Skip to main content

Research Repository

Advanced Search

All Outputs (88)

Preharvest application of hydrogen sulfide and nitric oxide improves floral traits and postharvest performance of cut gladiolus inflorescences (2023)
Journal Article
Zulfiqar, F., Moosa, A., Darras, A., Nafees, M., Ashraf, M., Al-Ashkar, I., …Hancock, J. T. (2024). Preharvest application of hydrogen sulfide and nitric oxide improves floral traits and postharvest performance of cut gladiolus inflorescences. Journal of Plant Growth Regulation, 43, 1153–1165. https://doi.org/10.1007/s00344-023-11173-y

Gladiolus is a well-known bulbous plant producing impressive cut spikes. Hydrogen sulfide and nitric oxide are vital signaling molecules for the proper functioning of plant metabolism. Preharvest applications of these molecules to crops have gained a... Read More about Preharvest application of hydrogen sulfide and nitric oxide improves floral traits and postharvest performance of cut gladiolus inflorescences.

The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells (2023)
Journal Article
Russell, G., Thomas, A. D., Nenov, A., Mannings, G., & Hancock, J. T. (2023). The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells. Hydrogen, 4(4), 746-759. https://doi.org/10.3390/hydrogen4040047

Cancer is a leading cause of mortality worldwide. B-cells are a keystone of the adaptive immune response and are essential for the presentation of tumor-associated antigens to various types of T-cells. Approximately 1.5% of global cancer cases, inclu... Read More about The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells.

Hydrogen incorporation into solvents can improve the extraction of phenolics, ‎flavonoids, anthocyanins, and antioxidants: A case-study using red beetroot (2023)
Journal Article
Alwazeer, D., Allam Elnasanelkasim, M., Çiğdem, A., ‎Engin, T., Kanmaz, H., Adnan Hayaloglu, A., …Hancock, J. T. (in press). Hydrogen incorporation into solvents can improve the extraction of phenolics, ‎flavonoids, anthocyanins, and antioxidants: A case-study using red beetroot. Industrial Crops and Products,

Different methods are used for extracting phytochemicals from plant produce. Some ‎methods require sophisticated and expensive instruments, while others need multiple steps ‎and specialist equipment, leading to an increase in energy, solvents, cost,... Read More about Hydrogen incorporation into solvents can improve the extraction of phenolics, ‎flavonoids, anthocyanins, and antioxidants: A case-study using red beetroot.

The early history of hydrogen and other gases in respiration and biological systems: Revisiting Beddoes, Cavallo, and Davy (2023)
Journal Article
Hancock, J. T., & LeBaron, T. W. (2023). The early history of hydrogen and other gases in respiration and biological systems: Revisiting Beddoes, Cavallo, and Davy. Oxygen, 3(1), 102-119. https://doi.org/10.3390/oxygen3010008

In 2007 a paper in Nature Medicine sparked a new wave of interest in the use of molecular hydrogen (H2) for medical treatments. Since then there has been a flurry of papers looking at a range of medical aspects, from neurodegenerative disease to spor... Read More about The early history of hydrogen and other gases in respiration and biological systems: Revisiting Beddoes, Cavallo, and Davy.

The genetic and biochemical mechanisms underlying cereal seed dormancy (2023)
Journal Article
Jing, S., Tian, Y., Zhang, H., T. Hancock, J., Zhu, Y., & Li, P. (2023). The genetic and biochemical mechanisms underlying cereal seed dormancy. Phyton-International Journal of Experimental Botany, 92(4), 1203-1214. https://doi.org/10.32604/phyton.2023.026305

The crop seeds have been a staple food for humans, and seed yield is important for sustaining agriculture development and enhancing human adaptability to food risks. The phenomenon of pre-harvest sprouting (PHS), caused by seed dormancy deficiency, a... Read More about The genetic and biochemical mechanisms underlying cereal seed dormancy.

Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily (2022)
Journal Article
Hancock, J. T., Russell, G., Craig, T. J., May, J., Morse, H. R., & Stamler, J. S. (2022). Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily. Oxygen, 2(4), 578-590. https://doi.org/10.3390/oxygen2040038

Hydrogen gas (molecular hydrogen, H2) has significant effects in a range of organisms, from plants to humans. Many inert gases have been reported to have similar effects, and such responses may be most pronounced when cells are stressed. Xenon (Xe),... Read More about Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily.

Phytochrome B enhances seed germination tolerance to high temperature by reducing S-nitrosylation of HFR1 (2022)
Journal Article
Ying, S., Yang, W., Li, P., Hu, Y., Lu, S., Zhou, Y., …Hu, X. (2022). Phytochrome B enhances seed germination tolerance to high temperature by reducing S-nitrosylation of HFR1. EMBO Reports, Article e54371. https://doi.org/10.15252/embr.202154371

Light and ambient high temperature (HT) have opposite effects on seed germination. Light induces seed germination through activating the photoreceptor phytochrome B (phyB), resulting in the stabilization of the transcription factor HFR1, which in tur... Read More about Phytochrome B enhances seed germination tolerance to high temperature by reducing S-nitrosylation of HFR1.

Leaf arginine spraying improves leaf gas exchange under water deficit and root antioxidant responses during the recovery period (2021)
Journal Article
Silveira, N. M., Ribeiro, R. V., de Morais, S. F. N., de Souza, S. C. R., da Silva, S. F., Seabra, A. B., …Machado, E. C. (2021). Leaf arginine spraying improves leaf gas exchange under water deficit and root antioxidant responses during the recovery period. Plant Physiology and Biochemistry, 162, 315-326. https://doi.org/10.1016/j.plaphy.2021.02.036

© 2021 Elsevier Masson SAS Arginine (Arg) metabolism is associated with many cellular and developmental processes in plants and proline, nitric oxide (NO) and polyamines (PAs) have a wide range of physiological functions in plants, including increase... Read More about Leaf arginine spraying improves leaf gas exchange under water deficit and root antioxidant responses during the recovery period.

The effects of seed priming with sodium hydrosulphide on drought tolerance of sunflower (Helianthus annuus L.) in germination and early growth (2020)
Journal Article
Ocvirk, D., Špoljarević, M., Kristić, M., Hancock, J. T., Teklić, T., & Lisjak, M. (2021). The effects of seed priming with sodium hydrosulphide on drought tolerance of sunflower (Helianthus annuus L.) in germination and early growth. Annals of Applied Biology, 178(2), 400-413. https://doi.org/10.1111/aab.12658

© 2020 Association of Applied Biologists Sunflower seeds (hybrid Luka) were primed with water (hydropriming) or sodium hydrosulphide (NaHS) solutions (0.1, 0.5, 1.0 and 1.5 mM NaHS) and subsequently dried to initial moisture content. Unprimed (contro... Read More about The effects of seed priming with sodium hydrosulphide on drought tolerance of sunflower (Helianthus annuus L.) in germination and early growth.

Hydrogenases and the role of molecular hydrogen in plants (2020)
Journal Article
Russell, G., Zulfiqar, F., & Hancock, J. T. (2020). Hydrogenases and the role of molecular hydrogen in plants. Plants, 9(9), 1-15. https://doi.org/10.3390/plants9091136

Molecular hydrogen (H2) has been suggested to be a beneficial treatment for a range of species, from humans to plants. Hydrogenases catalyze the reversible oxidation of H2, and are found in many organisms, including plants. One of the cellular effect... Read More about Hydrogenases and the role of molecular hydrogen in plants.

Hydrogen sulfide in horticulture: Emerging roles in the era of climate change (2020)
Journal Article
Zulfiqar, F., & Hancock, J. T. (2020). Hydrogen sulfide in horticulture: Emerging roles in the era of climate change. Plant Physiology and Biochemistry, 155, 667-675. https://doi.org/10.1016/j.plaphy.2020.08.010

Future climate change will present many plants with environmental challenges, including extreme temperatures and drought. Hydrogen sulfide (H2S) has emerged as an important signal transmitting molecule in plants, especially important in many stress r... Read More about Hydrogen sulfide in horticulture: Emerging roles in the era of climate change.

Network theory and the resilience of redox signaling (2019)
Journal Article
Hancock, J. T., Veal, D., & Hancock, A. L. (2019). Network theory and the resilience of redox signaling. Reactive Oxygen Species, 8(23), 245-257

The redox status inside and around cells is critically important to control, being used to maintain reduced compounds in the correct state and for cell signaling mechanisms. A myriad of compounds and proteins are involved in a vast network system to... Read More about Network theory and the resilience of redox signaling.

Considerations of the importance of redox state for reactive nitrogen species action (2019)
Journal Article
Hancock, J. T. (2019). Considerations of the importance of redox state for reactive nitrogen species action. Journal of Experimental Botany, 70(17), 4323-4331. https://doi.org/10.1093/jxb/erz067

Nitric oxide (NO) and other reactive nitrogen species (RNS) are immensely important signalling molecules in plants, being involved in a range of physiological responses. However, the exact way in which NO fits into signal transduction pathways is not... Read More about Considerations of the importance of redox state for reactive nitrogen species action.

Nitric oxide: Its generation and interactions with other reactive signaling compounds (2019)
Journal Article
Hancock, J. T., & Neill, S. J. (2019). Nitric oxide: Its generation and interactions with other reactive signaling compounds. Plants, 8(2), 41. https://doi.org/10.3390/plants8020041

Nitric oxide (NO) is an immensely important signaling molecule in animals and plants. It is involved in plant reproduction, development, key physiological responses such as stomatal closure, and cell death. One of the controversies of NO metabolism i... Read More about Nitric oxide: Its generation and interactions with other reactive signaling compounds.

Hydrogen gas, ROS metabolism and cell signaling: Are hydrogen spin states important? (2018)
Journal Article
Hancock, J. T., & Hancock, T. H. (2018). Hydrogen gas, ROS metabolism and cell signaling: Are hydrogen spin states important?. Reactive Oxygen Species, 6(18),

It is becoming accepted that treatment with hydrogen gas (H2) has profound and often beneficial effects on cells from both animals and plants. Future uses which have been suggested include for cancer treatment, for alleviating symptoms of Parkinson’s... Read More about Hydrogen gas, ROS metabolism and cell signaling: Are hydrogen spin states important?.

Hydrogen sulfide and environmental stresses (2018)
Journal Article
Hancock, J. T. (2019). Hydrogen sulfide and environmental stresses. Environmental and Experimental Botany, 161, 50-56. https://doi.org/10.1016/j.envexpbot.2018.08.034

© 2018 Elsevier B.V. Hydrogen sulfide (H 2 S) is part of a suite of small reactive molecules which are known to be involved in cell signaling events in plants. It is produced by cells, can move around, including through membranes, and can be removed... Read More about Hydrogen sulfide and environmental stresses.

Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation (2018)
Journal Article
Hancock, J., & Whiteman, M. (2018). Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation. Free Radical Biology and Medicine, 120(S1), s9. https://doi.org/10.1016/j.freeradbiomed.2018.04.040

Growth and maintenance of cells is partly controlled by the production and perception of a range of small relatively reactive molecules, including reactive oxygen species, nitric oxide and hydrogen sulfide: what may be dubbed reactive signaling molec... Read More about Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation.

Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells (2018)
Journal Article
Bowler, E., Porazinski, S., Uzor, S., Thibault, P., Durand, M., Lapointe, E., …Ladomery, M. (2018). Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells. BMC Cancer, 18(1), 355. https://doi.org/10.1186/s12885-018-4227-7

© 2018 The Author(s). Background: Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia on the alternative splicing of cancer as... Read More about Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells.

Cellular redox environment and its influence on redox signalling molecules (2018)
Journal Article
Hancock, J. T., & Whiteman, M. (2018). Cellular redox environment and its influence on redox signalling molecules. Reactive Oxygen Species, 5(14),

The redox potential of a cell’s internal environment is well recognised as important for controlling cellular activities. Both animal and plant cells generate and are exposed to a range of reactive molecules involved in cell signalling, including rea... Read More about Cellular redox environment and its influence on redox signalling molecules.