All Outputs (4)

Classical structural identifiability methodology applied to low-dimensional dynamic systems in receptor theory (2023)
Journal Article
White, C., Rottschäfer, V., & Bridge, L. (2024). Classical structural identifiability methodology applied to low-dimensional dynamic systems in receptor theory. Journal of Pharmacokinetics and Pharmacodynamics, 51, 39–63. https://doi.org/10.1007/s10928-023-09870-y

Mathematical modelling has become a key tool in pharmacological analysis, towards understanding dynamics of cell signalling and quantifying ligand-receptor interactions. Ordinary differential equation (ODE) models in receptor theory may be used to pa... Read More about Classical structural identifiability methodology applied to low-dimensional dynamic systems in receptor theory.

NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model (2023)
Journal Article
Grätz, L., Sajkowska-Kozielewicz, J. J., Wesslowski, J., Kinsolving, J., Bridge, L. J., Petzold, K., …Kozielewicz, P. (in press). NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model. British Journal of Pharmacology, https://doi.org/10.1111/bph.16090

Background and Purpose: Wnt binding to Frizzleds (FZD) is a crucial step that leads to the initiation of signalling cascades governing multiple processes during embryonic development, stem cell regulation and adult tissue homeostasis. Recent efforts... Read More about NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model.

Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins (2022)
Journal Article
Maqsood, Z., Clark, J. C., Martin, E. M., Cheung, Y. F. H., Morán, L. A., Watson, S. E. T., …Watson, S. P. (2022). Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins. PLoS Computational Biology, 18(11), Article e1010708. https://doi.org/10.1371/journal.pcbi.1010708

The clustering of platelet glycoprotein receptors with cytosolic YxxL and YxxM motifs, including GPVI, CLEC-2 and PEAR1, triggers activation via phosphorylation of the conserved tyrosine residues and recruitment of the tandem SH2 (Src homology 2) dom... Read More about Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins.

Insights into the dynamics of ligand-induced dimerisation via mathematical modelling and analysis (2022)
Journal Article
White, C., Rottschäfer, V., & Bridge, L. (2022). Insights into the dynamics of ligand-induced dimerisation via mathematical modelling and analysis. Journal of Theoretical Biology, 538, 110996. https://doi.org/10.1016/j.jtbi.2021.110996

The vascular endothelial growth factor (VEGF) receptor (VEGFR) system plays a role in cancer and many other diseases. It is widely accepted that VEGFR receptors dimerise in response to VEGF binding. However, analysis of these mechanisms and their imp... Read More about Insights into the dynamics of ligand-induced dimerisation via mathematical modelling and analysis.