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All Outputs (132)

How hydrogen (H2) can support food security: From farm to fork (2024)
Journal Article
Russell, G., Nenov, A., & Hancock, J. T. (2024). How hydrogen (H2) can support food security: From farm to fork. Applied Sciences, 14(7), 2877. https://doi.org/10.3390/app14072877

Molecular hydrogen (H2) is a low-molecular-weight, non-polar and electrochemically neutral substance that acts as an effective antioxidant and cytoprotective agent, with research into the effects of H2 incorporation into the food chain, at various st... Read More about How hydrogen (H2) can support food security: From farm to fork.

An interplay of gases: oxygen and hydrogen in biological systems (2024)
Journal Article
Russell, G., May, J., & Hancock, J. T. (2024). An interplay of gases: oxygen and hydrogen in biological systems. Oxygen, 4(1), 37-52. https://doi.org/10.3390/oxygen4010003

Produced by photosynthesis, oxygen (O2) is a fundamentally important gas in biological systems, playing roles as a terminal electron receptor in respiration and in host defence through the creation of reactive oxygen species (ROS). Hydrogen (H2) play... Read More about An interplay of gases: oxygen and hydrogen in biological systems.

Preharvest application of hydrogen sulfide and nitric oxide improves floral traits and postharvest performance of cut gladiolus inflorescences (2023)
Journal Article
Zulfiqar, F., Moosa, A., Darras, A., Nafees, M., Ashraf, M., Al-Ashkar, I., …Hancock, J. T. (2024). Preharvest application of hydrogen sulfide and nitric oxide improves floral traits and postharvest performance of cut gladiolus inflorescences. Journal of Plant Growth Regulation, 43, 1153–1165. https://doi.org/10.1007/s00344-023-11173-y

Gladiolus is a well-known bulbous plant producing impressive cut spikes. Hydrogen sulfide and nitric oxide are vital signaling molecules for the proper functioning of plant metabolism. Preharvest applications of these molecules to crops have gained a... Read More about Preharvest application of hydrogen sulfide and nitric oxide improves floral traits and postharvest performance of cut gladiolus inflorescences.

The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells (2023)
Journal Article
Russell, G., Thomas, A. D., Nenov, A., Mannings, G., & Hancock, J. T. (2023). The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells. Hydrogen, 4(4), 746-759. https://doi.org/10.3390/hydrogen4040047

Cancer is a leading cause of mortality worldwide. B-cells are a keystone of the adaptive immune response and are essential for the presentation of tumor-associated antigens to various types of T-cells. Approximately 1.5% of global cancer cases, inclu... Read More about The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells.

Nanotechnology improves disease resistance in plants for food security: Applications and challenges (2023)
Journal Article
Munir, N., Gulzar, W., Abideen, Z., Hancock, J. T., El-Keblawy, A., & Radicetti, E. (2023). Nanotechnology improves disease resistance in plants for food security: Applications and challenges. Biocatalysis and Agricultural Biotechnology, 51, Article 102781

Green synthesis of nano-fertilizers is emerging as a potential strategy and could play a crucial role in disease mitigation, diagnosis, or suppression. Different nanoscale devices (nanoparticles, NPs), biosensors, nano-diagnostic kits, nanofabricatio... Read More about Nanotechnology improves disease resistance in plants for food security: Applications and challenges.

Are protein cavities and pockets commonly used by redox active signalling molecules? (2023)
Journal Article
Hancock, J. T. (2023). Are protein cavities and pockets commonly used by redox active signalling molecules?. Plants, 12(14), 2594. https://doi.org/10.3390/plants12142594

It has been well known for a long time that inert gases, such as xenon (Xe), have significant biological effects. As these atoms are extremely unlikely to partake in direct chemical reactions with biomolecules such as proteins, lipids, and nucleic ac... Read More about Are protein cavities and pockets commonly used by redox active signalling molecules?.

Hydrogen incorporation into solvents can improve the extraction of phenolics, ‎flavonoids, anthocyanins, and antioxidants: A case-study using red beetroot (2023)
Journal Article
Alwazeer, D., Allam Elnasanelkasim, M., Çiğdem, A., ‎Engin, T., Kanmaz, H., Adnan Hayaloglu, A., …Hancock, J. T. (in press). Hydrogen incorporation into solvents can improve the extraction of phenolics, ‎flavonoids, anthocyanins, and antioxidants: A case-study using red beetroot. Industrial Crops and Products,

Different methods are used for extracting phytochemicals from plant produce. Some ‎methods require sophisticated and expensive instruments, while others need multiple steps ‎and specialist equipment, leading to an increase in energy, solvents, cost,... Read More about Hydrogen incorporation into solvents can improve the extraction of phenolics, ‎flavonoids, anthocyanins, and antioxidants: A case-study using red beetroot.

The on/off history of hydrogen in medicine: Will the interest persist this time around? (2023)
Journal Article
LeBaron, T. W., Ohno, K., & Hancock, J. T. (2023). The on/off history of hydrogen in medicine: Will the interest persist this time around?. Oxygen, 3(1), 143-162. https://doi.org/10.3390/oxygen3010011

Over 2000 publications including more than 100 human studies seem to indicate that humans have only recently benefited from or known about the medical effects of H2 within the past 15 years. However, we have unknowingly benefited from H2 since the da... Read More about The on/off history of hydrogen in medicine: Will the interest persist this time around?.

The early history of hydrogen and other gases in respiration and biological systems: Revisiting Beddoes, Cavallo, and Davy (2023)
Journal Article
Hancock, J. T., & LeBaron, T. W. (2023). The early history of hydrogen and other gases in respiration and biological systems: Revisiting Beddoes, Cavallo, and Davy. Oxygen, 3(1), 102-119. https://doi.org/10.3390/oxygen3010008

In 2007 a paper in Nature Medicine sparked a new wave of interest in the use of molecular hydrogen (H2) for medical treatments. Since then there has been a flurry of papers looking at a range of medical aspects, from neurodegenerative disease to spor... Read More about The early history of hydrogen and other gases in respiration and biological systems: Revisiting Beddoes, Cavallo, and Davy.

The genetic and biochemical mechanisms underlying cereal seed dormancy (2023)
Journal Article
Jing, S., Tian, Y., Zhang, H., T. Hancock, J., Zhu, Y., & Li, P. (2023). The genetic and biochemical mechanisms underlying cereal seed dormancy. Phyton-International Journal of Experimental Botany, 92(4), 1203-1214. https://doi.org/10.32604/phyton.2023.026305

The crop seeds have been a staple food for humans, and seed yield is important for sustaining agriculture development and enhancing human adaptability to food risks. The phenomenon of pre-harvest sprouting (PHS), caused by seed dormancy deficiency, a... Read More about The genetic and biochemical mechanisms underlying cereal seed dormancy.

The role of Salicylic acid signal in plant growth, development and abiotic stress (2022)
Journal Article
Hu, Y., Zhi, L., Li, P., T. Hancock, J. T., & Hu, X. (2022). The role of Salicylic acid signal in plant growth, development and abiotic stress. Phyton-International Journal of Experimental Botany, 91(12), 2591-2605. https://doi.org/10.32604/PHYTON.2022.023733

In nature, plants are constantly affected by adverse conditions. Unlike animals, plants can resist these adverse stresses only by insisting on their original positions. Stress can be divided into biological stress and abiotic stress, abiotic stress d... Read More about The role of Salicylic acid signal in plant growth, development and abiotic stress.

Research progress and application of plant branching (2022)
Journal Article
Yang, Y., Hu, Y., Li, P., T. Hancock, J., & Hu, X. (2022). Research progress and application of plant branching. Phyton-International Journal of Experimental Botany, 92(3), 679-689. https://doi.org/10.32604/phyton.2023.024904

Plant branching development plays an important role in plant morphogenesis (aboveground plant type), the number and angle of branches are important agronomic characters that determine crop plant type. Effective branches determine the number of panicl... Read More about Research progress and application of plant branching.

Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily (2022)
Journal Article
Hancock, J. T., Russell, G., Craig, T. J., May, J., Morse, H. R., & Stamler, J. S. (2022). Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily. Oxygen, 2(4), 578-590. https://doi.org/10.3390/oxygen2040038

Hydrogen gas (molecular hydrogen, H2) has significant effects in a range of organisms, from plants to humans. Many inert gases have been reported to have similar effects, and such responses may be most pronounced when cells are stressed. Xenon (Xe),... Read More about Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily.

Molecular Hydrogen: The postharvest use in fruits, vegetables and the floriculture industry (2022)
Journal Article
Hancock, J. T., Russell, G., & Stratakos, A. (2022). Molecular Hydrogen: The postharvest use in fruits, vegetables and the floriculture industry. Applied Sciences, 12(20), Article 10448. https://doi.org/10.3390/app122010448

Featured Application: It is proposed here that the use of molecular hydrogen should be considered more widely for the treatment of post-harvest fruits, vegetables and flowers. This can be applied as a gas, or in solution, and costs associated with it... Read More about Molecular Hydrogen: The postharvest use in fruits, vegetables and the floriculture industry.

The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19 (2022)
Journal Article
Russell, G., Thomas, A., Nenov, A., & Hancock, J. (2022). The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19. Medical Research Archives, 10(9), https://doi.org/10.18103/mra.v10i9.3036

Coronavirus Infectious Disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) that emerged as a novel pathogen of global concern in the latter stages of 2019. COVID-19 is a highly contagio... Read More about The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19.

Chemical priming enhances plant tolerance to salt stress (2022)
Journal Article
Zulfiqar, F., Nafees, M., Chen, J., Darras, A., Ferrante, A., Hancock, J. T., …Siddique, K. H. (2022). Chemical priming enhances plant tolerance to salt stress. Frontiers in Plant Science, 13, 946922. https://doi.org/10.3389/fpls.2022.946922

Salt stress severely limits the productivity of crop plants worldwide and its detrimental effects are aggravated by climate change. Due to a significant world population growth, agriculture has expanded to marginal and salinized regions, which usuall... Read More about Chemical priming enhances plant tolerance to salt stress.

Phytochrome B enhances seed germination tolerance to high temperature by reducing S-nitrosylation of HFR1 (2022)
Journal Article
Ying, S., Yang, W., Li, P., Hu, Y., Lu, S., Zhou, Y., …Hu, X. (2022). Phytochrome B enhances seed germination tolerance to high temperature by reducing S-nitrosylation of HFR1. EMBO Reports, Article e54371. https://doi.org/10.15252/embr.202154371

Light and ambient high temperature (HT) have opposite effects on seed germination. Light induces seed germination through activating the photoreceptor phytochrome B (phyB), resulting in the stabilization of the transcription factor HFR1, which in tur... Read More about Phytochrome B enhances seed germination tolerance to high temperature by reducing S-nitrosylation of HFR1.

Editorial for special issue: “Production and role of molecular hydrogen in plants” (2022)
Journal Article
Hancock, J. T. (2022). Editorial for special issue: “Production and role of molecular hydrogen in plants”. Plants, 11(15), e2047. https://doi.org/10.3390/plants11152047

There seems little doubt that hydrogen gas (molecular hydrogen: H2) has significant effects on biological systems, including on plants. H2 can be administered as a gas, but more commonly is applied to plants as a solution which has been bubbled with... Read More about Editorial for special issue: “Production and role of molecular hydrogen in plants”.

Do SNPs in glutathione S-transferase-omega allow predictions of the susceptibility of vertebrates to SARS-CoV-2? (2022)
Journal Article
Hancock, J. T., Veal, D., Craig, T. J., & Rouse, R. C. (2022). Do SNPs in glutathione S-transferase-omega allow predictions of the susceptibility of vertebrates to SARS-CoV-2?. Reactive Oxygen Species, 12, c14–c29. https://doi.org/10.20455/ros.2022.c805

Infection with the SARS-Cov-2 virus causes COVID-19 in humans, and is the cause of the pandemic around the world in 2020 and on. However, some animals have been found to be susceptible to the virus too. This has included the non-human primates, dogs,... Read More about Do SNPs in glutathione S-transferase-omega allow predictions of the susceptibility of vertebrates to SARS-CoV-2?.