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Trans-Atlantic partnership working in developing a UK physician associate programme: Reflections and lessons learnt (2017)
Presentation / Conference
Lawrence, F., Hobbs, R., Stevens, A., & St. John-Matthews, J. (2017, September). Trans-Atlantic partnership working in developing a UK physician associate programme: Reflections and lessons learnt. Poster presented at HEA Networking in Healthcare Education

The Physician Associate profession is an emergent role in the modern UK healthcare system. There are currently 350 PAs working in the UK in a variety of medical fields across the primary and secondary care sectors. However the profession is set to... Read More about Trans-Atlantic partnership working in developing a UK physician associate programme: Reflections and lessons learnt.

Developing guidance for the appropriate use of Computed Tomography within a hybrid imaging environment (2014)
Journal Article
Griffiths, M., Bailey, D., Matthews, F., & Dawson, G. (2014). Developing guidance for the appropriate use of Computed Tomography within a hybrid imaging environment. Imaging and Therapy Practice, June(2014), 5-10

The introduction of Computed Tomography (CT) within the nuclear medicine environment over the last decade has led to a dramatic increase in the number of hybrid imaging installations within the United Kingdom. Modern multislice Single Photon Emissi... Read More about Developing guidance for the appropriate use of Computed Tomography within a hybrid imaging environment.

A role for transportin in the nuclear import of adenovirus core proteins and DNA (2007)
Journal Article
Lawrence, F. J., Hindley, C. E., Lawrence, F., & Matthews, D. A. (2007). A role for transportin in the nuclear import of adenovirus core proteins and DNA. Traffic, 8(10), 1313-1322. https://doi.org/10.1111/j.1600-0854.2007.00618.x

Adenoviruses target their double-stranded DNA genome and its associated core proteins to the interphase nucleus; this core structure then enters through the nuclear pore complex. We have used digitonin permeabilized cell import assays to study the ce... Read More about A role for transportin in the nuclear import of adenovirus core proteins and DNA.

Changes in the balance of the tissue inhibitor of matrix metalloproteinases (TIMPs)-1 and -3 may promote keratocyte apoptosis in keratoconus (2007)
Journal Article
Matthews, F. J., Matthews, F., Cook, S. D., Majid, M. A., Dick, A. D., & Smith, V. A. (2007). Changes in the balance of the tissue inhibitor of matrix metalloproteinases (TIMPs)-1 and -3 may promote keratocyte apoptosis in keratoconus. Experimental Eye Research, 84(6), 1125-1134. https://doi.org/10.1016/j.exer.2007.02.013

Keratoconus is a disease in which the central cornea becomes thinned. This could result from corneal stromal cell apoptosis or be induced or perpetuated by the activation of matrix degrading enzymes, particularly members of the matrix metalloproteina... Read More about Changes in the balance of the tissue inhibitor of matrix metalloproteinases (TIMPs)-1 and -3 may promote keratocyte apoptosis in keratoconus.

Tissue inhibitor of metalloproteinase-3 differentially binds to components of Bruch's membrane (2006)
Journal Article
Dick, A. D., Matthews, F. J., Smith, V. A., Majid, M. A., Majid, M. A., Smith, V. A., …Dick, A. D. (2006). Tissue inhibitor of metalloproteinase-3 differentially binds to components of Bruch's membrane. British Journal of Ophthalmology, 90(10), 1310-1315. https://doi.org/10.1136/bjo.2006.097246

Background: Sorsby's fundus dystrophy (SFD) is caused by mutations in tissue inhibitor of metalloproteinase (TIMP)-3 and, with the exception of early onset, is similar to age-related macular degeneration. The pathological features of this condition r... Read More about Tissue inhibitor of metalloproteinase-3 differentially binds to components of Bruch's membrane.

Nucleolar protein upstream binding factor is sequestered into adenovirus DNA replication centres during infection without affecting RNA polymerase I location or ablating rRNA synthesis (2006)
Journal Article
Lawrence, F., McStay, B., & Matthews, D. A. (2006). Nucleolar protein upstream binding factor is sequestered into adenovirus DNA replication centres during infection without affecting RNA polymerase I location or ablating rRNA synthesis. Journal of Cell Science, 119(12), 2621-2631. https://doi.org/10.1242/%E2%80%8Bjcs.02982

When human adenovirus infects human cells there is disruption of rRNA biogenesis. This report examines the effect of adenovirus infection on the nucleolar protein, upstream binding factor (UBF) which plays a major role in regulating rRNA synthesis. W... Read More about Nucleolar protein upstream binding factor is sequestered into adenovirus DNA replication centres during infection without affecting RNA polymerase I location or ablating rRNA synthesis.

Keratoconus: Matrix metalloproteinase-2 activation and TIMP modulation (2006)
Journal Article
Majid, M. A., Matthews, F. J., Smith, V. A., Smith, V. A., Matthews, F., Majid, M. A., & Cook, S. D. (2006). Keratoconus: Matrix metalloproteinase-2 activation and TIMP modulation. BBA - Molecular Basis of Disease, 1762(4), 431-439. https://doi.org/10.1016/j.bbadis.2006.01.010

Keratoconus is an ocular condition that causes corneal thinning, cone formation and scarring. In view of a hypothesis that activated MMP-2 may initiate or facilitate disease progression, the MMP-2/TIMP systems of stromal cells derived from normal and... Read More about Keratoconus: Matrix metalloproteinase-2 activation and TIMP modulation.

Precursor of human adenovirus core polypeptide Mu targets the nucleolus and modulates the expression of E2 proteins (2004)
Journal Article
Lawrence, F. J., Matthews, D. A., Lee, T. W. R., Lawrence, F., Dauksaite, V., Akusjärvi, G., …Matthews, D. A. (2004). Precursor of human adenovirus core polypeptide Mu targets the nucleolus and modulates the expression of E2 proteins. Journal of General Virology, 85(1), 185-196. https://doi.org/10.1099/vir.0.19352-0

We have examined the subcellular localization properties of human adenovirus 2 (HAdV-2) preMu and mature Mu (pX) proteins as fusions with enhanced green fluorescence protein (EGFP). We determined that preMu is exclusively a nucleolar protein with a s... Read More about Precursor of human adenovirus core polypeptide Mu targets the nucleolus and modulates the expression of E2 proteins.

Ultrastructural localization of sulfated and unsulfated keratan sulfate in normal and macular corneal dystrophy type I (2000)
Journal Article
Lewis, D., Davies, Y., Nieduszynski, I. A., Lawrence, F., Quantock, A. J., Bonshek, R., & Fullwood, N. J. (2000). Ultrastructural localization of sulfated and unsulfated keratan sulfate in normal and macular corneal dystrophy type I. Glycobiology, 10(3), 305-312. https://doi.org/10.1093/glycob/10.3.305

Keratan sulfate (KS) proteoglycans are of importance for the maintenance of corneal transparency as evidenced in the condition macular corneal dystrophy type I (MCD I), a disorder involving the absence of KS sulfation, in which the cornea becomes opa... Read More about Ultrastructural localization of sulfated and unsulfated keratan sulfate in normal and macular corneal dystrophy type I.