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An exploration of the direct biological targets of molecular hydrogen (2024)
Book Chapter
Hancock, J., May, J. E., LeBaron, T. W., Punampalam, R., & Russell, G. (2024). An exploration of the direct biological targets of molecular hydrogen. In J. Slezak, & B. Kura (Eds.), Molecular Hydrogen in Health and Disease (21-38). Springer. https://doi.org/10.1007/978-3-031-47375-3

Molecular hydrogen (H2), supplied either as a gas or in a solution, has been gaining popularity as a treatment for a variety of conditions and diseases. For example, it has been suggested to be beneficial for neurodegenerative diseases, to ease the i... Read More about An exploration of the direct biological targets of molecular hydrogen.

H2S priming and plant abiotic stress tolerance (2023)
Book Chapter
Silveira, N. M., Hancock, J., Machado, E. C., & Ribeiro, R. V. (2023). H2S priming and plant abiotic stress tolerance. In Plant Gasotransmiitters and Molecules with Hormonal Activity (245-262). Elsevier Academic Press. https://doi.org/10.1016/B978-0-323-99035-6.00008-7

Hydrogen sulfide (H2S) is an emerging multitasking signaling molecule involved in plant responses to many abiotic stresses, promoting tolerance and growth under limiting conditions. There is experimental evidence of cross talk between H2S and nitric... Read More about H2S priming and plant abiotic stress tolerance.

Reactive oxygen, nitrogen, and sulfur species cellular crosstalk (2023)
Book Chapter
Ziogas, V., Hancock, J. T., & Corpas, F. J. (2024). Reactive oxygen, nitrogen, and sulfur species cellular crosstalk. In Oxygen, nitrogen, and sulfur species in post-harvest physiology of horticultural crops (247-271). Elsevier Academic Press. https://doi.org/10.1016/B978-0-323-91798-8.00001-1

Accumulating data highlight the fact that nitric oxide (NO), hydrogen sulfide (H2S), and reactive oxygen species (ROS) act as intercellular key signaling molecules in plants. These molecules act in a well-orchestrated manner that regulates cells redo... Read More about Reactive oxygen, nitrogen, and sulfur species cellular crosstalk.

Molecular hydrogen as a beneficial postharvest treatment (2023)
Book Chapter
Hancock, J. T., LeBaron, T. W., May, J., Thomas, A., Zulfiqar, F., & Russell, G. (2024). Molecular hydrogen as a beneficial postharvest treatment. In V. Ziogas, & F. J. Corpas (Eds.), Oxygen, Nitrogen and Sulfur Species in Post-Harvest Physiology of Horticultural Crops (303-318). Elsevier. https://doi.org/10.1016/B978-0-323-91798-8.00011-4

Molecular hydrogen (H2) has been shown to have significant effects in plants, especially during stress responses. H2 treatment can be used as a gas or as an H2-enriched solution, often termed hydrogen-rich water (HRW). Cellular effects of H2 are ofte... Read More about Molecular hydrogen as a beneficial postharvest treatment.

Nitric Oxide-Induced Tolerance in Plants under Adverse Environmental Conditions (2019)
Book Chapter
NM, S., B, S., EC, M., JT, H., & RV, R. (2019). Nitric Oxide-Induced Tolerance in Plants under Adverse Environmental Conditions. In T. Islam, H. Oku, M. Fujita, K. Nahar, & M. Hasanuzzaman (Eds.), Approaches for Enhancing Abiotic Stress Tolerance in Plants. , (371-385). Bangladesh: Taylor & Francis

Equations to support redox experimentation (2019)
Book Chapter
Hancock, J. T., & Whiteman, M. Equations to support redox experimentation. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction (183-195). Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9463-2_15

© Springer Science+Business Media, LLC, part of Springer Nature 2019. Working with redox compounds needs to take into account the oxidation and reduction state of the compound under study. This redox state can be influenced by the media in which the... Read More about Equations to support redox experimentation.

Methods for the addition of redox compounds (2019)
Book Chapter
Hancock, J. T. Methods for the addition of redox compounds. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction (13-25). Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9463-2_2

© Springer Science+Business Media, LLC, part of Springer Nature 2019. Often in redox biology experiments there is a need to add compounds which impinge on the redox of the cellular environment cell. Such compounds may include reactive oxygen species... Read More about Methods for the addition of redox compounds.

Investigating ROS, RNS, and H2S-sensitive signaling proteins (2019)
Book Chapter
Williams, E., Whiteman, M., Wood, M. E., Wilson, I. D., Ladomery, M. R., Allainguillaume, J., …Hancock, J. T. (2019). Investigating ROS, RNS, and H2S-sensitive signaling proteins. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction (27-42). Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9463-2_3

© Springer Science+Business Media, LLC, part of Springer Nature 2019. The modification of proteins is a key way to alter their activity and function. Often thiols, cysteine residues, on proteins are attractive targets for such modification. Assuming... Read More about Investigating ROS, RNS, and H2S-sensitive signaling proteins.

Predicting the effects of low dose-rate ionizing radiation on redox potential in plant cells (2019)
Book Chapter
Caplin, N., & Willey, N. (2019). Predicting the effects of low dose-rate ionizing radiation on redox potential in plant cells. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction, (135-142). New York, USA: Humana. https://doi.org/10.1007/978-1-4939-9463-2_11

During exposure of cells to acute high dose-rate ionizing radiation (IR), oxidants from the radiolysis of water can overwhelm antioxidant systems. Protecting flora from the effects of IR released from a nuclear industry of increasing global significa... Read More about Predicting the effects of low dose-rate ionizing radiation on redox potential in plant cells.

The role of redox in signal transduction (2019)
Book Chapter
Hancock, J. T. (2019). The role of redox in signal transduction. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction (1-11). Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9463-2_1

© Springer Science+Business Media, LLC, part of Springer Nature 2019. It is the functioning of efficient cell signaling which is vital for the survival of cells, whether it is a simple prokaryote or a complex eukaryote, including both animals and pla... Read More about The role of redox in signal transduction.

Nitric oxide signalling in plants (2017)
Book Chapter
Hancock, J. T., Wilson, H. R., & Neill, S. (2017). Nitric oxide signalling in plants. In eLS. Chichester: Wiley. https://doi.org/10.1002/9780470015902.a0020109.pub2

Nitric oxide (NO) is a small simple molecule but one which is instrumental in cell signalling in a range of organisms including plants. It is a gas, often found in the form of a radical. It is produced in cells in an orchestrated manner, usually by d... Read More about Nitric oxide signalling in plants.

Oxidative stress and redox signalling in plants (2016)
Book Chapter
Hancock, J. T. (2016). Oxidative stress and redox signalling in plants. In eLS. Wiley. https://doi.org/10.1002/9780470015902.a0026508

Cell signalling is a critically important aspect of biology, being the mechanism by which organisms, tissues and cells coordinate their activity, and survive environmental change and stress. Numerous bio-molecules are involved but small reactive comp... Read More about Oxidative stress and redox signalling in plants.

Hydrogen sulfide and reactive friends: The interplay with reactive oxygen species and nitric oxide signalling pathways (2015)
Book Chapter
Hancock, J. T., & Whiteman, M. (2015). Hydrogen sulfide and reactive friends: The interplay with reactive oxygen species and nitric oxide signalling pathways. In L. de Kok, M. Hawkesford, H. Rennenberg, & K. Saito (Eds.), Molecular Physiology and Ecophysiology of Sulfur (153-168). Springer. https://doi.org/10.1007/978-3-319-20137-5_16

Hydrogen sulfide (H2S) is now considered to be a signalling molecule in a range of organisms. In animals and plants there are characterised mechanisms for its generation and removal suggesting that it can be made and have an effect when required. In... Read More about Hydrogen sulfide and reactive friends: The interplay with reactive oxygen species and nitric oxide signalling pathways.

Detection of thiol modifications by hydrogen sulfide (2015)
Book Chapter
Williams, E., Pead, S., Whiteman, M., Wood, M. E., Wilson, I. D., Ladomery, M., …Hancock, J. T. (2015). Detection of thiol modifications by hydrogen sulfide. In E. Cadenas, & L. Packer (Eds.), Hydrogen Sulfide in Redox Biology Part B (233-251). UK: Academic Press

Reactive oxygen species, nitric oxide and signal crosstalk (2009)
Book Chapter
Neill, S., Hancock, J. T., & Wilson, I. D. (2009). Reactive oxygen species, nitric oxide and signal crosstalk. In K. Yoshioka, & K. Shinozaki (Eds.), Signal Crosstalk in Plant Stress Responses (136-160). Iowa: Wiley-Blackwell

Tools to investigate reaction oxygen species-sensitive signaling proteins (2009)
Book Chapter
Desikan, R., Neill, S., Slinn, J., & Hancock, J. T. (2009). Tools to investigate reaction oxygen species-sensitive signaling proteins. In J. T. Hancock (Ed.), Redox-Mediated Signal Transduction (84-96). Humana Press. https://doi.org/10.1007/978-1-59745-129-1_7

The thiols groups of cysteine residues on proteins are attractive oxidative targets for modification by reactive oxygen species, such as hydrogen peroxide (H2O2). Such modification can lead to important cellular signaling processes that ultimately re... Read More about Tools to investigate reaction oxygen species-sensitive signaling proteins.

The role of redox in signal transduction (2008)
Book Chapter
Hancock, J. T. (2008). The role of redox in signal transduction. In J. T. Hancock (Ed.), Redox-Mediated Signal Transduction: Methods and Protocols (1-9). Humana Press