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Overload for ionized solutes in reversed-phase high-performance liquid chromatography (2006)
Journal Article
McCalley, D. V. (2006). Overload for ionized solutes in reversed-phase high-performance liquid chromatography. Analytical Chemistry, 78(8), 2532-2538. https://doi.org/10.1021/ac052098b

Overloading occurs for submicrogram quantities of ionized solutes particularly when using low ionic strength mobile phases at low pH (e.g., formic acid), even with highly inert silica RP-HPLC columns of normal dimensions. Much higher loads can produc... Read More about Overload for ionized solutes in reversed-phase high-performance liquid chromatography.