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Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator? (2019)
Journal Article
Hancock, J. T., Russell, G., & Veal, D. (in press). Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator?. Reactive Oxygen Species,

D-Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an immensely important enzyme carrying out a vital step in glycolysis and is found in all living organisms. Although there are several isoforms identified in many species, it is now recognized tha... Read More about Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator?.

A forty year journey: The generation and roles of NO in plants (2019)
Journal Article
Kolbert, Z., Barroso, J. B., Brouquisse, R., Corpas, F. J., Gupta, K. J., Lindermayr, C., …Hancock, J. (2019). A forty year journey: The generation and roles of NO in plants. Nitric Oxide: Biology and Chemistry, 93, 53-70. https://doi.org/10.1016/j.niox.2019.09.006

In this year there is the 40th anniversary of the first publication of plant nitric oxide (NO) emission by Lowell Klepper. In the decades since then numerous milestone discoveries have revealed that NO is a multifunctional molecule in plant cells reg... Read More about A forty year journey: The generation and roles of NO in plants.

Recommendations on terminology and experimental best practice associated with plant nitric oxide research (2019)
Journal Article
Gupta, K. J., Hancock, J. T., Petrivalsky, M., Kolbert, Z. S., Lindermayr, C., Durner, J., …John Loake, G. (in press). Recommendations on terminology and experimental best practice associated with plant nitric oxide research. New Phytologist, https://doi.org/10.1111/nph.16157

© 2019 The Authors. New Phytologist © 2019 New Phytologist Trust Nitric oxide (NO) emerged as a key signal molecule in plants. During the last two decades impressive progress has been made in plant NO research. This small, redox-active molecule is no... Read More about Recommendations on terminology and experimental best practice associated with plant nitric oxide research.

Network theory and the resilience of redox signaling (2019)
Journal Article
Hancock, J. T., Veal, D., & Hancock, A. L. (2019). Network theory and the resilience of redox signaling. Reactive Oxygen Species, 8(23), 245-257

The redox status inside and around cells is critically important to control, being used to maintain reduced compounds in the correct state and for cell signaling mechanisms. A myriad of compounds and proteins are involved in a vast network system to... Read More about Network theory and the resilience of redox signaling.

Equations to support redox experimentation (2019)
Book Chapter
Hancock, J., & Whiteman, M. Equations to support redox experimentation. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction, 183-195. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9463-2_15

Working with redox compounds needs to take into account the oxidation and reduction state of the compound under study. This redox state can be influenced by the media in which the compound is found, but will also be influenced by local environments.... Read More about Equations to support redox experimentation.

Methods for the addition of redox Compounds (2019)
Book Chapter
Hancock, J. T. Methods for the addition of redox Compounds. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction, 13-25. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9463-2_2

Often in redox biology experiments there is a need to add compounds which impinge on the redox of the cellular environment cell. Such compounds may include reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), reactive nitrogen species suc... Read More about Methods for the addition of redox Compounds.

Investigating ROS, RNS, and H2S-sensitive signaling proteins (2019)
Book Chapter
Williams, E., Whiteman, M., Wood, M. E., Wilson, I. D., Ladomery, M. R., Allainguillaume, J., …Hancock, J. T. (2019). Investigating ROS, RNS, and H2S-sensitive signaling proteins. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction, (27-42). Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9463-2_3

© Springer Science+Business Media, LLC, part of Springer Nature 2019. The modification of proteins is a key way to alter their activity and function. Often thiols, cysteine residues, on proteins are attractive targets for such modification. Assuming... Read More about Investigating ROS, RNS, and H2S-sensitive signaling proteins.

Predicting the effects of low dose-rate ionizing radiation on redox potential in plant cells (2019)
Book Chapter
Caplin, N., & Willey, N. (2019). Predicting the effects of low dose-rate ionizing radiation on redox potential in plant cells. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction, (135-142). New York, USA: Humana. https://doi.org/10.1007/978-1-4939-9463-2_11

During exposure of cells to acute high dose-rate ionizing radiation (IR), oxidants from the radiolysis of water can overwhelm antioxidant systems. Protecting flora from the effects of IR released from a nuclear industry of increasing global significa... Read More about Predicting the effects of low dose-rate ionizing radiation on redox potential in plant cells.

Considerations of the importance of redox state on reactive nitrogen species action (2019)
Journal Article
Hancock, J. (2019). Considerations of the importance of redox state on reactive nitrogen species action. Journal of Experimental Botany, 70(17), 4323-4331. https://doi.org/10.1093/jxb/erz067

Nitric oxide (NO) and other reactive nitrogen species (RNS) are immensely important signalling molecules in plants, being involved in a range of physiological responses. However, the exact way in which NO fits into signal transduction pathways is not... Read More about Considerations of the importance of redox state on reactive nitrogen species action.

Nitric oxide: Its generation and interactions with other reactive signaling compounds (2019)
Journal Article
Hancock, J. T., & Neill, S. J. (2019). Nitric oxide: Its generation and interactions with other reactive signaling compounds. Plants, 8(2), 41. https://doi.org/10.3390/plants8020041

Nitric oxide (NO) is an immensely important signaling molecule in animals and plants. It is involved in plant reproduction, development, key physiological responses such as stomatal closure, and cell death. One of the controversies of NO metabolism i... Read More about Nitric oxide: Its generation and interactions with other reactive signaling compounds.

The role of redox in signal transduction (2019)
Book Chapter
Hancock, J. T. (2019). The role of redox in signal transduction. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction, (1-11). Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9463-2_1

© Springer Science+Business Media, LLC, part of Springer Nature 2019. It is the functioning of efficient cell signaling which is vital for the survival of cells, whether it is a simple prokaryote or a complex eukaryote, including both animals and pla... Read More about The role of redox in signal transduction.

Hydrogen gas, ROS metabolism and cell signaling: Are hydrogen spin states important? (2018)
Journal Article
Hancock, J. T., & Hancock, T. H. (2018). Hydrogen gas, ROS metabolism and cell signaling: Are hydrogen spin states important?

It is becoming accepted that treatment with hydrogen gas (H2) has profound and often beneficial effects on cells from both animals and plants. Future uses which have been suggested include for cancer treatment, for alleviating symptoms of Parkinson’s... Read More about Hydrogen gas, ROS metabolism and cell signaling: Are hydrogen spin states important?.

Hydrogen sulfide and environmental stresses (2018)
Journal Article
Hancock, J. T. (2019). Hydrogen sulfide and environmental stresses. Environmental and Experimental Botany, 161, 50-56. https://doi.org/10.1016/j.envexpbot.2018.08.034

© 2018 Elsevier B.V. Hydrogen sulfide (H 2 S) is part of a suite of small reactive molecules which are known to be involved in cell signaling events in plants. It is produced by cells, can move around, including through membranes, and can be removed... Read More about Hydrogen sulfide and environmental stresses.

Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation (2018)
Journal Article
Hancock, J., & Whiteman, M. (2018). Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation. Free Radical Biology and Medicine, 120(S1), s9. https://doi.org/10.1016...eeradbiomed.2018.04.040

Growth and maintenance of cells is partly controlled by the production and perception of a range of small relatively reactive molecules, including reactive oxygen species, nitric oxide and hydrogen sulfide: what may be dubbed reactive signaling molec... Read More about Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation.

Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells (2018)
Journal Article
Bowler, E., Porazinski, S., Uzor, S., Thibault, P., Durand, M., Lapointe, E., …Ladomery, M. (2018). Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells. BMC Cancer, 18(1), 355. https://doi.org/10.1186/s12885-018-4227-7

© 2018 The Author(s). Background: Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia on the alternative splicing of cancer as... Read More about Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells.

Signaling through the primary cilium (2018)
Journal Article
Wheway, G., Nazlamova, L., & Hancock, J. T. (2018). Signaling through the primary cilium. Frontiers in Cell and Developmental Biology, 6(FEB), https://doi.org/10.3389/fcell.2018.00008

© 2018 Wheway, Nazlamova and Hancock. The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remainin... Read More about Signaling through the primary cilium.

Cellular redox environment and its influence on redox signalling molecules (2018)
Journal Article
Hancock, J. T., & Whiteman, M. (2018). Cellular redox environment and its influence on redox signalling molecules

The redox potential of a cell’s internal environment is well recognised as important for controlling cellular activities. Both animal and plant cells generate and are exposed to a range of reactive molecules involved in cell signalling, including rea... Read More about Cellular redox environment and its influence on redox signalling molecules.

Identification and functional annotation of genes differentially expressed in the reproductive tissues of the olive tree (Olea europaea L.) through the generation of subtractive libraries (2017)
Journal Article
Alche, J. D., Goldman, M. H., Traverso, J. A., Carmona, R., Zafra, A., Zafra, A., …De Dios Alche, J. (2017). Identification and functional annotation of genes differentially expressed in the reproductive tissues of the olive tree (Olea europaea L.) through the generation of subtractive libraries. Frontiers in Plant Science, 8(1576), https://doi.org/10.3389/fpls.2017.01576

© 2017 Zafra, Carmona, Traverso, Hancock, Goldman, Claros, Hiscock and Alche. The olive tree is a crop of high socio-economical importance in the Mediterranean area. Sexual reproduction in this plant is an essential process, which determines the yiel... Read More about Identification and functional annotation of genes differentially expressed in the reproductive tissues of the olive tree (Olea europaea L.) through the generation of subtractive libraries.