All Outputs (4)

Understanding and manipulating the separation in hydrophilic interaction liquid chromatography (2017)
Journal Article
McCalley, D. V. (2017). Understanding and manipulating the separation in hydrophilic interaction liquid chromatography. Journal of Chromatography A, 1523, 49-71. https://doi.org/10.1016/j.chroma.2017.06.026

© 2017 Elsevier B.V. Hydrophilic interaction liquid chromatography (HILIC) has emerged as a valuable complimentary technique to reversed-phase (RP), being especially suited for the analysis of polar and ionised solutes, which are difficult to retain... Read More about Understanding and manipulating the separation in hydrophilic interaction liquid chromatography.

Core-Shell, Ultrasmall Particles, Monoliths, and Other Support Materials in High-Performance Liquid Chromatography (2016)
Journal Article
Tanaka, N., & McCalley, D. V. (2016). Core-Shell, Ultrasmall Particles, Monoliths, and Other Support Materials in High-Performance Liquid Chromatography. Analytical Chemistry, 88(1), 279-298. https://doi.org/10.1021/acs.analchem.5b04093

A review of the developments that have taken place in the area of supports for high performance liquid chromatography in recent years.

The impact of pressure and frictional heating on retention, selectivity and efficiency in ultra-high-pressure liquid chromatography (2014)
Journal Article
McCalley, D. V. (2014). The impact of pressure and frictional heating on retention, selectivity and efficiency in ultra-high-pressure liquid chromatography. Trends in Analytical Chemistry, 63, 31-43. https://doi.org/10.1016/j.trac.2014.06.024

© 2014 Elsevier B.V. The effects of pressure and frictional heating deserve serious consideration in ultra-high-pressure liquid chromatography (UHPLC) separations, as the pressures used can be three times greater than those in conventional high-perfo... Read More about The impact of pressure and frictional heating on retention, selectivity and efficiency in ultra-high-pressure liquid chromatography.

The challenges of the analysis of basic compounds by high performance liquid chromatography: Some possible approaches for improved separations (2010)
Journal Article
McCalley, D. V. (2010). The challenges of the analysis of basic compounds by high performance liquid chromatography: Some possible approaches for improved separations. Journal of Chromatography A, 1217(6), 858-880. https://doi.org/10.1016/j.chroma.2009.11.068

This review considers some of the difficulties encountered with the analysis of ionised bases using reversed-phase chromatography, such as detrimental interaction with column silanol groups, and overloading which both lead to poor peak shapes. Method... Read More about The challenges of the analysis of basic compounds by high performance liquid chromatography: Some possible approaches for improved separations.