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Molecular hydrogen: Redox reactions and possible biological interactions (2021)
Journal Article
Hancock, J. T., LeBaron, T. W., & Russell, G. (in press). Molecular hydrogen: Redox reactions and possible biological interactions. Reactive Oxygen Species,

Molecular hydrogen (H2), either as a gas or as hydrogen-rich water (HRW), is suggested to be a useful treatment for a range of human diseases and also to improve agricultural output. It is often posited that H2 accomplishes its biological action, in... Read More about Molecular hydrogen: Redox reactions and possible biological interactions.

Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases (2021)
Journal Article
Russell, G., Nenov, A., & Hancock, J. (in press). Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases. European Medical Journal,

Oxy-hydrogen gas (HHO) is a gaseous mixture of molecular hydrogen (H2) and molecular oxygen (O2) that is generated by the electrolysis of water and delivered in a 2:1 ratio (66% and 33%, respectively) through the use of non-invasive inhalation device... Read More about Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases.

Interacting proteins, polymorphisms and the susceptibility of animals to SARS-CoV-2 (2021)
Journal Article
Hancock, J., Rouse, R., Stone, E., & Greenhough, A. (2021). Interacting proteins, polymorphisms and the susceptibility of animals to SARS-CoV-2. Animals, 11(3), https://doi.org/10.3390/ani11030797

Abstract: COVID-19, caused by SARS-CoV-2, is a world-wide problem for the human population. It is known that some animal species, such as mink, can become infected and transmit the virus. However, the susceptibility of most animals is not known. Here... Read More about Interacting proteins, polymorphisms and the susceptibility of animals to SARS-CoV-2.

Leaf arginine spraying improves leaf gas exchange under water deficit and root antioxidant responses during the recovery period (2021)
Journal Article
Silveira, N. M., Ribeiro, R. V., de Morais, S. F. N., de Souza, S. C. R., da Silva, S. F., Seabra, A. B., …Machado, E. C. (2021). Leaf arginine spraying improves leaf gas exchange under water deficit and root antioxidant responses during the recovery period. Plant Physiology and Biochemistry, 162, 315-326. https://doi.org/10.1016/j.plaphy.2021.02.036

© 2021 Elsevier Masson SAS Arginine (Arg) metabolism is associated with many cellular and developmental processes in plants and proline, nitric oxide (NO) and polyamines (PAs) have a wide range of physiological functions in plants, including increase... Read More about Leaf arginine spraying improves leaf gas exchange under water deficit and root antioxidant responses during the recovery period.

Downstream signalling from molecular hydrogen (2021)
Journal Article
Hancock, J., & Russell, G. (2021). Downstream signalling from molecular hydrogen. Plants, 10(2), https://doi.org/10.3390/+plants10020367

Molecular hydrogen (H2) is now considered to be a part of the suite of small molecules which can control cellular activity. As such it has been suggested to be used in the therapy of diseases in humans but also to be used in plant science, to enhance... Read More about Downstream signalling from molecular hydrogen.

The effects of seed priming with sodium hydrosulphide on drought tolerance of sunflower (Helianthus annuus L.) in germination and early growth (2020)
Journal Article
Ocvirk, D., Špoljarević, M., Kristić, M., Hancock, J. T., Teklić, T., & Lisjak, M. (2021). The effects of seed priming with sodium hydrosulphide on drought tolerance of sunflower (Helianthus annuus L.) in germination and early growth. Annals of Applied Biology, 178(2), 400-413. https://doi.org/10.1111/aab.12658

© 2020 Association of Applied Biologists Sunflower seeds (hybrid Luka) were primed with water (hydropriming) or sodium hydrosulphide (NaHS) solutions (0.1, 0.5, 1.0 and 1.5 mM NaHS) and subsequently dried to initial moisture content. Unprimed (contro... Read More about The effects of seed priming with sodium hydrosulphide on drought tolerance of sunflower (Helianthus annuus L.) in germination and early growth.

Hydrogenases and the role of molecular hydrogen in plants (2020)
Journal Article
Russell, G., Zulfiqar, F., & Hancock, J. T. (2020). Hydrogenases and the role of molecular hydrogen in plants. Plants, 9(9), 1-15. https://doi.org/10.3390/plants9091136

Molecular hydrogen (H2) has been suggested to be a beneficial treatment for a range of species, from humans to plants. Hydrogenases catalyze the reversible oxidation of H2, and are found in many organisms, including plants. One of the cellular effect... Read More about Hydrogenases and the role of molecular hydrogen in plants.

Hydrogen sulfide in horticulture: Emerging roles in the era of climate change (2020)
Journal Article
Hancock, J. T., Zulfiqar, F., & Hancock, J. (2020). Hydrogen sulfide in horticulture: Emerging roles in the era of climate change. Plant Physiology and Biochemistry, 155, 667-675. https://doi.org/10.1016/j.plaphy.2020.08.010

Future climate change will present many plants with environmental challenges, including extreme temperatures and drought. Hydrogen sulfide (H2S) has emerged as an important signal transmitting molecule in plants, especially important in many stress r... Read More about Hydrogen sulfide in horticulture: Emerging roles in the era of climate change.

Nitric oxide, other reactive signalling compounds, redox and reductive stress (2020)
Journal Article
Hancock, J., & Veal, D. (2021). Nitric oxide, other reactive signalling compounds, redox and reductive stress. Journal of Experimental Botany, 72(3), 819-829. https://doi.org/10.1093/jxb/eraa331

Nitric oxide (NO) and other reactive nitrogen species (RNS) are key signalling molecules in plants, but they do not work in isolation. NO is produced in cells, often increased in response to stress conditions, but many other reactive compounds used i... Read More about Nitric oxide, other reactive signalling compounds, redox and reductive stress.

An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy (2020)
Journal Article
Russell, G., Rehman, M., LeBaron, T. W., Veal, D., Adukwu, E., & Hancock, J. (2020). An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy. Reactive Oxygen Species, 10(28), 150–165

SARS-CoV-2 is an emerging β-coronavirus that causes COVID-19 disease that manifests primarily as a pulmonary infection that can rapidly progress into severe and acute respiratory distress in susceptible patients. Initial reports of severe pulmonary i... Read More about An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy.

Regulating the regulator: nitric oxide control of post-translational modifications (2020)
Journal Article
Gupta, K. J., Kolbert, Z., Durner, J., Lindermayr, C., Corpas, F. J., Brouquisse, R., …Loake, G. J. (2020). Regulating the regulator: nitric oxide control of post-translational modifications. New Phytologist, 227(5), 1319-1325. https://doi.org/10.1111/nph.16622

Nitric oxide (NO) is perfectly suited for the role of a redox signalling molecule. A key route for NO bioactivity occurs via protein S-nitrosation, and involves the addition of a NO moiety to a protein cysteine (Cys) thiol (–SH) to form an S-nitrosot... Read More about Regulating the regulator: nitric oxide control of post-translational modifications.

Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator? (2020)
Journal Article
Russell, G., Veal, D., & Hancock, J. T. (2020). Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator?. Reactive Oxygen Species, 9(26), 48-69

D-Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an immensely important enzyme carrying out a vital step in glycolysis and is found in all living organisms. Although there are several isoforms identified in many species, it is now recognized tha... Read More about Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator?.

Nitric Oxide-Induced Tolerance in Plants under Adverse Environmental Conditions (2019)
Book Chapter
NM, S., B, S., EC, M., JT, H., & RV, R. (2019). Nitric Oxide-Induced Tolerance in Plants under Adverse Environmental Conditions. In T. Islam, H. Oku, M. Fujita, K. Nahar, & M. Hasanuzzaman (Eds.), Approaches for Enhancing Abiotic Stress Tolerance in Plants. , (371-385). Bangladesh: Taylor & Francis

A forty year journey: The generation and roles of NO in plants (2019)
Journal Article
Kolbert, Z., Barroso, J. B., Brouquisse, R., Corpas, F. J., Gupta, K. J., Lindermayr, C., …Hancock, J. (2019). A forty year journey: The generation and roles of NO in plants. Nitric Oxide: Biology and Chemistry, 93, 53-70. https://doi.org/10.1016/j.niox.2019.09.006

In this year there is the 40th anniversary of the first publication of plant nitric oxide (NO) emission by Lowell Klepper. In the decades since then numerous milestone discoveries have revealed that NO is a multifunctional molecule in plant cells reg... Read More about A forty year journey: The generation and roles of NO in plants.

Recommendations on terminology and experimental best practice associated with plant nitric oxide research (2019)
Journal Article
Gupta, K. J., Hancock, J. T., Petrivalsky, M., Kolbert, Z. S., Lindermayr, C., Durner, J., …John Loake, G. (2020). Recommendations on terminology and experimental best practice associated with plant nitric oxide research. New Phytologist, 225(5), 1828-1834. https://doi.org/10.1111/nph.16157

© 2019 The Authors. New Phytologist © 2019 New Phytologist Trust Nitric oxide (NO) emerged as a key signal molecule in plants. During the last two decades impressive progress has been made in plant NO research. This small, redox-active molecule is no... Read More about Recommendations on terminology and experimental best practice associated with plant nitric oxide research.

Network theory and the resilience of redox signaling (2019)
Journal Article
Hancock, J. T., Veal, D., & Hancock, A. L. (2019). Network theory and the resilience of redox signaling. Reactive Oxygen Species, 8(23), 245-257

The redox status inside and around cells is critically important to control, being used to maintain reduced compounds in the correct state and for cell signaling mechanisms. A myriad of compounds and proteins are involved in a vast network system to... Read More about Network theory and the resilience of redox signaling.

Predicting the effects of low dose-rate ionizing radiation on redox potential in plant cells (2019)
Book Chapter
Caplin, N., & Willey, N. (2019). Predicting the effects of low dose-rate ionizing radiation on redox potential in plant cells. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction, (135-142). New York, USA: Humana. https://doi.org/10.1007/978-1-4939-9463-2_11

During exposure of cells to acute high dose-rate ionizing radiation (IR), oxidants from the radiolysis of water can overwhelm antioxidant systems. Protecting flora from the effects of IR released from a nuclear industry of increasing global significa... Read More about Predicting the effects of low dose-rate ionizing radiation on redox potential in plant cells.