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A non-contact impedimetric biosensing system for classification of toxins associated with cytotoxicity testing (2020)
Journal Article
Gasser, A., Eveness, J., Kiely, J., Attwood, D., & Luxton, R. (2020). A non-contact impedimetric biosensing system for classification of toxins associated with cytotoxicity testing. Bioelectrochemistry, 133, 107448. https://doi.org/10.1016/j.bioelechem.2019.107448

© 2019 We report on a novel impedance spectroscopy measurement and data analysis technique for cytotoxicity testing. The technique combines non-contact measurement with real-time impedance data analysis based on the toxin dose dependency of the outpu... Read More about A non-contact impedimetric biosensing system for classification of toxins associated with cytotoxicity testing.

Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection (2019)
Journal Article
Barnett, J. M., Monnier, B. M., Tyler, S., West, D., Ballantine-Dykes, H., Regan, E., …Luxton, R. (2020). Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection. Sensing and Bio-Sensing Research, 27, 100315. https://doi.org/10.1016/j.sbsr.2019.100315

© 2019 The resonant coil magnetometer quantifies paramagnetic particles (PMPs) and has been used to develop magneto-immunoassays in a range of formats. The advantage of magneto-immunoassays is that they are relatively inexpensive, portable, easy to p... Read More about Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection.

Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films (2019)
Patent
Cox, T., Kiely, J., Ratcliffe, N., deLacy Costello, B., & Luxton, R. (2019). Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films

The invention relates to the field of sensors for detecting volatile compounds. The sensor of the present invention for detecting volatile compounds comprises: a film of metal oxide; a heater configured to provide heat energy to the film of metal oxi... Read More about Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films.

A copper oxide/zinc oxide composite nano-surface for use in a biosensor (2019)
Journal Article
Cao, L., Kiely, J., Piano, M., & Luxton, R. (2019). A copper oxide/zinc oxide composite nano-surface for use in a biosensor. Materials, 12(7), 1126. https://doi.org/10.3390/ma12071126

© 2019 by the authors. In this study, biosensors based on zinc oxide-copper oxide composite nano-surfaces were prepared using a simple and inexpensive distributed colloidal technique. Combinations of mixed dispersions with volume ratios of 1:1, 1:2 a... Read More about A copper oxide/zinc oxide composite nano-surface for use in a biosensor.

Charge-based supercapacitor storage estimation for indoor sub-mW photovoltaic energy harvesting powered wireless sensor nodes (2019)
Journal Article
Yue, X., Kiely, J., Gibson, D., & Drakakis, E. M. (2020). Charge-based supercapacitor storage estimation for indoor sub-mW photovoltaic energy harvesting powered wireless sensor nodes. IEEE Transactions on Industrial Electronics, 67(3), 2411-2421. https://doi.org/10.1109/TIE.2019.2896321

Supercapacitors offer an attractive energy storage solution for lifetime “fit and forget” photovoltaic (PV) energy harvesting powered wireless sensor nodes for internet of things (IoT) applications. Whilst their low storage capacity is not an issue f... Read More about Charge-based supercapacitor storage estimation for indoor sub-mW photovoltaic energy harvesting powered wireless sensor nodes.

The application of detrended fluctuation analysis to assess physical characteristics of the human cell line ECV304 following toxic challenges (2019)
Journal Article
Djawad, Y. A., Attwood, D., Kiely, J., & Luxton, R. (2019). The application of detrended fluctuation analysis to assess physical characteristics of the human cell line ECV304 following toxic challenges. Sensing and Bio-Sensing Research, 23, 100269. https://doi.org/10.1016/j.sbsr.2019.100269

© 2019 In this paper we present a non-contact, impedance-based sensor system capable of characterizing the toxic response of cells to three different types of toxin. ECV304 cells were treated with 1 mM Hydrogen peroxide, 5% Dimethyl Sulfoxide, and 10... Read More about The application of detrended fluctuation analysis to assess physical characteristics of the human cell line ECV304 following toxic challenges.

Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection (2018)
Journal Article
Lu, C., Janice, K., Martina, P., & Richard, L. (2018). Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection. Scientific Reports, 8(1), 122687. https://doi.org/10.1038/s41598-018-30793-z

© 2018, The Author(s). The paper reports a biosensor formed from antibody coated ZnO nano-crystals which has been prepared using a rapid and inexpensive fabrication method which utilises colloidal dispersion enhanced using sonication. This technique... Read More about Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection.

Mathematical modelling of a magnetic immunoassay (2017)
Journal Article
Luxton, R., Roberts, L., Griffith, T., Champneys, A., Piano, M., Kiely, J., & Luxton, R. W. (2017). Mathematical modelling of a magnetic immunoassay. IMA Journal of Applied Mathematics, 82(6), 1253-1282. https://doi.org/10.1093/imamat/hxx034

© The authors 2017. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved. A mathematical model is developed to describe the action of a novel form of fluidic biosensor that uses para... Read More about Mathematical modelling of a magnetic immunoassay.

Particle facilitate testing (2017)
Patent
Luxton, R. W., Kiely, J., & Wraith, P. (2017). Particle facilitate testing. 2017/0146525A1

Magnetic particles are distributed across a fluid flow by applied magnetic field to interact with a test substance in fluid. Alternatively or additionally, particles, which may be magnetic, are combined with cells and energy, eg ultrasonic energy, is... Read More about Particle facilitate testing.

Enhanced output voltage generation via ZnO nanowires (50nm): Effect of diameter thinning on voltage enhancement (2017)
Journal Article
Luxton, R., Ahmad, M., Iqbal, M. A., Kiely, J., Luxton, R. W., & Jabeen, M. (2017). Enhanced output voltage generation via ZnO nanowires (50nm): Effect of diameter thinning on voltage enhancement. Journal of Physics and Chemistry of Solids, 104, 281-285. https://doi.org/10.1016/j.jpcs.2017.01.006

© 2017 Elsevier Ltd 50nm ZnO nanowires were grown on indium tin oxide (ITO) coated poly ethylene terephthalate (PET) substrates by adapting facile aqueous growth technique using low temperature and vacuum conditions. Prior to growth of ZnO nanowires,... Read More about Enhanced output voltage generation via ZnO nanowires (50nm): Effect of diameter thinning on voltage enhancement.

Facile aqueous growth of 150 nm ZnO nanowires for energy harvester: Enhanced output voltage using Pt sputtered electrode (2015)
Journal Article
Luxton, R., Ahmad, M., Kiely, J., Luxton, R. W., Jabeen, M., & Khalid, M. (2016). Facile aqueous growth of 150 nm ZnO nanowires for energy harvester: Enhanced output voltage using Pt sputtered electrode. Sensing and Bio-Sensing Research, 7, 141-145. https://doi.org/10.1016/j.sbsr.2015.12.005

© 2015. Facile aqueous growth technique was adopted to grow diameter controlled 150 nm ZnO nanowires on an ITO (indium tin oxide) coated PET (poly ethylene terephthalate) substrate. Prior to nanowire growth, a pure wurtazite structured ZnO seed layer... Read More about Facile aqueous growth of 150 nm ZnO nanowires for energy harvester: Enhanced output voltage using Pt sputtered electrode.

A new procedure for analysis and modelling of male urine flow rate (2015)
Presentation / Conference
Li, R., Gammie, A., Zhu, Q., Nibouche, M., & Kiely, J. (2015, July). A new procedure for analysis and modelling of male urine flow rate

In the first stage studies, this paper proposes a new piecewise linear discrete time dynamic model for describing global urine flow rate profiles against time sequence. The establishment of model has been guided by physician meaningful principles and... Read More about A new procedure for analysis and modelling of male urine flow rate.

Low temperature hydrothermal synthesis of ZnO nanowires for nanogenerator: Effect of gold electrode on the output voltage of nanogenerator (2014)
Journal Article
Mansoor, A., Iqbal, M., Kiely, J., & Luxton, R. (2014). Low temperature hydrothermal synthesis of ZnO nanowires for nanogenerator: Effect of gold electrode on the output voltage of nanogenerator. Indian Journal of Engineering and Materials Sciences, 21(6), 672-676

A low temperature hydrothermal technique is developed to grow ZnO (diameter 100 nm) nanowires for high output nanogenerator. Vertically aligned ZnO nanowires are grown on indium tin oxide (ITO) coated poly ethylene terephthalate (PET) substrate. Morp... Read More about Low temperature hydrothermal synthesis of ZnO nanowires for nanogenerator: Effect of gold electrode on the output voltage of nanogenerator.

Lock-in amplifier as a sensitive instrument for biomedical measurement: Analysis and implementation (2014)
Journal Article
Abd Djawad, Y., Kiely, J., Luxton, R., & Wraith, P. (2014). Lock-in amplifier as a sensitive instrument for biomedical measurement: Analysis and implementation

A measuring instrument plays important role in the biomedical measurement since the biological process in living organism generates very weak signal. Therefore, a reliable and sensitive measuring instrument is needed. In this study, a lock-in amplifi... Read More about Lock-in amplifier as a sensitive instrument for biomedical measurement: Analysis and implementation.

An inexpensive, fast and sensitive quantitative lateral flow magneto-immunoassay for total prostate specific antigen (2014)
Journal Article
Luxton, R., Barnett, J. M., Barnett, J., Wraith, P., Kiely, J., Persad, R., …Luxton, R. W. (2014). An inexpensive, fast and sensitive quantitative lateral flow magneto-immunoassay for total prostate specific antigen. Biosensors, 4(3), 204-220. https://doi.org/10.3390/bios4030204

We describe the detection characteristics of a device the Resonant Coil Magnetometer (RCM) to quantify paramagnetic particles (PMPs) in immunochromatographic (lateral flow) assays. Lateral flow assays were developed using PMPs for the measurement of... Read More about An inexpensive, fast and sensitive quantitative lateral flow magneto-immunoassay for total prostate specific antigen.

The dual role of paramagnetic particles for integrated lysis and measurement in a rapid immunoassay for intracellular proteins (2013)
Journal Article
Luxton, R., Sharif, E., Syarif, E., Kiely, J., Wraith, P., & Luxton, R. W. (2013). The dual role of paramagnetic particles for integrated lysis and measurement in a rapid immunoassay for intracellular proteins. IEEE Transactions on Biomedical Engineering, 60(5), 1209-1216. https://doi.org/10.1109/TBME.2012.2228642

A novel, integrated lysis and immunoassay methodology and system for intracellular protein measurement are described. The method uses paramagnetic particles both as a lysis agent and assay label resulting in a rapid test requiring minimal operator in... Read More about The dual role of paramagnetic particles for integrated lysis and measurement in a rapid immunoassay for intracellular proteins.

Novel immunoassay technique for rapid measurement of intracellular proteins using paramagnetic particles (2013)
Journal Article
Sharif, E., Kiely, J., & Luxton, R. (2013). Novel immunoassay technique for rapid measurement of intracellular proteins using paramagnetic particles. Journal of Immunological Methods, 388(1-2), 78-85. https://doi.org/10.1016/j.jim.2012.11.015

Magnetic immunoassays have been shown to have similar detection limits to conventional immunoassays, with the advantage of reduced total assay time. The aim of this study was to demonstrate that an integrated lysis and measurement system could be use... Read More about Novel immunoassay technique for rapid measurement of intracellular proteins using paramagnetic particles.

Robust feature extraction from impedimetric signals using wavelet packet decomposition with application to cytotoxicity testing (2012)
Journal Article
Luxton, R., Wraith, P., Nibouche, M., Kiely, J., Abdul Djawad, Y., Djawad, Y. A., …Luxton, R. W. (2012). Robust feature extraction from impedimetric signals using wavelet packet decomposition with application to cytotoxicity testing. IET Science Measurement and Technology, 6(6), 456-463. https://doi.org/10.1049/iet-smt.2012.0009

Impedance-based cytotoxicity testing provides a simple, real-time and non-invasive assay technique that interferes minimally with cell morphology and function. In this study, impedimetric measurements of ECV304 cells with increasing concentrations of... Read More about Robust feature extraction from impedimetric signals using wavelet packet decomposition with application to cytotoxicity testing.

Non-linear data analysis of impedance spectroscopy as applied to cellular toxicity systems (2012)
Presentation / Conference
Wang, Z., Kiely, J., & Luxton, R. W. (2012, June). Non-linear data analysis of impedance spectroscopy as applied to cellular toxicity systems. Paper presented at International Conference on Modelling, Identification & Control (ICMIC), 2012

This paper introduces an impedance measurement system that can be performed non-destructively to detect cellular toxicity with a cell culture system. This study examines ECV304 cells grown in culture well and exposed to toxicant dimethyl sulphoxide... Read More about Non-linear data analysis of impedance spectroscopy as applied to cellular toxicity systems.

Comparison of cytotoxic changes in ECV304 cell through exposure to DMSO and sodium butyrate using impedance spectroscopy (2012)
Journal Article
Wang, Z., Kiely, J., Vargas, A. M., & Luxton, R. W. (2012). Comparison of cytotoxic changes in ECV304 cell through exposure to DMSO and sodium butyrate using impedance spectroscopy. Procedia Chemistry, 6, 89-99. https://doi.org/10.1016/j.proche.2012.10.134

This paper decides an impedance spectroscopy measurement system for real-time monitoring of cellular toxicity. The system is used to compare the impedance response of ECV304 cells to two toxicants, dimethyl sulphoxide (DMSO) and sodium butyrate. The... Read More about Comparison of cytotoxic changes in ECV304 cell through exposure to DMSO and sodium butyrate using impedance spectroscopy.