Skip to main content

Research Repository

Advanced Search

All Outputs (4)

A high-throughput genome-wide siRNA screen for ciliogenesis identifies new ciliary functional components and ciliopathy genes (2015)
Journal Article
Nguyen, T. M., Wheway, G., Szymanska, K., Wheway, G., Doherty, D., Schmidts, M., …Johnson, C. (2015). A high-throughput genome-wide siRNA screen for ciliogenesis identifies new ciliary functional components and ciliopathy genes. Cilia, 4(SUPPLEMENT 1), O12. https://doi.org/10.1186/2046-2530-4-S1-O12

Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe the first whole genome siRNA-based reverse genetics screen for defects in biogenesis and/or maintenance of the primary cilium, obtaining... Read More about A high-throughput genome-wide siRNA screen for ciliogenesis identifies new ciliary functional components and ciliopathy genes.

The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway (2015)
Journal Article
Abdelhamed, Z. A., Natarajan, S., Wheway, G., Inglehearn, C. F., Toomes, C., Johnson, C. A., & Jagger, D. J. (2015). The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway. Disease Models and Mechanisms, 8(6), 527-541. https://doi.org/10.1242/dmm.019083

© 2015. Published by The Company of Biologists Ltd. Ciliopathies are a group of developmental disorders that manifest with multi-organ anomalies. Mutations in TMEM67 (MKS3) cause a range of human ciliopathies, including Meckel-Gruber and Joubert synd... Read More about The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway.

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes (2015)
Journal Article
Van Dam, T. J., Letteboer, S. J., Nguyen, T. M. T., Wheway, G., Schmidts, M., Mans, D. A., …Johnson, C. A. (2015). An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes. Nature Cell Biology, 17(8), 1074-1087. https://doi.org/10.1038/ncb3201

© 2015 Macmillan Publishers Limited. Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe a whole-genome siRNA-based reverse genetics screen for defects in biogenesis and/or maintenance of... Read More about An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes.

Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis (2015)
Journal Article
Ouden, K. D., Van Balkom, B. W., Slaats, G. G., Wheway, G., Foletto, V., Szymanska, K., …Giles, R. H. (2015). Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis. Journal of Cell Science, 128(24), 4550-4559. https://doi.org/10.1242/jcs.176065

©2015. To investigate the contribution of ion channels to ciliogenesis, we carried out a small interfering RNA (siRNA)-based reverse genetics screen of all ion channels in the mouse genome in murine inner medullary collecting duct kidney cells. This... Read More about Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis.