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APC and AXIN2 are promising biomarker candidates for the early detection of adenomas and hyperplastic polyps (2020)
Journal Article
Almond, S., Anaraki, F., Young, C., Ashrafian Bonab, M., Asadzadeh-Aghdaei, H., Rezvani, H., …Ladomery, M. (2020). APC and AXIN2 are promising biomarker candidates for the early detection of adenomas and hyperplastic polyps. Cancer Informatics, 19, 1-8. https://doi.org/10.1177/1176935120972383

Aberrant activation of the WNT/CTNNB1 pathway is notorious in colorectal cancer (CRC). Here, we demonstrate that the expression of specific and crucial WNT signaling pathway genes is linked to disease progression in colonic adenomatous (AP) and hyper... Read More about APC and AXIN2 are promising biomarker candidates for the early detection of adenomas and hyperplastic polyps.

The differential DNA hypermethylation patterns of 2 microRNA-137 and microRNA-342 locus in early 3 colorectal lesions and tumours (2019)
Journal Article
Kashani, E., Hadizadeh, M., Chaleshi, V., Mirfakhraie, R., Young, C., Savabkar, S., …Ashrafian Bonab, M. (2019). The differential DNA hypermethylation patterns of 2 microRNA-137 and microRNA-342 locus in early 3 colorectal lesions and tumours. Biomolecules, 9(10), https://doi.org/10.3390/biom9100519

Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, representing 13% of all cancers. The role of epigenetics in cancer diagnosis and prognosis is well established. MicroRNAs in particular influence numerous cancer associate... Read More about The differential DNA hypermethylation patterns of 2 microRNA-137 and microRNA-342 locus in early 3 colorectal lesions and tumours.

The application of gene expression profiling in predictions of occult lymph node metastasis in colorectal cancer patients (2018)
Journal Article
Peyravian, N., Larki, P., Gharib, E., Nazemalhosseini-Mojarad, E., Anaraki, F., Young, C., …Zali, M. (2018). The application of gene expression profiling in predictions of occult lymph node metastasis in colorectal cancer patients. Biomedicines, 6(1), 27. https://doi.org/10.3390/biomedicines6010027

A key factor in determining the likely outcome for a patient with colorectal cancer is whether or not the tumour has metastasised to the lymph nodes-information which is also important in assessing any possibilities of lymph node resection so as to i... Read More about The application of gene expression profiling in predictions of occult lymph node metastasis in colorectal cancer patients.

GJA4/connexin 37 mutations correlate with secondary lymphedema following surgery in breast cancer patients (2018)
Journal Article
Hadizadeh, M., Mohaddes Ardebili, S., Salehi, M., Young, C., Mokarian, F., McClellan, J., …Bonab, M. A. (2018). GJA4/connexin 37 mutations correlate with secondary lymphedema following surgery in breast cancer patients. Biomedicines, 6(1), 23. https://doi.org/10.3390/biomedicines6010023

Lymphedema is a condition resulting from mutations in various genes essential for lymphatic development and function, which leads to obstruction of the lymphatic system. Secondary lymphedema is a progressive and incurable condition, most often manife... Read More about GJA4/connexin 37 mutations correlate with secondary lymphedema following surgery in breast cancer patients.

Mapping post-glacial expansions: The peopling of Southwest Asia (2017)
Journal Article
Platt, D. E., Haber, M., Dagher-Kharrat, M. B., Douaihy, B., Khazen, G., Ashrafian Bonab, M., …Zalloua, P. A. (2017). Mapping post-glacial expansions: The peopling of Southwest Asia. Scientific Reports, 7(1), Article 40338. https://doi.org/10.1038/srep40338

Archaeological, palaeontological and geological evidence shows that post-glacial warming released human populations from their various climate-bound refugia. Yet specific connections between these refugia and the timing and routes of post-glacial mig... Read More about Mapping post-glacial expansions: The peopling of Southwest Asia.

An old dog and new tricks: Genetic analysis of a Tudor dog recovered from the Mary Rose wreck (2014)
Journal Article
Zouganelis, G. D., Ogden, R., Nahar, N., Runfola, V., Bonab, M., Ardalan, A., …Scarlett, G. (2014). An old dog and new tricks: Genetic analysis of a Tudor dog recovered from the Mary Rose wreck. Forensic Science International, 245, 51-57. https://doi.org/10.1016/j.forsciint.2014.10.001

© 2014 Elsevier Ireland Ltd. The Tudor warship the Mary Rose sank in the Solent waters between Portsmouth and the Isle of Wight on the 19th of July 1545, whilst engaging a French invasion fleet. The ship was rediscovered in 1971 and between 1979 and... Read More about An old dog and new tricks: Genetic analysis of a Tudor dog recovered from the Mary Rose wreck.

Afghanistan's ethnic groups share a y-chromosomal heritage structured by historical events (2012)
Journal Article
Haber, M., Platt, D. E., Ashrafian Bonab, M., Youhanna, S. C., Soria-Hernanz, D. F., Martínez-Cruz, B., …The Genographic Consortium. (2012). Afghanistan's ethnic groups share a y-chromosomal heritage structured by historical events. PLoS ONE, 7(3), e34288. https://doi.org/10.1371/journal.pone.0034288

Afghanistan has held a strategic position throughout history. It has been inhabited since the Paleolithic and later became a crossroad for expanding civilizations and empires. Afghanistan's location, history, and diverse ethnic groups present a uniqu... Read More about Afghanistan's ethnic groups share a y-chromosomal heritage structured by historical events.

Influences of history, geography, and religion on genetic structure: The Maronites in Lebanon (2010)
Journal Article
Zalloua, P. A., Soria-Hernanz, D. F., Youhanna, S. C., Badro, D. A., Platt, D. E., Haber, M., …Zalloua, P. A. (2011). Influences of history, geography, and religion on genetic structure: The Maronites in Lebanon. European Journal of Human Genetics, 19(3), 334-340. https://doi.org/10.1038/ejhg.2010.177

Cultural expansions, including of religions, frequently leave genetic traces of differentiation and in-migration. These expansions may be driven by complex doctrinal differentiation, together with major population migrations and gene flow. The aim of... Read More about Influences of history, geography, and religion on genetic structure: The Maronites in Lebanon.

Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations (2009)
Journal Article
Hiby, S. E., Ashrafian-Bonab, M., Farrell, L., Single, R. M., Balloux, F., Carrington, M., & Moffett, A. (2010). Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations. Immunogenetics, 62(2), 65-73. https://doi.org/10.1007/s00251-009-0408-5

Killer cell immunoglobulin-like receptors (KIR) gene frequencies vary between populations and contribute to functional variation in immune responses to viruses, autoimmunity and reproductive success. This study describes the frequency distribution of... Read More about Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations.

Geographical structure of the Y-chromosomal genetic landscape of the levant: A coastal-inland contrast (2009)
Journal Article
El-Sibai, M., Platt, D. E., Haber, M., Xue, Y., Youhanna, S. C., Wells, R. S., …The Genographic Consortium, . (2009). Geographical structure of the Y-chromosomal genetic landscape of the levant: A coastal-inland contrast. Annals of Human Genetics, 73(6), 568-581. https://doi.org/10.1111/j.1469-1809.2009.00538.x

We have examined the male-specific phylogeography of the Levant and its surroundings by analyzing Y-chromosomal haplogroup distributions using 5874 samples (885 new) from 23 countries. The diversity within some of these haplogroups was also examined.... Read More about Geographical structure of the Y-chromosomal genetic landscape of the levant: A coastal-inland contrast.

Is urbanization scrambling the genetic structure of human populations? A case study (2006)
Journal Article
Handley, L. J., Ashrafian-Bonab, M., Lawson Handley, L. J., & Balloux, F. (2007). Is urbanization scrambling the genetic structure of human populations? A case study. Heredity, 98(3), 151-156. https://doi.org/10.1038/sj.hdy.6800918

Recent population expansion and increased migration linked to urbanization are assumed to be eroding the genetic structure of human populations. We investigated change in population structure over three generations by analysing both demographic and m... Read More about Is urbanization scrambling the genetic structure of human populations? A case study.