All Outputs (21)

A brief overview of the impact of avian influenza on animals (2024)
Journal Article

Avian influenza (AI) virus, and the (HPAI)H5N1 subtype in particular, is a serious problem for many wild bird populations, where devastating losses have been reported. However, AI is not restricted to bird species. Infection has been reported in comm... Read More about A brief overview of the impact of avian influenza on animals.

The control of waterborne pathogenic bacteria in fresh water using a biologically active filter (2022)
Journal Article

The aim of this study was to investigate the control of three species of bacteria commonly associated with biologically contaminated water, using biofiltration. In this study, a laboratory-scale biofilter system was used to investigate the control of... Read More about The control of waterborne pathogenic bacteria in fresh water using a biologically active filter.

Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected (2021)
Journal Article

Tumour microenvironments are hallmarked in many cancer types. In haematological malignancies, bone marrow (BM) mesenchymal stromal cells (MSC) protect malignant cells from drug-induced cytotoxicity. However, less is known about malignant impact on su... Read More about Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected.

Leukaemic and bone marrow stromal cells alter cytarabine genotoxicity and cytotoxicity in favour of disease (2019)
Presentation / Conference Contribution

Resistance to therapy remains one of the greatest challenges in the management of the blood and bone marrow (BM) disorder, acute myeloid leukaemia (AML). This study aimed to investigate how leukaemic and BM stromal cells contribute to altered chemo-s... Read More about Leukaemic and bone marrow stromal cells alter cytarabine genotoxicity and cytotoxicity in favour of disease.

Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML). (2019)
Presentation / Conference Contribution

Mesenchymal stromal cells (MSC) are known to protect leukemic cells from drug-induced toxicity within the bone marrow (BM) niche, however, less is known about leukemic impact on supportive MSC. The nucleoside-analogue, cytarabine (Ara-C), is a front-... Read More about Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML)..

CPX-351 exhibits hENT-independent uptake and can be potentiated by fludarabine in leukaemic cells lines and primary refractory AML (2018)
Journal Article

© 2018 Elsevier Ltd CPX-351, a liposomal formulation co-encapsulating cytarabine and daunorubicin (DNR) in a synergistic 5:1 M ratio, has shown favourable response in newly diagnosed elderly high-risk AML. This study assessed intracellular ara-CTP le... Read More about CPX-351 exhibits hENT-independent uptake and can be potentiated by fludarabine in leukaemic cells lines and primary refractory AML.

Development of a 2D leukaemia-stroma model for analyses of chemo-toxicity protection using a novel bacterial bioluminescent biosensor (2017)
Presentation / Conference Contribution

This study aimed to develop a 2D leukaemia-stroma model of the bone marrow for analysis of stromal-mediated chemo-protection; known to contribute to chemotherapy resistance. The model must facilitate integration of a bioluminescent biosensor HA1 for... Read More about Development of a 2D leukaemia-stroma model for analyses of chemo-toxicity protection using a novel bacterial bioluminescent biosensor.

Cytotoxicity and genotoxicity of electrochemically activated solutions (ECAS) (2017)
Presentation / Conference Contribution

Electrochemically activated solutions (ECAS) are of interest as potential disinfectants due to high biocidal activity against many microorganisms. They are widely used clinically in some countries (decontamination of surgical instruments and wounds),... Read More about Cytotoxicity and genotoxicity of electrochemically activated solutions (ECAS).

Dual species biofilm culture of Staphylococcus aureus and a bioluminescent strain of Pseudomonas aeruginosa (2016)
Presentation / Conference Contribution

Poster presentation.

Introduction
Pseudomonas aeruginosa and Staphylococcus aureus are significant pathogens of wounds and the cystic fibrosis lung. There are likely to be complex interactions between the two species, with biofilm co-culture aff... Read More about Dual species biofilm culture of Staphylococcus aureus and a bioluminescent strain of Pseudomonas aeruginosa.

Low light optical detection of whole-cell bioluminescent bacterial bioreporters for visualisation of surface decontamination using nonthermal plasma (2013)
Presentation / Conference Contribution

Introduction:
Maintenance of a clean, uncontaminated healthcare environment is instrumental in the delivery of modern healthcare. Nonthermal plasma is a technology with potential applications for sterilisation and disinfection in biological and medi... Read More about Low light optical detection of whole-cell bioluminescent bacterial bioreporters for visualisation of surface decontamination using nonthermal plasma.

Comparative antimicrobial activities of aerosolized sodium hypochlorite, chlorine dioxide, and electrochemically activated solutions evaluated using a novel standardized assay (2013)
Journal Article

The main aim of this study was to develop a standardized experimental assay to enable differential antimicrobial comparisons of test biocidal aerosols. This study represents the first chlorine-matched comparative assessment of the antimicrobial activ... Read More about Comparative antimicrobial activities of aerosolized sodium hypochlorite, chlorine dioxide, and electrochemically activated solutions evaluated using a novel standardized assay.

Detection of intracellular ara-C/ara-CTP following treatment with the new anti-leukemic drug elacytarabine using a bioluminescent bacterial biosensor (2013)
Presentation / Conference Contribution

Cytarabine (ara-C) is an analogue of deoxycytidine with an established role in treating AML. Cytarabine depends on the human equilibrative nucleoside transporter-1 (hENT-1) for cellular entry (1). Loss of hENT-1 function in vitro has been shown to re... Read More about Detection of intracellular ara-C/ara-CTP following treatment with the new anti-leukemic drug elacytarabine using a bioluminescent bacterial biosensor.

The effect of long-term storage on the physiochemical and bactericidal properties of electrochemically activated solutions (2013)
Journal Article

Electrochemically activated solutions (ECAS) are generated by electrolysis of NaCl solutions, and demonstrate broad spectrum antimicrobial activity and high environmental compatibility. The biocidal efficacy of ECAS at the point of production is wide... Read More about The effect of long-term storage on the physiochemical and bactericidal properties of electrochemically activated solutions.

Electrochemically activated solutions: Evidence for antimicrobial efficacy and applications in healthcare environments (2012)
Journal Article

Due to the limitations associated with the use of existing biocidal agents, there is a need to explore new methods of disinfection to help maintain effective bioburden control, especially within the healthcare environment. The transformation of low m... Read More about Electrochemically activated solutions: Evidence for antimicrobial efficacy and applications in healthcare environments.

Application of bacterial bioluminescence to assess the efficacy of fast-acting biocides (2011)
Journal Article

Traditional microbiological techniques are used to provide reliable data on the rate and extent of kill for a range of biocides. However, such techniques provide very limited data regarding the initial rate of kill of fast-acting biocides over very s... Read More about Application of bacterial bioluminescence to assess the efficacy of fast-acting biocides.

The use of bioluminescent bacterial spores as a rapid reporter of successful decontamination (2011)
Presentation / Conference Contribution

The efficacy of aerosolised electrochemically activated solutions for rapid decontamination (2011)
Presentation / Conference Contribution

Bacterial bioluminescence as a tool for monitoring the real-time activity of antimicrobial agents (2010)
Presentation / Conference Contribution

Evaluation of the efficacy of electrochemically activated solutions against nosocomial pathogens and bacterial endospores (2010)
Journal Article

Aims: Electrochemically activated solutions (ECAS) are generated from halide salt solutions via specially designed electrolytic cells. The active solutions are known to possess high biocidal activity against a wide range of target microbial species,... Read More about Evaluation of the efficacy of electrochemically activated solutions against nosocomial pathogens and bacterial endospores.

Monitoring the real-time in situ decontamination of surfaces and objects using bacterial bioluminescence (2009)
Presentation / Conference Contribution