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BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer (2020)
Journal Article
Ahmed Shafei, M., Forshaw, T., Davis, J., Flemban, A., Qualtrough, D., Dean, S., …Conway, M. E. (2020). BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer. Oncotarget, 11, 1971-1987. https://doi.org/10.18632/oncotarget.27607

The cytosolic branched chain aminotransferase (BCATc) protein has been found to be highly expressed in breast cancer subtypes, including triple negative breast cancer (TNBC), compared with normal breast tissue. The catabolism of branched-chain amino... Read More about BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer.

Hypoxia modulates the stem cell population and induces EMT in the MCF-10A breast epithelial cell line (2017)
Journal Article
Daly, C. S., Dean, S. J., Daly, C., Conway, M. E., Qualtrough, D., Shafei, M., & Flemban, A. (2018). Hypoxia modulates the stem cell population and induces EMT in the MCF-10A breast epithelial cell line. Oncology Reports, 39(2), 483-490. https://doi.org/10.3892/or.2017.6125

A common feature among pre-malignant lesions is the induction of hypoxia through increased cell propagation and reduced access to blood flow. Hypoxia in breast cancer has been associated with poor patient prognosis, resistance to chemotherapy and inc... Read More about Hypoxia modulates the stem cell population and induces EMT in the MCF-10A breast epithelial cell line.

The hedgehog inhibitor cyclopamine reduces β-catenin-Tcf transcriptional activity, induces E-cadherin expression, and reduces invasion in colorectal cancer cells (2015)
Journal Article
Qualtrough, D., Rees, P., Speight, B., Williams, A. C., & Paraskeva, C. (2015). The hedgehog inhibitor cyclopamine reduces β-catenin-Tcf transcriptional activity, induces E-cadherin expression, and reduces invasion in colorectal cancer cells. Cancers, 7(3), 1885-1899. https://doi.org/10.3390/cancers7030867

© 2015 by the authors; licensee MDPI, Basel, Switzerland. Colorectal cancer is a major global health problem resulting in over 600,000 deaths world-wide every year with the majority of these due to metastatic disease. Wnt signalling, and more specifi... Read More about The hedgehog inhibitor cyclopamine reduces β-catenin-Tcf transcriptional activity, induces E-cadherin expression, and reduces invasion in colorectal cancer cells.

The potential role of hedgehog signaling in the luminal/basal phenotype of breast epithelia and in breast cancer invasion and metastasis (2015)
Journal Article
Qualtrough, D., & Flemban, A. (2015). The potential role of hedgehog signaling in the luminal/basal phenotype of breast epithelia and in breast cancer invasion and metastasis. Cancers, 7(3), 1863-1884. https://doi.org/10.3390/cancers7030866

© 2015 by the authors; licensee MDPI, Basel, Switzerland. The epithelium of the lactiferous ducts in the breast is comprised of luminal epithelial cells and underlying basal myoepithelial cells. The regulation of cell fate and transit of cells betwee... Read More about The potential role of hedgehog signaling in the luminal/basal phenotype of breast epithelia and in breast cancer invasion and metastasis.

The actin-bundling protein Fascin is overexpressed in inflammatory bowel disease and may be important in tissue repair (2011)
Journal Article
Qualtrough, D., Smallwood, K., Littlejohns, D., & Pignatelli, M. (2011). The actin-bundling protein Fascin is overexpressed in inflammatory bowel disease and may be important in tissue repair. BMC Gastroenterology, 11(14), https://doi.org/10.1186/1471-230X-11-14

Background: Fascin is associated with increased cell motility in colorectal tumours but is absent from the normal colonic epithelium. We examined the expression of fascin in inflammatory bowel disease (IBD) and its location at regions undergoing rest... Read More about The actin-bundling protein Fascin is overexpressed in inflammatory bowel disease and may be important in tissue repair.

The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro (2009)
Journal Article
Qualtrough, D., Singh, K., Banu, N., Paraskeva, C., & Pignatelli, M. (2009). The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro. British Journal of Cancer, 101(7), 1124-1129. https://doi.org/10.1038/sj.bjc.6605286

Background: Fascin is overexpressed in many cancers, including colorectal, but its role in the malignant transformation of benign colorectal adenomas is unclear. Methods: Immunohistochemical analysis of fascin expression was carried out in resected h... Read More about The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro.


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