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All Outputs (107)

A Pilot Study Combining a GC-Sensor Device with a Statistical Model for the Identification of Bladder Cancer from Urine Headspace (2013)
Journal Article
Ratcliffe, N., Probert, C. S., Ewen, R., Khalid, T., White, P., De Lacy Costello, B., …Ratcliffe, N. M. (2013). A Pilot Study Combining a GC-Sensor Device with a Statistical Model for the Identification of Bladder Cancer from Urine Headspace. PLoS ONE, 8(7), https://doi.org/10.1371/journal.pone.0069602

There is a need to reduce the number of cystoscopies on patients with haematuria. Presently there are no reliable biomarkers to screen for bladder cancer. In this paper, we evaluate a new simple in-house fabricated, GC-sensor device in the diagnosis... Read More about A Pilot Study Combining a GC-Sensor Device with a Statistical Model for the Identification of Bladder Cancer from Urine Headspace.

The importance of methane breath testing: A review (2013)
Journal Article
Ratcliffe, N. M., De Lacy Costello, B. P., de Lacy Costello, B., Ledochowski, M., & Ratcliffe, N. M. (2013). The importance of methane breath testing: A review. Journal of Breath Research, 7(2), https://doi.org/10.1088/1752-7155/7/2/024001

Sugar malabsorption in the bowel can lead to bloating, cramps, diarrhea and other symptoms of irritable bowel syndrome as well as affecting absorption of other nutrients. The hydrogen breath test is now a well established noninvasive test for assessi... Read More about The importance of methane breath testing: A review.

The use of MS for the investigation of irritable bowel syndrome and inflammatory bowel disease (2013)
Journal Article
Ratcliffe, N. M., de Lacy Costello, B., & Shepherd, S. (2013). The use of MS for the investigation of irritable bowel syndrome and inflammatory bowel disease. Clinical laboratory international, 37, 18-20

Currently, the diagnosis of bowel diseases such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) relies on invasive and expensive procedures. Identification of biomarker-based tests to aid diagnosis is an important area of resea... Read More about The use of MS for the investigation of irritable bowel syndrome and inflammatory bowel disease.

Volatile organic compounds (VOCs) found in urine and stool (2013)
Book Chapter
de Lacy Costello, B., & Ratcliffe, N. M. (2013). Volatile organic compounds (VOCs) found in urine and stool. In A. Amann, & D. Smith (Eds.), Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine (405-462). Elsevier

An Investigation of Fecal Volatile Organic Metabolites in Irritable Bowel Syndrome (2013)
Journal Article
Probert, C. S., de Costello, B. L., Ahmed, I., Greenwood, R., de Lacy Costello, B., Ratcliffe, N. M., & Probert, C. (2013). An Investigation of Fecal Volatile Organic Metabolites in Irritable Bowel Syndrome. PLoS ONE, 8(3), https://doi.org/10.1371/journal.pone.0058204

Diagnosing irritable bowel syndrome (IBS) can be a challenge; many clinicians resort to invasive investigations in order to rule out other diseases and reassure their patients. Volatile organic metabolites (VOMs) are emitted from feces; understanding... Read More about An Investigation of Fecal Volatile Organic Metabolites in Irritable Bowel Syndrome.

Volatiles from oral anaerobes confounding breath biomarker discovery (2013)
Journal Article
De Lacy Costello, B., Khalid, T. Y., Ratcliffe, N. M., Khalid, T., Saad, S., Greenman, J., …Ratcliffe, N. M. (2013). Volatiles from oral anaerobes confounding breath biomarker discovery. Journal of Breath Research, 7(1), https://doi.org/10.1088/1752-7155/7/1/017114

The levels of compounds in exhaled mouth air do not necessarily reflect levels in the systemic circulation as bacteria can bio-transform substrates to produce compounds within the mouth. This should be of concern to researchers measuring breath volat... Read More about Volatiles from oral anaerobes confounding breath biomarker discovery.

Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease (2013)
Journal Article
Probert, C. S., Raman, M., Ahmed, I., Gillevet, P. M., Probert, C., Ratcliffe, N. M., …Rioux, K. P. (2013). Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease. Clinical Gastroenterology and Hepatology, 11(7), 868-875.e3. https://doi.org/10.1016/j.cgh.2013.02.015

BACKGROUND & AIMS: The histopathology of nonalcoholic fatty liver disease (NAFLD) is similar to that of alcoholic liver disease. Colonic bacteria are a source of many metabolic products, including ethanol and other volatile organic compounds (VOC) th... Read More about Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease.

A diagnostic apparatus for analysing a sample to diagnose disease (2012)
Patent
Ratcliffe, N. M., de Lacy Costello, B., Ewen, R., & Probert, C. (2012). A diagnostic apparatus for analysing a sample to diagnose disease. EP2502065 A2 (text from WO2011061308A2)

A diagnostic apparatus (10) for analysing a sample to diagnose disease, the apparatus (10) comprising: a separating element (16) for separating gas derived from the sample into component parts; a sensor arrangement (18) coupled to the separating elem... Read More about A diagnostic apparatus for analysing a sample to diagnose disease.

Method and apparatus for monitoring gas concentration in a fluid (2011)
Patent
Lam, J., Ratcliffe, N. M., & Smith, S. (2011). Method and apparatus for monitoring gas concentration in a fluid. US8081313 B2

A monitor for monitoring gas concentration in an aerospace application is described, one such application being measuring the concentration of oxygen in or next to aviation fuel. The monitor comprises: a substance, the spectroscopic properties of whi... Read More about Method and apparatus for monitoring gas concentration in a fluid.

Dimensional modelling of the fuel outgassing phenomenon: Improving flammability assessment of aircraft fuel tanks (2011)
Journal Article
Harris, A. P., & Ratcliffe, N. M. (2011). Dimensional modelling of the fuel outgassing phenomenon: Improving flammability assessment of aircraft fuel tanks

Fuel outgassing (oxygen evolution) within aircraft fuel tanks presents a serious flammability hazard. Time constants representing oxygen transfer rate, from the fuel into a tank’s ullage, are used to model the effect of outgassing on tank flammabilit... Read More about Dimensional modelling of the fuel outgassing phenomenon: Improving flammability assessment of aircraft fuel tanks.

A diagnostic apparatus for analysing a sample to diagnose disease (2011)
Patent
Ratcliffe, N. M., de Lacy Costello, B., Ewen, R., & Probert, C. (2011). A diagnostic apparatus for analysing a sample to diagnose disease. WO/2011/061308

A diagnostic apparatus (10) for analysing a sample to diagnose disease, the apparatus (10) comprising: a separating element (16) for separating gas derived from the sample into component parts; a sensor arrangement (18) coupled to the separating elem... Read More about A diagnostic apparatus for analysing a sample to diagnose disease.

Functionalized paramagnetic nanoparticles for waste water treatment (2010)
Journal Article
Elder, G. R., Duffield, J. R., Urban, I., Ratcliffe, N. M., & Patton, D. (2010). Functionalized paramagnetic nanoparticles for waste water treatment. Chemical Communications, 46(25), 4583-4585. https://doi.org/10.1039/b925933c

An approach to the design, development and implementation of a new separation technology for use in the decontamination of radioactive waste streams is reported here. Calixarene-crown-6 derivatives with terminal carboxyl groups were synthesised and a... Read More about Functionalized paramagnetic nanoparticles for waste water treatment.

Investigation of the semiochemicals of confused flour beetle Tribolium confusum Jaquelin du Val and grain weevil Sitophilus granarius (L.) in stored wheat grain and flour (2010)
Presentation / Conference
Abuelnnor, N., Jones, P., Ratcliffe, N. M., de Lacy Costello, B., & Spencer-Phillips, P. T. (2010, June). Investigation of the semiochemicals of confused flour beetle Tribolium confusum Jaquelin du Val and grain weevil Sitophilus granarius (L.) in stored wheat grain and flour. Paper presented at 10th International Working Conference on Stored Product Protection, Estoril Congress Center, Portugal

This investigation sets out to identify specific volatile compounds from both flour infested with the confused flour beetle, Tribolium confusum and wheat grain infested with the grain weevil, Sitophilus granarius. These volatiles could help to aid th... Read More about Investigation of the semiochemicals of confused flour beetle Tribolium confusum Jaquelin du Val and grain weevil Sitophilus granarius (L.) in stored wheat grain and flour.

Gas sensor (2010)
Patent
Ratcliffe, N. M., de Lacy Costello, B., & Richards, W. (2010). Gas sensor. EP20080804338

A method of detection of a volatile compound in a gaseous atmosphere comprises irradiating a semiconducting metal oxide material with ultraviolet light, exposing the irradiated material to the gaseous atmosphere and determining the presence of any vo... Read More about Gas sensor.

W1908 diagnostic potential of volatile organic compounds in inflammatory bowel disease (2010)
Journal Article
Ahmed, I., Probert, C., Ratcliffe, N. M., & Greenwood, R. (2010). W1908 diagnostic potential of volatile organic compounds in inflammatory bowel disease

Introduction: Crohn's disease (CD) and ulcerative colitis (UC) are diagnosed using invasive investigations which patients find unpleasant. Non-invasive modalities to asses the clinical course of the disease are yet to be adopted. Volatile organic com... Read More about W1908 diagnostic potential of volatile organic compounds in inflammatory bowel disease.

A pilot study of faecal volatile organic compounds in faeces from cholera patients in Bangladesh to determine their utility in disease diagnosis (2009)
Journal Article
Probert, C. S., Garner, C. E., Smith, S., Bardhan, P. K., & Ratcliffe, N. M. (2009). A pilot study of faecal volatile organic compounds in faeces from cholera patients in Bangladesh to determine their utility in disease diagnosis. Transactions of The Royal Society of Tropical Medicine and Hygiene, 103(11), 1171-1173. https://doi.org/10.1016/j.trstmh.2009.02.004

The aim of this pilot study was to analyse the volatile organic compounds in faecal samples collected from cholera patients in Bangladesh to determine biomarkers that could be used for disease diagnosis. Samples were collected from patients at the In... Read More about A pilot study of faecal volatile organic compounds in faeces from cholera patients in Bangladesh to determine their utility in disease diagnosis.

Analysis of faecal volatile organic compounds in preterm infants who develop necrotising enterocolitis: A pilot study (2009)
Journal Article
Garner, C. E., Ewer, A. K., Elasouad, K., Power, F., Greenwood, R., Ratcliffe, N. M., …Probert, C. S. (2009). Analysis of faecal volatile organic compounds in preterm infants who develop necrotising enterocolitis: A pilot study. Journal of Pediatric Gastroenterology and Nutrition, 49(5), 559-565. https://doi.org/10.1097/MPG.0b013e3181a3bfbc

OBJECTIVE:: To determine differences in the profiles of volatile organic compounds (VOCs) in faecal samples from preterm infants who develop necrotising enterocolitis (NEC) compared with non-NEC controls. MATERIALS AND METHODS:: Daily faecal samples... Read More about Analysis of faecal volatile organic compounds in preterm infants who develop necrotising enterocolitis: A pilot study.

Volatile organic compounds as diagnostic biomarkers in gastrointestinal and liver diseases (2009)
Journal Article
Probert, C. S. J., Khalid, T., Ahmed, I., Johnson, E., Smith, S., & Ratcliffe, N. M. (2009). Volatile organic compounds as diagnostic biomarkers in gastrointestinal and liver diseases. Journal of Gastrointestinal and Liver Diseases, 18(3), 337-343

The assessment of disease activity in various conditions may be performed using a range of different techniques. These include the use of non-invasive tests, such as acute phase inflammatory markers and simple radiological techniques, to more advance... Read More about Volatile organic compounds as diagnostic biomarkers in gastrointestinal and liver diseases.