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The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties (2018)
Journal Article
Jumbe, S., Porazinski, S., Oltean, S., Mansell, J., Vahabi, B., Wilson, I., & Ladomery, M. (2019). The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties. Translational Oncology, 12(1), 134-142. https://doi.org/10.1016/j.tranon.2018.09.001

© 2018 The oncogene ERG encodes an ETS family transcription factor and is implicated in blood, vascular, and bone development and in prostate, blood, and bone cancer. The ERG gene is alternatively spliced; of particular interest is its cassette exon... Read More about The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties.

Development and biological evaluation of fluorophosphonate-modified hydroxyapatite for orthopaedic applications (2018)
Journal Article
Neary, G., Blom, A. W., Shiel, A. I., Wheway, G., & Mansell, J. P. (2018). Development and biological evaluation of fluorophosphonate-modified hydroxyapatite for orthopaedic applications. Journal of Materials Science: Materials in Medicine, 29(8), https://doi.org/10.1007/s10856-018-6130-9

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Abstract: There is an incentive to functionalise hydroxyapatite (HA) for orthopaedic implant use with bioactive agents to encourage superior integration of the implants into host... Read More about Development and biological evaluation of fluorophosphonate-modified hydroxyapatite for orthopaedic applications.

Alkaline phosphatase binds tenaciously to titanium; implications for biological surface evaluation following bone implant retrieval (2017)
Journal Article
Stephens, D., Harwood, C., Shiel, A. I., Mansell, J. P., Mansell, J., Shiel, A., …Stephens, D. (2017). Alkaline phosphatase binds tenaciously to titanium; implications for biological surface evaluation following bone implant retrieval. Materials Science and Engineering: C, 76, 472-476. https://doi.org/10.1016/j.msec.2017.03.119

© 2017 Elsevier B.V. Enhancing the performance and longevity of titanium (Ti) implants continues to be a significant developmental theme in contemporary biomaterials design. Our specific focus pertains to the surface functionalisation of Ti using the... Read More about Alkaline phosphatase binds tenaciously to titanium; implications for biological surface evaluation following bone implant retrieval.

Chitinase 3-like 1 expression by human (MG63) osteoblasts in response to lysophosphatidic acid and 1,25-Dihydroxyvitamin D3 (2016)
Journal Article
Mansell, J., Cooke, M., Read, M., Rudd, H., Shiel, A., Wilkins, K., & Manso, M. (2016). Chitinase 3-like 1 expression by human (MG63) osteoblasts in response to lysophosphatidic acid and 1,25-Dihydroxyvitamin D3. Biochimie, 128-9, 193-200. https://doi.org/10.1016/j.biochi.2016.08.011

Chitinase 3-like 1, otherwise known as YKL-40, is a secreted glycoprotein purported to have a role in extracellular matrix metabolism. The first mammalian cell type found to express YKL-40 was the human osteosarcoma-derived osteoblast, MG63. In that... Read More about Chitinase 3-like 1 expression by human (MG63) osteoblasts in response to lysophosphatidic acid and 1,25-Dihydroxyvitamin D3.

Fluorophosphonate-functionalised titanium via a pre-adsorbed alkane phosphonic acid: a novel dual action surface finish for bone regenerative applications (2015)
Journal Article
Mansell, J. P., Ayre, W. N., Scott, T., Hallam, K., Blom, A. W., Denyer, S., …Mansell, J. (2016). Fluorophosphonate-functionalised titanium via a pre-adsorbed alkane phosphonic acid: a novel dual action surface finish for bone regenerative applications. Journal of Materials Science: Materials in Medicine, 27(2), 1-12. https://doi.org/10.1007/s10856-015-5644-7

© 2015, Springer Science+Business Media New York. Abstract: Enhancing vitamin D-induced human osteoblast (hOB) maturation at bone biomaterial surfaces is likely to improve prosthesis integration with resultant reductions in the need for revision art... Read More about Fluorophosphonate-functionalised titanium via a pre-adsorbed alkane phosphonic acid: a novel dual action surface finish for bone regenerative applications.

Dual Action of lysophosphatidate- functionalised titanium: Interactions with human (MG63) osteoblasts and methicillin resistant staphylococcus aureus (2015)
Journal Article
Mansell, J. P., Skindersoe, M. E., Krogfelt, K. A., Blom, A., Zhang, J., Jiang, G., …Mansell, J. (2015). Dual Action of lysophosphatidate- functionalised titanium: Interactions with human (MG63) osteoblasts and methicillin resistant staphylococcus aureus. PLoS ONE, 10(11), e0143509. https://doi.org/10.1371/journal.pone.0143509

© 2015 Skindersoe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are... Read More about Dual Action of lysophosphatidate- functionalised titanium: Interactions with human (MG63) osteoblasts and methicillin resistant staphylococcus aureus.

Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662 (2014)
Journal Article
Blackburn, J., Burston, B., Shepherd, S., Bone, H., Blom, A., & Mansell, J. (2014). Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662

Metformin (Met) is a biguanide drug widely used in the treatment and management of non insulin-dependent diabetes mellitus. In recent years it has emerged that Met, by stimulating adenosine monophosphate-activated protein kinase (AMPK), can promote t... Read More about Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662.

24,25-Dihydroxyvitamin D3 cooperates with a stable, fluoromethylene LPA receptor agonist to secure human (MG63) osteoblast maturation (2014)
Journal Article
Mansell, J. P., Lancaster, S. T., Lancaster, S., Blackburn, J., Blom, A., Makishima, M., …Mansell, J. (2014). 24,25-Dihydroxyvitamin D3 cooperates with a stable, fluoromethylene LPA receptor agonist to secure human (MG63) osteoblast maturation. Steroids, 83, 52-61. https://doi.org/10.1016/j.steroids.2014.01.010

Vitamin D receptor (VDR) agonists supporting human osteoblast (hOB) differentiation in the absence of bone resorption are attractive agents in a bone regenerative setting. One potential candidate fulfilling these roles is 24,25-dihydroxy vitamin D3 (... Read More about 24,25-Dihydroxyvitamin D3 cooperates with a stable, fluoromethylene LPA receptor agonist to secure human (MG63) osteoblast maturation.

Lysophosphatidic acid-functionalised titanium as a superior surface for supporting human osteoblast (MG63) maturation (2012)
Journal Article
Mansell, J. P., Brown, J., Knapp, J., Faur, C., & Blom, A. W. (2012). Lysophosphatidic acid-functionalised titanium as a superior surface for supporting human osteoblast (MG63) maturation. eCells and Materials Journal, 23, 348-361

Covalent modifications of titanium with small molecules known to promote human osteoblast maturation are especially attractive in developing superior biomaterials. An important step in securing competent bone formation at implant sites is promoti... Read More about Lysophosphatidic acid-functionalised titanium as a superior surface for supporting human osteoblast (MG63) maturation.

The emerging role of lysophosphatidic acid (LPA) in skeletal biology (2012)
Journal Article
Mansell, J. P., Blackburn, J., & Mansell, J. P. (2012). The emerging role of lysophosphatidic acid (LPA) in skeletal biology. BONE, 50(3), 756-762. https://doi.org/10.1016/j.bone.2011.12.002

Lysophosphatidic acid (LPA) is the simplest signalling lipid eliciting pleiotropic actions upon most mammalian cell types. Although LPA has an established role in many biological processes, particularly wound healing and cancer, the participation of... Read More about The emerging role of lysophosphatidic acid (LPA) in skeletal biology.

Lysophosphatidic acid and calcitriol co-operate to promote human osteoblastogenesis: Requirement of albumin-bound LPA (2011)
Journal Article
Mansell, J. P., Mansell, J. P., Nowghani, M., Pabbruwe, M., Paterson, I. C., Smith, A. J., & Blom, A. W. (2011). Lysophosphatidic acid and calcitriol co-operate to promote human osteoblastogenesis: Requirement of albumin-bound LPA. Prostaglandins and Other Lipid Mediators, 95(1-4), 45-52. https://doi.org/10.1016...staglandins.2011.05.003

Lysophosphatidic acid (LPA), a pleiotropic signalling lipid is assuming growing significance in osteoblast biology. Although committed osteoblasts from several mammalian species are receptive to LPA far less is known about the potential for LPA to in... Read More about Lysophosphatidic acid and calcitriol co-operate to promote human osteoblastogenesis: Requirement of albumin-bound LPA.

The synergistic effects of lysophosphatidic acid receptor agonists and calcitriol on MG63 osteoblast maturation at titanium and hydroxyapatite surfaces (2010)
Journal Article
Mansell, J. P., Barbour, M., Moore, C., Nowghani, M., Pabbruwe, M., Sjostrom, T., & Blom, A. W. (2010). The synergistic effects of lysophosphatidic acid receptor agonists and calcitriol on MG63 osteoblast maturation at titanium and hydroxyapatite surfaces. Biomaterials, 31(2), 199-206. https://doi.org/10.1016/j.biomaterials.2009.09.035

Successful osseointegration stems from the provision of a mechanically competent mineralised matrix at the implant site. Mature osteoblasts are the cells responsible for achieving this and a key factor for ensuring healthy bone tissue is associated w... Read More about The synergistic effects of lysophosphatidic acid receptor agonists and calcitriol on MG63 osteoblast maturation at titanium and hydroxyapatite surfaces.

Lithocholate-A promising non-calcaemic calcitriol surrogate for promoting human osteoblast maturation upon biomaterials (2009)
Journal Article
Mansell, J. P., Shorez, D., Farrar, D., & Nowghani, M. (2009). Lithocholate-A promising non-calcaemic calcitriol surrogate for promoting human osteoblast maturation upon biomaterials. Steroids, 74(12), 963-970. https://doi.org/10.1016/j.steroids.2009.07.005

Background and aims: Calcitriol, an active vitamin D metabolite, has a limited application in bone repair because of its undesirable hypercalcaemic action. However it has emerged that lithocholic acid (LCA) is a non-calcaemic vitamin D receptor ligan... Read More about Lithocholate-A promising non-calcaemic calcitriol surrogate for promoting human osteoblast maturation upon biomaterials.


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