All Outputs (26)

Multiple myeloma: The bone marrow microenvironment and its relation to treatment (2013)
Journal Article
Andrews, S. W., Kabrah, S., May, J. E., Donaldson, C., & Morse, H. R. (2013). Multiple myeloma: The bone marrow microenvironment and its relation to treatment. British Journal of Biomedical Science, 70(3), 110-120. https://doi.org/10.1080/09674845.2013.11669945

Multiple myeloma is the most common haematological malignancy yet currently it remains incurable. For decades the mainstay in therapy has been non-targeted approaches including genotoxic agents and immunosuppressants. With myeloma predominantly affec... Read More about Multiple myeloma: The bone marrow microenvironment and its relation to treatment.

Development of a novel, physiologically relevant cytotoxicity model: Application to the study of chemotherapeutic damage to mesenchymal stromal cells (2012)
Journal Article
May, J. E., Morse, H. R., Xu, J., & Donaldson, C. (2012). Development of a novel, physiologically relevant cytotoxicity model: Application to the study of chemotherapeutic damage to mesenchymal stromal cells. Toxicology and Applied Pharmacology, 263(3), 374-389. https://doi.org/10.1016/j.taap.2012.07.013

There is an increasing need for development of physiologically relevant in-vitro models for testing toxicity, however determining toxic effects of agents which undergo extensive hepatic metabolism can be particularly challenging. If a source of such... Read More about Development of a novel, physiologically relevant cytotoxicity model: Application to the study of chemotherapeutic damage to mesenchymal stromal cells.

Development of a novel, physiologically relevant cytotoxicity model: application to the study of chemotherapeutic damage to mesenchymal stromal cells (2012)
Journal Article
May, J. E., Morse, H. R., Xu, J., & Donaldson, C. (2012). Development of a novel, physiologically relevant cytotoxicity model: application to the study of chemotherapeutic damage to mesenchymal stromal cells. Toxicology and Applied Pharmacology, 263(3), 374-389. https://doi.org/10.1016/j.taap.2012.07.013

Mesenchymal stem cell response to chemotherapeutic damage (2009)
Presentation / Conference
May, J. E., Xu, J., Morse, R., Avent, N. D., Cox, C., Wexler, S. A., & Donaldson, C. (2009, March). Mesenchymal stem cell response to chemotherapeutic damage. Paper presented at 35th Annual meeting EBMT and 25th Meeting of the Nurses Group, Goteborg, Sweden

Mesenchymal stem/stromal cell (MSC) response to chemotherapeutic damage (2009)
Presentation / Conference
May, J. E., Xu, J., Morse, R., Avent, N. D., & Donaldson, C. (2009, January). Mesenchymal stem/stromal cell (MSC) response to chemotherapeutic damage. Paper presented at 3rd United Kingdom Mesenchymal Stem Cell meeting, Sheffield

Toxicity testing: The search for an in vitro alternative to animal testing (2009)
Journal Article
May, J. E., Xu, J., Morse, R., Avent, N. D., & Donaldson, C. (2009). Toxicity testing: The search for an in vitro alternative to animal testing. British Journal of Biomedical Science, 66(3), 160-165. https://doi.org/10.1080/09674845.2009.11730265

Prior to introduction to the clinic, pharmaceuticals must undergo rigorous toxicity testing to ensure their safety. Traditionally, this has been achieved using in vivo animal models. However, besides ethical reasons, there is a continual drive to red... Read More about Toxicity testing: The search for an in vitro alternative to animal testing.