desatura... Read More about Effect of breed on fatty acid composition and lipogenic enzyme abundance in the subcutaneous adipose tissue of pigs.

Differential effects of reduced protein diets on fatty acid composition and gene expression in muscle and subcutaneous adipose tissue of Alentejana purebred and Large White ×â Landrace ×â Pietrain crossbred pigs (2013)
Journal Article
Prates, J. A., Pires, V. M., Bessa, R. J., Madeira, M. S., Pires, V., Alfaia, C. M., …Prates, J. (2013). Differential effects of reduced protein diets on fatty acid composition and gene expression in muscle and subcutaneous adipose tissue of Alentejana purebred and Large White ×â Landrace ×â Pietrain crossbred pigs. British Journal of Nutrition, 110(02), 216-229. https://doi.org/10.1017/S0007114512004916

The present study assessed the effect of pig genotype (fatty v. lean) and dietary protein and lysine (Lys) levels (normal v. reduced) on intramuscular fat (IMF) content, subcutaneous adipose tissue (SAT) deposition, fatty acid composition and mRNA le... Read More about Differential effects of reduced protein diets on fatty acid composition and gene expression in muscle and subcutaneous adipose tissue of Alentejana purebred and Large White ×â Landrace ×â Pietrain crossbred pigs.

Trpm8 agonists modulate contraction of the pig urinary bladder (2013)
Journal Article
Parsons, B. A., Drake, M. J., Vahabi, B., Parsons, B. A., Doran, O., Rhodes, A., …Drake, M. (2013). Trpm8 agonists modulate contraction of the pig urinary bladder. Canadian Journal of Physiology and Pharmacology, 91(7), 503-509. https://doi.org/10.1139/cjpp-2012-0406

The transient receptor potential melastin-8 (TRPM8) channel is activated by the "cooling" compounds menthol and icilin. Pathophysiologically, it is implicated in the overactive bladder and bladder cooling reflex, but the activity of TRPM8 in normal b... Read More about Trpm8 agonists modulate contraction of the pig urinary bladder.

Use of whole blood for analysis of disease-associated biomarkers (2013)
Journal Article
McLeod, J., Pemberton, R. M., May, J. E., Pemberton, R., Hart, J. P., McLeod, J. D., …Doran, O. (2013). Use of whole blood for analysis of disease-associated biomarkers. Analytical Biochemistry, 437(1), 59-61. https://doi.org/10.1016/j.ab.2013.02.024

Analyses for diagnosis and monitoring of pathological conditions often rely on blood samples, partly due to relative ease of collection. However, many interfering substances largely preclude the use of whole blood itself, necessitating separation of... Read More about Use of whole blood for analysis of disease-associated biomarkers.

Boar taint: Challenges and opportunities (2013)
Presentation / Conference
Doran, O. (2013, March). Boar taint: Challenges and opportunities. Presented at British Pig Executive Board Workshop for UK Meat Industry

Hepatic lipogenic enzyme expression in pigs is affected by selection for decreased backfat thickness at constant intramuscular fat content (2013)
Journal Article
Doran, O., Muñoz, R., Munoz, R., Estany, J., Tor, M., & Doran, O. (2013). Hepatic lipogenic enzyme expression in pigs is affected by selection for decreased backfat thickness at constant intramuscular fat content. Meat Science, 93(3), 746-751. https://doi.org/10.1016/j.meatsci.2012.11.045

This study investigated (i) whether genetic selection for decreased backfat thickness at constant intramuscular fat (IMF) affects the expression of lipogenic enzymes in pig liver and (ii) whether expression of the hepatic lipogenic enzymes is related... Read More about Hepatic lipogenic enzyme expression in pigs is affected by selection for decreased backfat thickness at constant intramuscular fat content.