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Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films (2019)
Patent
Cox, T., Kiely, J., Ratcliffe, N., deLacy Costello, B., & Luxton, R. (2019). Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films

The invention relates to the field of sensors for detecting volatile compounds. The sensor of the present invention for detecting volatile compounds comprises: a film of metal oxide; a heater configured to provide heat energy to the film of metal oxi... Read More about Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films.

Sniffing out resistance – Rapid identification of urinary tract infection-causing bacteria and their antibiotic susceptibility using volatile metabolite profiles (2019)
Journal Article
Smart, A., de Lacy Costello, B., White, P., Avison, M., Batty, C., Turner, C., …Ratcliffe, N. (2019). Sniffing out resistance – Rapid identification of urinary tract infection-causing bacteria and their antibiotic susceptibility using volatile metabolite profiles. Journal of Pharmaceutical and Biomedical Analysis, 167, 59-65. https://doi.org/10.1016/j.jpba.2019.01.044

© 2019 Elsevier B.V. Antibiotic resistance is set to be an unprecedented threat to modern medicine. ‘Sniffing’ bacteria potentially offers a rapid way to determine susceptibility. A successful proof-of-principle study is described, using thermal deso... Read More about Sniffing out resistance – Rapid identification of urinary tract infection-causing bacteria and their antibiotic susceptibility using volatile metabolite profiles.

Gas chromatography mass spectrometry (GC-MS) quantification of metabolites in stool using13 C labelled compounds (2018)
Journal Article
Gould, O., Costello, B. D. L., Smart, A., Jones, P., Macmaster, A., Ransley, K., & Ratcliffe, N. (2018). Gas chromatography mass spectrometry (GC-MS) quantification of metabolites in stool using13 C labelled compounds. Metabolites, 8(4), 75. https://doi.org/10.3390/metabo8040075

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. It has become increasingly important to qualitatively and quantitatively assess the volatile metabolites in a range of bodily fluids for use in monitoring health. There has been relatively lit... Read More about Gas chromatography mass spectrometry (GC-MS) quantification of metabolites in stool using13 C labelled compounds.

Assessment of a combined gas chromatography mass spectrometer sensor system for detecting biologically relevant volatile compounds (2017)
Journal Article
Gould, O., Ratcliffe, N. M., De Lacy Costello, B., Wieczorek, T., & Persad, R. (2018). Assessment of a combined gas chromatography mass spectrometer sensor system for detecting biologically relevant volatile compounds. Journal of Breath Research, 12(1), 016009. https://doi.org/10.1088/1752-7163/aa8efe

© 2017 IOP Publishing Ltd. There have been a number of studies in which metal oxide sensors (MOS) have replaced conventional analytical detectors in gas chromatography systems. However, despite the use of these instruments in a range of applications... Read More about Assessment of a combined gas chromatography mass spectrometer sensor system for detecting biologically relevant volatile compounds.

Irritable bowel syndrome and active inflammatory bowel disease diagnosed by faecal gas analysis (2016)
Journal Article
de Lacy Costello, B., White, P., Aggio, R. B., White, P., Jayasena, H., de Lacy Costello, B., …Probert, C. S. (2017). Irritable bowel syndrome and active inflammatory bowel disease diagnosed by faecal gas analysis. Alimentary Pharmacology and Therapeutics, 45(1), 82-90. https://doi.org/10.1111/apt.13822

© 2016 John Wiley & Sons Ltd Background: Inflammatory bowel disease and irritable bowel syndrome may present in a similar manner. Measuring faecal calprotectin concentration is often recommended to rule out inflammatory bowel disease, however, ther... Read More about Irritable bowel syndrome and active inflammatory bowel disease diagnosed by faecal gas analysis.

A review of the volatiles from the healthy human body (2014)
Journal Article
Ratcliffe, N. M., Al-Kateb, H., De Lacy Costello, B., de Lacy Costello, B., Amann, A., Al-Kateb, H., …Ratcliffe, N. M. (2014). A review of the volatiles from the healthy human body. Journal of Breath Research, 8(1), https://doi.org/10.1088/1752-7155/8/1/014001

A compendium of all the volatile organic compounds (VOCs) emanating from the human body (the volatolome) is for the first time reported. 1840 VOCs have been assigned from breath (872), saliva (359), blood (154), milk (256), skin secretions (532) urin... Read More about A review of the volatiles from the healthy human body.

The use of a gas chromatograph coupled to a metal oxide sensor for rapid assessment of stool samples from irritable bowel syndrome and inflammatory bowel disease patients (2014)
Journal Article
Ratcliffe, N. M., Probert, C. S., Vaughan, K., De Lacy Costello, B. P., McGuire, N. D., Shepherd, S. F., …Ratcliffe, N. M. (2014). The use of a gas chromatograph coupled to a metal oxide sensor for rapid assessment of stool samples from irritable bowel syndrome and inflammatory bowel disease patients. Journal of Breath Research, 8(2), https://doi.org/10.1088/1752-7155/8/2/026001

There is much clinical interest in the development of a low-cost and reliable test for diagnosing inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), two very distinct diseases that can present with similar symptoms. The assessment o... Read More about The use of a gas chromatograph coupled to a metal oxide sensor for rapid assessment of stool samples from irritable bowel syndrome and inflammatory bowel disease patients.

Towards point of care testing for C. difficile infection by volatile profiling, using the combination of a short multi-capillary gas chromatography column with metal oxide sensor detection (2014)
Journal Article
Ratcliffe, N. M., Vaughan, K., Probert, C. S., Garner, C. E., De Lacy Costello, B., McGuire, N. D., …Ratcliffe, N. M. (2014). Towards point of care testing for C. difficile infection by volatile profiling, using the combination of a short multi-capillary gas chromatography column with metal oxide sensor detection. Measurement Science and Technology, 25(6), https://doi.org/10.1088/0957-0233/25/6/065108

Rapid volatile profiling of stool sample headspace was achieved using a combination of short multi-capillary chromatography column (SMCC), highly sensitive heated metal oxide semiconductor sensor and artificial neural network software. For direct ana... Read More about Towards point of care testing for C. difficile infection by volatile profiling, using the combination of a short multi-capillary gas chromatography column with metal oxide sensor detection.

An investigation of volatile organic compounds from the saliva of healthy individuals using headspace-trap/GC-MS (2013)
Journal Article
Ratcliffe, N., De Lacy Costello, B., Al-Kateb, H., de Lacy Costello, B., & Ratcliffe, N. M. (2013). An investigation of volatile organic compounds from the saliva of healthy individuals using headspace-trap/GC-MS. Journal of Breath Research, 7(3), https://doi.org/10.1088/1752-7155/7/3/036004

Analysis of volatile organic compounds (VOCs) from saliva, to aid disease diagnoses, has received little attention. This work aims to address the paucity of information on saliva volatiles and includes a database of newly identified compounds whilst... Read More about An investigation of volatile organic compounds from the saliva of healthy individuals using headspace-trap/GC-MS.

Analysis of the volatiles in the headspace above the plasmodium and sporangia of the slime mould (Physarum polycephalum) by SPME-GCMS (2013)
Journal Article
AL-Kateb, H., & Costello, B. D. L. (2013). Analysis of the volatiles in the headspace above the plasmodium and sporangia of the slime mould (Physarum polycephalum) by SPME-GCMS

Solid phase micro-extraction (SPME) coupled with Gas Chromatography Mass Spectrometry (GC-MS) was used to extract and analyse the volatiles in the headspace above the plasmodial and sporulating stages of the slime mould Physarum Polycephalum. In tota... Read More about Analysis of the volatiles in the headspace above the plasmodium and sporangia of the slime mould (Physarum polycephalum) by SPME-GCMS.

A Pilot Study Combining a GC-Sensor Device with a Statistical Model for the Identification of Bladder Cancer from Urine Headspace (2013)
Journal Article
Ratcliffe, N., Probert, C. S., Ewen, R., Khalid, T., White, P., De Lacy Costello, B., …Ratcliffe, N. M. (2013). A Pilot Study Combining a GC-Sensor Device with a Statistical Model for the Identification of Bladder Cancer from Urine Headspace. PLoS ONE, 8(7), https://doi.org/10.1371/journal.pone.0069602

There is a need to reduce the number of cystoscopies on patients with haematuria. Presently there are no reliable biomarkers to screen for bladder cancer. In this paper, we evaluate a new simple in-house fabricated, GC-sensor device in the diagnosis... Read More about A Pilot Study Combining a GC-Sensor Device with a Statistical Model for the Identification of Bladder Cancer from Urine Headspace.

Observation, characterization and modeling of memristor current spikes (2013)
Journal Article
Gale, E., de Lacy Costello, B., & Adamatzky, A. (2013). Observation, characterization and modeling of memristor current spikes. https://doi.org/10.12785/amis/070418

Memristors have been compared to neurons (usually specifically the synapses) since 1976 but no experimental evidence has been offered for support for this position. Here we highlight that memristors naturally form fast-response, highly reproducible a... Read More about Observation, characterization and modeling of memristor current spikes.

The importance of methane breath testing: A review (2013)
Journal Article
Ratcliffe, N. M., De Lacy Costello, B. P., de Lacy Costello, B., Ledochowski, M., & Ratcliffe, N. M. (2013). The importance of methane breath testing: A review. Journal of Breath Research, 7(2), https://doi.org/10.1088/1752-7155/7/2/024001

Sugar malabsorption in the bowel can lead to bloating, cramps, diarrhea and other symptoms of irritable bowel syndrome as well as affecting absorption of other nutrients. The hydrogen breath test is now a well established noninvasive test for assessi... Read More about The importance of methane breath testing: A review.

The use of MS for the investigation of irritable bowel syndrome and inflammatory bowel disease (2013)
Journal Article
Ratcliffe, N. M., de Lacy Costello, B., & Shepherd, S. (2013). The use of MS for the investigation of irritable bowel syndrome and inflammatory bowel disease. Clinical laboratory international, 37, 18-20

Currently, the diagnosis of bowel diseases such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) relies on invasive and expensive procedures. Identification of biomarker-based tests to aid diagnosis is an important area of resea... Read More about The use of MS for the investigation of irritable bowel syndrome and inflammatory bowel disease.

Volatile organic compounds (VOCs) found in urine and stool (2013)
Book Chapter
de Lacy Costello, B., & Ratcliffe, N. M. (2013). Volatile organic compounds (VOCs) found in urine and stool. In A. Amann, & D. Smith (Eds.), Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine, 405-462. Elsevier

Beyond Markov chains, towards adaptive memristor network-based music generation (2013)
Presentation / Conference
Gale, E., Matthews, O., de Lacy Costello, B., & Adamatzky, A. (2013, April). Beyond Markov chains, towards adaptive memristor network-based music generation. Paper presented at First AISB symposium on Music and Unconventional Computing

We undertook a study of the use of a memristor network for music generation, making use of the memristor's memory to go beyond the Markov hypothesis. Seed transition matrices are created and populated using memristor equations, and which are shown to... Read More about Beyond Markov chains, towards adaptive memristor network-based music generation.

An Investigation of Fecal Volatile Organic Metabolites in Irritable Bowel Syndrome (2013)
Journal Article
Probert, C. S., de Costello, B. L., Ahmed, I., Greenwood, R., de Lacy Costello, B., Ratcliffe, N. M., & Probert, C. (2013). An Investigation of Fecal Volatile Organic Metabolites in Irritable Bowel Syndrome. PLoS ONE, 8(3), https://doi.org/10.1371/journal.pone.0058204

Diagnosing irritable bowel syndrome (IBS) can be a challenge; many clinicians resort to invasive investigations in order to rule out other diseases and reassure their patients. Volatile organic metabolites (VOMs) are emitted from feces; understanding... Read More about An Investigation of Fecal Volatile Organic Metabolites in Irritable Bowel Syndrome.

Volatiles from oral anaerobes confounding breath biomarker discovery (2013)
Journal Article
De Lacy Costello, B., Khalid, T. Y., Ratcliffe, N. M., Khalid, T., Saad, S., Greenman, J., …Ratcliffe, N. M. (2013). Volatiles from oral anaerobes confounding breath biomarker discovery. Journal of Breath Research, 7(1), https://doi.org/10.1088/1752-7155/7/1/017114

The levels of compounds in exhaled mouth air do not necessarily reflect levels in the systemic circulation as bacteria can bio-transform substrates to produce compounds within the mouth. This should be of concern to researchers measuring breath volat... Read More about Volatiles from oral anaerobes confounding breath biomarker discovery.

A diagnostic apparatus for analysing a sample to diagnose disease (2012)
Patent
Ratcliffe, N. M., de Lacy Costello, B., Ewen, R., & Probert, C. (2012). A diagnostic apparatus for analysing a sample to diagnose disease. EP2502065 A2 (text from WO2011061308A2)

A diagnostic apparatus (10) for analysing a sample to diagnose disease, the apparatus (10) comprising: a separating element (16) for separating gas derived from the sample into component parts; a sensor arrangement (18) coupled to the separating elem... Read More about A diagnostic apparatus for analysing a sample to diagnose disease.

Logical and arithmetic circuits in Belousov-Zhabotinsky encapsulated disks (2011)
Journal Article
Holley, J., Jahan, I., De Lacy Costello, B., Bull, L., & Adamatzky, A. (2011). Logical and arithmetic circuits in Belousov-Zhabotinsky encapsulated disks. Physical Review E, 84(5), 056110. https://doi.org/10.1103/PhysRevE.84.056110

Excitation waves on a subexcitable Belousov-Zhabotinsky (BZ) substrate can be manipulated by chemical variations in the substrate and by interactions with other waves. Symbolic assignment and interpretation of wave dynamics can be used to perform log... Read More about Logical and arithmetic circuits in Belousov-Zhabotinsky encapsulated disks.