Skip to main content

Research Repository

Advanced Search

All Outputs (153)

Diagnostic accuracy of the NEXUS II head injury clinical decision rule in children. A PREDICT prospective cohort study (2017)
Journal Article
Babl, F., Borland, M., Phillips, N., Kochar, A., Dalton, S., Cheek, J., …Lyttle, M. (2017). Diagnostic accuracy of the NEXUS II head injury clinical decision rule in children. A PREDICT prospective cohort study. Archives of Disease in Childhood, 102(S1), A115-A115. https://doi.org/10.1136/archdischild-2017-313087.286

Aims Clinical decision rules (CDRs) can be applied in Emergency Departments (EDs) to optimise the use of computed tomography (CT) in children with head trauma. The National Emergency X- Radiography Utilisation Study II (NEXUS II) CDR, as amended for... Read More about Diagnostic accuracy of the NEXUS II head injury clinical decision rule in children. A PREDICT prospective cohort study.

Defining mild traumatic brain injury: How classification differs across studies when applied to a large prospective data set. A PREDICT prospective cohort study (2017)
Journal Article
Crowe, L., Lyttle, M., Hearps, S., Anderson, V., Borland, M., Phillips, N., …Babl, F. (2017). Defining mild traumatic brain injury: How classification differs across studies when applied to a large prospective data set. A PREDICT prospective cohort study. Archives of Disease in Childhood, 102(S1), A115-A115. https://doi.org/10.1136/archdischild-2017-313087.287

Aims Mild traumatic brain injury (TBI) in children is a major public health issue, yet there is wide variation in the way ‘mild’ TBI is defined in the literature and in guidelines. To date no study has prospectively detailed the proportion of childre... Read More about Defining mild traumatic brain injury: How classification differs across studies when applied to a large prospective data set. A PREDICT prospective cohort study.

Confirmation of traumatic cardiac arrest in children: A literature review to inform the peruki ptca consensus study (2017)
Journal Article
Ledger, E., & Lyttle, M. (2017). Confirmation of traumatic cardiac arrest in children: A literature review to inform the peruki ptca consensus study. Archives of Disease in Childhood, 102(S1), A118-A118. https://doi.org/10.1136/archdischild-2017-313087.293

Aims Traumatic cardiac arrest (TCA) is associated with high mortality and poor neurological outcomes. Several methods of confirming cardiac arrest are utilised including auscultation of heart sounds, palpation of pulses and echocardiography. We did a... Read More about Confirmation of traumatic cardiac arrest in children: A literature review to inform the peruki ptca consensus study.

Accuracy of physician practice as compared with PECARN, CATCH and CHALICE head injury clinical decision rules in children. A PREDICT prospective cohort study (2017)
Journal Article
Lyttle, M., Borland, M., Phillips, N., Kochar, A., Cheek, J., Gilhotra, Y., …Babl, F. (2017). Accuracy of physician practice as compared with PECARN, CATCH and CHALICE head injury clinical decision rules in children. A PREDICT prospective cohort study. Archives of Disease in Childhood, 102(S1), A107-A108. https://doi.org/10.1136/archdischild-2017-313087.267

Aims Clinical decision rules (CDRs) can assist in determining the need for computed tomography (CT) in children with head injuries (HIs). We assessed the accuracy of 3 high quality CDRs (PECARN, CATCH and CHALICE) in a large prospective cohort of hea... Read More about Accuracy of physician practice as compared with PECARN, CATCH and CHALICE head injury clinical decision rules in children. A PREDICT prospective cohort study.

Paediatric intentional head injuriesin the emergency department. A PREDICT multicentre prospective cohort study (2017)
Journal Article
Pfeiffer, H., Borland, M., Phillips, N., Kochar, A., Dalton, S., Cheek, J., …Babl, F. (2017). Paediatric intentional head injuriesin the emergency department. A PREDICT multicentre prospective cohort study. Archives of Disease in Childhood, 102(S1), A117-A117. https://doi.org/10.1136/archdischild-2017-313087.291

Aims While the majority of head injuries (HIs) in children are non-intentional, there is limited information on intentional HIs outside abusive head trauma. The objective of this study was to describe epidemiology, demographics and severity of intent... Read More about Paediatric intentional head injuriesin the emergency department. A PREDICT multicentre prospective cohort study.

Paediatric traumatic cardiac arrest– A Delphi study to establish consensus on management. A PERUKI study (2017)
Journal Article
Rickard, A., Vassallo, J., Nutbeam, T., Maconochie, I., Lyttle, M., & Smith, J. (2017). Paediatric traumatic cardiac arrest– A Delphi study to establish consensus on management. A PERUKI study. Archives of Disease in Childhood, 102(S1), A108-A108. https://doi.org/10.1136/archdischild-2017-313087.268

Background Paediatric traumatic cardiac arrest (TCA) is associated with low survival and poor outcomes. The mechanisms that underlie TCA are different from medical cardiac arrest; the approach to treatment of TCA may therefore also need to differ to... Read More about Paediatric traumatic cardiac arrest– A Delphi study to establish consensus on management. A PERUKI study.

Epidemiology and aetiology of paediatric traumatic cardiac arrest in england and wales, a peruki study (2017)
Journal Article
Vassallo, J., Webster, M., Barnard, E., Fragoso-Iñiguez, M., Lyttle, M., & Smith, J. (2017). Epidemiology and aetiology of paediatric traumatic cardiac arrest in england and wales, a peruki study. Archives of Disease in Childhood, 102(S1), A116-A116. https://doi.org/10.1136/archdischild-2017-313087.289

Background Traumatic cardiac arrest (TCA) in children has traditionally been described as having a poor outcome. Survival rates vary widely between studies with higher rates observed from mechanisms leading to a respiratory cause of TCA (e.g. drownin... Read More about Epidemiology and aetiology of paediatric traumatic cardiac arrest in england and wales, a peruki study.

Emergency treatment with levetiracetam or phenytoin in status epilepticus in children-the EcLiPSE study: Study protocol for a randomised controlled trial (2017)
Journal Article
Bacon, N. E., Lyttle, M., Gamble, C., Messahel, S., Hickey, H., Iyer, A., …Appleton, R. E. (2017). Emergency treatment with levetiracetam or phenytoin in status epilepticus in children-the EcLiPSE study: Study protocol for a randomised controlled trial. Trials, 18(1), https://doi.org/10.1186/s13063-017-2010-8

© The Author(s). 2017. Background: Convulsive status epilepticus (CSE) is the most common life-threatening neurological emergency in childhood. These children are also at risk of significant morbidity, with acute and chronic impact on the family and... Read More about Emergency treatment with levetiracetam or phenytoin in status epilepticus in children-the EcLiPSE study: Study protocol for a randomised controlled trial.

Ten concerns about blood pressure measurement and targets in paediatric sepsis (2016)
Journal Article
Lyttle, M. D., Marlais, M., Lyttle, M., & Inwald, D. (2017). Ten concerns about blood pressure measurement and targets in paediatric sepsis. Intensive Care Medicine, 43(3), 433-435. https://doi.org/10.1007/s00134-016-4642-7

Current paediatric sepsis guidelines suggest that resuscitation is titrated against clinical markers of hypovolaemia and end organ perfusion [1], including blood pressure (BP), heart rate and capillary refill time (CRT). BP is used both as a defining... Read More about Ten concerns about blood pressure measurement and targets in paediatric sepsis.

A qualitative feasibility study to inform Fluids in Shock (FISH) - a pilot randomised controlled trial of fluid bolus therapy in septic shock (2016)
Journal Article
O'Hara, C., Woolfall, K., Canter, R., Mouncey, P., Rowan, K., Lyttle, M., …Nadel, S. (2016). A qualitative feasibility study to inform Fluids in Shock (FISH) - a pilot randomised controlled trial of fluid bolus therapy in septic shock. Emergency Medicine Journal, 33(12), 902.1-902. https://doi.org/10.1136/emermed-2016-206402.7

Objectives & Background There is increasing evidence that fluid overload may be associated with harm in paediatric critical illness. Fluids in Shock (FiSH) is a combined feasibility and pilot randomised controlled trial (RCT) to determine if restric... Read More about A qualitative feasibility study to inform Fluids in Shock (FISH) - a pilot randomised controlled trial of fluid bolus therapy in septic shock.

Emergency department re-attendances and treatment modifications in young children with uncomplicated community-acquired pneumonia: A PERUKI study (2016)
Journal Article
Bielicki, J., Sharland, M., Lyttle, M., Hartshorn, S., & Petrie, J. (2016). Emergency department re-attendances and treatment modifications in young children with uncomplicated community-acquired pneumonia: A PERUKI study. Emergency Medicine Journal, 33(12), 933.3-934. https://doi.org/10.1136/emermed-2016-206402.62

Objectives & Background Data on the rate of antibiotic retreatment in children with uncomplicated community-acquired pneumonia (CAP) are lacking. We conducted a service evaluation of CAP management to review assumptions for a large UK-based trial p... Read More about Emergency department re-attendances and treatment modifications in young children with uncomplicated community-acquired pneumonia: A PERUKI study.

The transition to clinical expert: Enhanced decision making for children aged less than 5years attending the paediatric ED with acute respiratory conditions (2016)
Journal Article
Lyttle, M. D., Bowen, L., Shaw, A., Lyttle, M., & Purdy, S. (2017). The transition to clinical expert: Enhanced decision making for children aged less than 5years attending the paediatric ED with acute respiratory conditions. Emergency Medicine Journal, 34(2), 76-81. https://doi.org/10.1136/emermed-2015-205211

© Published by the BMJ Publishing Group Limited. Background Rates of unplanned paediatric admissions are persistently high. Many admissions are short-stay events, lasting less than 48 hours. Objective This qualitative research explores factors that i... Read More about The transition to clinical expert: Enhanced decision making for children aged less than 5years attending the paediatric ED with acute respiratory conditions.

A qualitative study of the barriers to procedural sedation practices in paediatric emergency medicine in the UK and Ireland (2016)
Journal Article
Lyttle, M. D., McCoy, S., McCoy, S., Lyttle, M., Hartshorn, S., Larkin, P., …O'Sullivan, R. (2016). A qualitative study of the barriers to procedural sedation practices in paediatric emergency medicine in the UK and Ireland. Emergency Medicine Journal, 33(8), 527-532. https://doi.org/10.1136/emermed-2015-205418

© Published by the BMJ Publishing Group Limited. Introduction There is extensive literature on paediatric procedural sedation (PPS) and its clinical applications in emergency departments (EDs). While numerous guidance and policy documents exist from... Read More about A qualitative study of the barriers to procedural sedation practices in paediatric emergency medicine in the UK and Ireland.

Fifteen-minute consultation: An evidence-based approach to research without prior consent (deferred consent) in neonatal and paediatric critical care trials (2016)
Journal Article
Lyttle, M. D., Woolfall, K., Frith, L., Dawson, A., Gamble, C., Lyttle, M., & Young, B. (2016). Fifteen-minute consultation: An evidence-based approach to research without prior consent (deferred consent) in neonatal and paediatric critical care trials. Archives of Disease in Childhood.education and Practice Edition, 101(1), 49-53. https://doi.org/10.1136/archdischild-2015-309245

G255(P) Psychological interventions for patients of all ages with mild traumatic brain injury: A systematic review (2016)
Journal Article
Creasey, N., & Lyttle, M. (2016). G255(P) Psychological interventions for patients of all ages with mild traumatic brain injury: A systematic review. Archives of Disease in Childhood, 101(S1), A138-A139. https://doi.org/10.1136/archdischild-2016-310863.246

Introduction Head injury is the commonest injury type in UK children accounting for 350,000 Emergency Department attendances every year. While many of these are trivial a significant proportion have a mild traumatic brain injury (mTBI) which is synon... Read More about G255(P) Psychological interventions for patients of all ages with mild traumatic brain injury: A systematic review.

G213 Handlebar Grip Related Injury Prevention (GRIP) feasibility study: Are exposed metal handlebar ends on children’s bikes and scooters a risk factor for serious injury? (2016)
Journal Article
Neilson, A., Hartshorn, S., & Lyttle, M. (2016). G213 Handlebar Grip Related Injury Prevention (GRIP) feasibility study: Are exposed metal handlebar ends on children’s bikes and scooters a risk factor for serious injury?. Archives of Disease in Childhood, 101(S1), A116-A117. https://doi.org/10.1136/archdischild-2016-310863.204

Aims Handlebar-end impact is a well-recognised cause of major intra-abdominal injury in childhood. Through this feasibility study and the associated main study we aim to reduce the incidence and severity these injuries. Proper understanding of risk f... Read More about G213 Handlebar Grip Related Injury Prevention (GRIP) feasibility study: Are exposed metal handlebar ends on children’s bikes and scooters a risk factor for serious injury?.

Psychosocial Care for Injured Children: Worldwide Survey among Hospital Emergency Department Staff (2015)
Journal Article
Lyttle, M. D., Alisic, E., Hoysted, C., Kassam-Adams, N., Landolt, M. A., Curtis, S., …Babl, F. E. (2016). Psychosocial Care for Injured Children: Worldwide Survey among Hospital Emergency Department Staff. Journal of Pediatrics, 170, 227-233.e6. https://doi.org/10.1016/j.jpeds.2015.10.067

© 2016 Elsevier Inc. Objective To examine emergency department (ED) staff's knowledge of traumatic stress in children, attitudes toward providing psychosocial care, and confidence in doing so, and also to examine differences in these outcomes accordi... Read More about Psychosocial Care for Injured Children: Worldwide Survey among Hospital Emergency Department Staff.