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The early history of hydrogen and other gases in respiration and biological systems: Revisiting Beddoes, Cavallo, and Davy (2023)
Journal Article
Hancock, J. T., & LeBaron, T. W. (2023). The early history of hydrogen and other gases in respiration and biological systems: Revisiting Beddoes, Cavallo, and Davy. Oxygen, 3(1), 102-119. https://doi.org/10.3390/oxygen3010008

In 2007 a paper in Nature Medicine sparked a new wave of interest in the use of molecular hydrogen (H2) for medical treatments. Since then there has been a flurry of papers looking at a range of medical aspects, from neurodegenerative disease to spor... Read More about The early history of hydrogen and other gases in respiration and biological systems: Revisiting Beddoes, Cavallo, and Davy.

The on/off history of hydrogen in medicine: Will the interest persist this time around? (2023)
Journal Article
LeBaron, T. W., Ohno, K., & Hancock, J. T. (in press). The on/off history of hydrogen in medicine: Will the interest persist this time around?. Oxygen,

Over 2000 publications including more than 100 human studies seem to indicate that humans have only recently benefited from or known about the medical effects of H2 within the past 15 years. However, we have unknowingly benefited from H2 since the da... Read More about The on/off history of hydrogen in medicine: Will the interest persist this time around?.

The genetic and biochemical mechanisms underlying cereal seed dormancy (2023)
Journal Article
Jing, S., Tian, Y., Zhang, H., T. Hancock, J., Zhu, Y., & Li, P. (2023). The genetic and biochemical mechanisms underlying cereal seed dormancy. Phyton-International Journal of Experimental Botany, 92(4), 1203-1214. https://doi.org/10.32604/phyton.2023.026305

The crop seeds have been a staple food for humans, and seed yield is important for sustaining agriculture development and enhancing human adaptability to food risks. The phenomenon of pre-harvest sprouting (PHS), caused by seed dormancy deficiency, a... Read More about The genetic and biochemical mechanisms underlying cereal seed dormancy.

The role of Salicylic acid signal in plant growth, development and abiotic stress (2022)
Journal Article
Hu, Y., Zhi, L., Li, P., T. Hancock, J. T., & Hu, X. (2022). The role of Salicylic acid signal in plant growth, development and abiotic stress. Phyton-International Journal of Experimental Botany, 91(12), 2591-2605. https://doi.org/10.32604/PHYTON.2022.023733

In nature, plants are constantly affected by adverse conditions. Unlike animals, plants can resist these adverse stresses only by insisting on their original positions. Stress can be divided into biological stress and abiotic stress, abiotic stress d... Read More about The role of Salicylic acid signal in plant growth, development and abiotic stress.

Research progress and application of plant branching (2022)
Journal Article
Yang, Y., Hu, Y., Li, P., T. Hancock, J., & Hu, X. (2022). Research progress and application of plant branching. Phyton-International Journal of Experimental Botany, 92(3), 679-689. https://doi.org/10.32604/phyton.2023.024904

Plant branching development plays an important role in plant morphogenesis (aboveground plant type), the number and angle of branches are important agronomic characters that determine crop plant type. Effective branches determine the number of panicl... Read More about Research progress and application of plant branching.

Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily (2022)
Journal Article
Hancock, J. T., Russell, G., Craig, T. J., May, J., Morse, H. R., & Stamler, J. S. (2022). Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily. Oxygen, 2(4), 578-590. https://doi.org/10.3390/oxygen2040038

Hydrogen gas (molecular hydrogen, H2) has significant effects in a range of organisms, from plants to humans. Many inert gases have been reported to have similar effects, and such responses may be most pronounced when cells are stressed. Xenon (Xe),... Read More about Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily.

Molecular Hydrogen: The postharvest use in fruits, vegetables and the floriculture industry (2022)
Journal Article
Hancock, J. T., Russell, G., & Stratakos, A. (2022). Molecular Hydrogen: The postharvest use in fruits, vegetables and the floriculture industry. Applied Sciences, 12(20), Article 10448. https://doi.org/10.3390/app122010448

Featured Application: It is proposed here that the use of molecular hydrogen should be considered more widely for the treatment of post-harvest fruits, vegetables and flowers. This can be applied as a gas, or in solution, and costs associated with it... Read More about Molecular Hydrogen: The postharvest use in fruits, vegetables and the floriculture industry.

The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19 (2022)
Journal Article
Russell, G., Thomas, A., Nenov, A., & Hancock, J. (2022). The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19. Medical Research Archives, 10(9), https://doi.org/10.18103/mra.v10i9.3036

Coronavirus Infectious Disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) that emerged as a novel pathogen of global concern in the latter stages of 2019. COVID-19 is a highly contagio... Read More about The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19.

The indirect impact of COVID-19 on the life of animals (2022)
Digital Artefact
Rana, M., Rouse, R., Craig, T. J., Macdonald, H., & Hancock, J. T. (2022). The indirect impact of COVID-19 on the life of animals. [website]

The COVID-19 pandemic is an ongoing major health crisis that is the result of the SARS-CoV-2 virus. The virus was first identified in Wuhan, China during December 2019; many patients were initially reported with pneumonia and later the cause was foun... Read More about The indirect impact of COVID-19 on the life of animals.

Production and Role of Molecular Hydrogen in Plants (2022)
Book
Hancock, J. (Ed.). (2022). Production and Role of Molecular Hydrogen in Plants. MDPI

Molecular hydrogen (hydrogen gas; H2), is gaining prominence in the scientific literature as well as the popular media. Early pre-clinical and clinical studies suggest the use of H2 treatment for a wide range of human diseases, from COVID-19 to vario... Read More about Production and Role of Molecular Hydrogen in Plants.

Chemical priming enhances plant tolerance to salt stress (2022)
Journal Article
Zulfiqar, F., Nafees, M., Chen, J., Darras, A., Ferrante, A., Hancock, J. T., …Siddique, K. H. (2022). Chemical priming enhances plant tolerance to salt stress. Frontiers in Plant Science, 13, 946922. https://doi.org/10.3389/fpls.2022.946922

Salt stress severely limits the productivity of crop plants worldwide and its detrimental effects are aggravated by climate change. Due to a significant world population growth, agriculture has expanded to marginal and salinized regions, which usuall... Read More about Chemical priming enhances plant tolerance to salt stress.

Phytochrome B enhances seed germination tolerance to high temperature by reducing S-nitrosylation of HFR1 (2022)
Journal Article
Ying, S., Yang, W., Li, P., Hu, Y., Lu, S., Zhou, Y., …Hu, X. (2022). Phytochrome B enhances seed germination tolerance to high temperature by reducing S-nitrosylation of HFR1. EMBO Reports, Article e54371. https://doi.org/10.15252/embr.202154371

Light and ambient high temperature (HT) have opposite effects on seed germination. Light induces seed germination through activating the photoreceptor phytochrome B (phyB), resulting in the stabilization of the transcription factor HFR1, which in tur... Read More about Phytochrome B enhances seed germination tolerance to high temperature by reducing S-nitrosylation of HFR1.

Editorial for special issue: “Production and role of molecular hydrogen in plants” (2022)
Journal Article
Hancock, J. T. (2022). Editorial for special issue: “Production and role of molecular hydrogen in plants”. Plants, 11(15), e2047. https://doi.org/10.3390/plants11152047

There seems little doubt that hydrogen gas (molecular hydrogen: H2) has significant effects on biological systems, including on plants. H2 can be administered as a gas, but more commonly is applied to plants as a solution which has been bubbled with... Read More about Editorial for special issue: “Production and role of molecular hydrogen in plants”.

Do SNPs in glutathione S-transferase-omega allow predictions of the susceptibility of vertebrates to SARS-CoV-2? (2022)
Journal Article
Hancock, J. T., Veal, D., Craig, T. J., & Rouse, R. C. (2022). Do SNPs in glutathione S-transferase-omega allow predictions of the susceptibility of vertebrates to SARS-CoV-2?. Reactive Oxygen Species, 12, c14–c29. https://doi.org/10.20455/ros.2022.c805

Infection with the SARS-Cov-2 virus causes COVID-19 in humans, and is the cause of the pandemic around the world in 2020 and on. However, some animals have been found to be susceptible to the virus too. This has included the non-human primates, dogs,... Read More about Do SNPs in glutathione S-transferase-omega allow predictions of the susceptibility of vertebrates to SARS-CoV-2?.

A brief history of Oxygen: 250 years on (2022)
Journal Article
Hancock, J. (2022). A brief history of Oxygen: 250 years on. Oxygen, 2(1), 31-39. https://doi.org/10.3390/oxygen2010004

Although there has been some controversy surrounding exactly when oxygen was first discov-ered, it is likely that that accolade should go to Carl Wilhelm Scheele, who isolated oxygen in 1772, or even a year earlier. Others since then have been given... Read More about A brief history of Oxygen: 250 years on.

Nitric oxide-releasing nanomaterials: From basic research to potential biotechnological applications in agriculture (2022)
Journal Article
Seabra, A. B., Silveira, N. M., Ribeiro, R. V., Pieretti, J. C., Barroso, J. B., Corpas, F. J., …Oliveira, H. C. (2022). Nitric oxide-releasing nanomaterials: From basic research to potential biotechnological applications in agriculture. New Phytologist, 234(4), 1119-1125. https://doi.org/10.1111/nph.18073

Nitric oxide (NO) is a multifunctional gaseous signal that modulates the growth, development and stress tolerance of higher plants. NO donors have been used to boost plant endogenous NO levels and to activate NO-related responses, but this strategy i... Read More about Nitric oxide-releasing nanomaterials: From basic research to potential biotechnological applications in agriculture.

Molecular hydrogen as medicine: An assessment of administration methods (2021)
Journal Article
Russell, G., Nenov, A., Kisher, H., & Hancock, J. T. (2021). Molecular hydrogen as medicine: An assessment of administration methods. Hydrogen, 2(4), 444-460. https://doi.org/10.3390/hydrogen2040025

Since the late 18th century, molecular hydrogen (H2) has been shown to be well tolerated, firstly in animals, and then in humans. However, although research into the beneficial effects of molecular hydrogen in both plant and mammalian physiology is g... Read More about Molecular hydrogen as medicine: An assessment of administration methods.

Molecular hydrogen: Is this a viable new treatment for plants in the UK? (2021)
Journal Article
Hancock, J. T., LeBaron, T. W., May, J., Thomas, A., & Russell, G. (2021). Molecular hydrogen: Is this a viable new treatment for plants in the UK?. Plants, 10(11), Article 2270

Despite being trialed in other regions of the world, the use of molecular hydrogen (H2) for enhanced plant growth and postharvest storage of crops has yet to be widely accepted in the UK. The evidence continues to grow that treatment of plants and pl... Read More about Molecular hydrogen: Is this a viable new treatment for plants in the UK?.

COVID-19 pandemic, eighteen months on: Animals which have been reported to be SARS-CoV-2 positive and impact on animal welfare (2021)
Digital Artefact
Heath, K., Rouse, R., & Hancock, J. T. (2021). COVID-19 pandemic, eighteen months on: Animals which have been reported to be SARS-CoV-2 positive and impact on animal welfare. [Website]

Molecular hydrogen in agriculture (2021)
Journal Article
Zulfiqar, F., Russell, G., & Hancock, J. T. (2021). Molecular hydrogen in agriculture. Planta, 254(3), https://doi.org/10.1007/s00425-021-03706-0

Main conclusion: H2 gas, usually in the form of H2-saturated water, could play a useful role in improving many aspects of plant growth and productivity, including resistance to stress tolerance and improved post-harvest durability. Therefore, molecul... Read More about Molecular hydrogen in agriculture.