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Mitochondria and cell death (2000)
Journal Article
Doran, E., Halestrap, A. P., Doran (nee Udovikova), O., Gillespie, J. P., & O'Toole, A. (2000). Mitochondria and cell death. Biochemical Society Transactions, 28(2), 170-177. https://doi.org/10.1042/bst0280170

Mitochondria play a central role in both apoptosis and necrosis through the opening of the mitochondrial permeability transition pore (MPTP). This is thought to be formed through a Ca2+-triggered conformational change of the adenine nucleotide transl... Read More about Mitochondria and cell death.

Mitochondria and cell death: a pore way to die? (2000)
Journal Article
Halestrap, A., Gillespie, J., O'Toole, A., & Doran (nee Udovikova), O. (2000). Mitochondria and cell death: a pore way to die?. Symposia- Society for Experimental Biology, 52, 65-80

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain (2000)
Journal Article
Owen, M., Doran (nee Udovikova), O., & Halestrap, A. (2000). Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochemical Journal, 348(3), 607-614

Although metformin is widely used for the treatment of non-insulin-dependent diabetes, its mode of action remains unclear. Here we provide evidence that its primary site of action is through a direct inhibition of complex 1 of the respiratory chain.... Read More about Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.