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ICI-RS 2019 nocturia think tank: How can experimental science guide us in understanding the pathophysiology of nocturia? (2020)
Journal Article
Vahabi, B., Jabr, R., Fry, C., McCloskey, K., Everaert, K., Agudelo, C. W., …Weiss, J. P. (in press). ICI-RS 2019 nocturia think tank: How can experimental science guide us in understanding the pathophysiology of nocturia?. Neurourology and Urodynamics, https://doi.org/10.1002/nau.24274

© 2020 Wiley Periodicals, Inc. Introduction: The following is a report on the proceedings of the 2019 International Consultation on Incontinence-Research Society nocturia think tank (NTT). Objectives: The objectives of the 2019 NTT were as follows: (... Read More about ICI-RS 2019 nocturia think tank: How can experimental science guide us in understanding the pathophysiology of nocturia?.

Influence of sildenafil on the purinergic components of nerve-mediated and urothelial ATP release from the bladder of normal and spinal cord injured mice (2019)
Journal Article
Chakrabarty, B., Ito, H., Ximenes, M., Nishikawa, N., Vahabi, B., Kanai, A. J., …Fry, C. H. (2019). Influence of sildenafil on the purinergic components of nerve-mediated and urothelial ATP release from the bladder of normal and spinal cord injured mice. British Journal of Pharmacology, 176(13), 2227-2237. https://doi.org/10.1111/bph.14669

© 2019 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. Background and purpose: PDE inhibitors such as sildenafil alleviate lower urinary tract symptoms; however, a comple... Read More about Influence of sildenafil on the purinergic components of nerve-mediated and urothelial ATP release from the bladder of normal and spinal cord injured mice.

Modulation of bladder wall micromotions alters intravesical pressure activity in the isolated bladder (2019)
Journal Article
Chakrabarty, B., Bijos, D. A., Vahabi, B., Clavica, F., Kanai, A. J., Pickering, A. E., …Drake, M. J. (2019). Modulation of bladder wall micromotions alters intravesical pressure activity in the isolated bladder. Frontiers in Physiology, 9, https://doi.org/10.3389/fphys.2018.01937

Micromotions are phasic contractions of the bladder wall. During urine storage, such phasic activity has little effect on intravesical pressure, however, changed motile activity may underlie urodynamic observations such as detrusor overactivity. The... Read More about Modulation of bladder wall micromotions alters intravesical pressure activity in the isolated bladder.

The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties (2018)
Journal Article
Jumbe, S., Porazinski, S., Oltean, S., Mansell, J., Vahabi, B., Wilson, I., & Ladomery, M. (2019). The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties. Translational Oncology, 12(1), 134-142. https://doi.org/10.1016/j.tranon.2018.09.001

© 2018 The oncogene ERG encodes an ETS family transcription factor and is implicated in blood, vascular, and bone development and in prostate, blood, and bone cancer. The ERG gene is alternatively spliced; of particular interest is its cassette exon... Read More about The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties.

Mild external heating and reduction in spontaneous contractions of the bladder (2017)
Journal Article
Kitney, D. G., Kitney, D., Jabr, R., Vahabi, B., & Fry, C. (2017). Mild external heating and reduction in spontaneous contractions of the bladder. BJU International, 120(5), 724-730. https://doi.org/10.1111/bju.13933

© 2017 The Authors BJU International © 2017 BJU International Published by John Wiley & Sons Ltd Objectives: To measure the effect of external heating on bladder wall contractile function, histological structure and expression of proteins related t... Read More about Mild external heating and reduction in spontaneous contractions of the bladder.

Cell biology (2017)
Book Chapter
Fry, C., Chess-Williams, R., Hashitani, H., Kanai, A., McCloskey, K., Takeda, M., & Vahabi, B. (2017). Cell biology. In P. Abrams, L. Cardozo, A. Wagg, & A. Wein (Eds.), Incontinence, 143. ICS

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Is electrolyte transfer across the urothelium important?: ICI-RS 2015 (2017)
Journal Article
McCluskey, K., Vahabi, B., & Fry, C. (2017). Is electrolyte transfer across the urothelium important?: ICI-RS 2015

Abstract AIMS: This article summarizes discussion at the International Consultation on Incontinence Research Society (ICI-RS) 2015 meeting of urine modification in the urinary tract by the urothelium. It considers the literature and proposes pertin... Read More about Is electrolyte transfer across the urothelium important?: ICI-RS 2015.

Can we define and characterize the aging lower urinary tract?-ICI-RS 2015 (2017)
Journal Article
Vahabi, B., Wagg, A. S., Rosier, P. F. W. M., Rademakers, K. L. J., Denys, M., Pontari, M., …Fry, C. H. (2017). Can we define and characterize the aging lower urinary tract?-ICI-RS 2015. Neurourology and Urodynamics, 36(4), 854-858. https://doi.org/10.1002/nau.23035

The prevalence of lower urinary tract (LUT) symptoms increases with age but the etiology is unknown. This article aims to identify research directions that clarify the basis of this association. The initial question is whether biological age is the v... Read More about Can we define and characterize the aging lower urinary tract?-ICI-RS 2015.

Can we define and characterize the aging lower urinary tract?—ICI-RS 2015 (2017)
Journal Article
Fry, C. H., Nelson, P. P., Valentini, F. A., Rademakers, K. L., Rosier, P. F., Wagg, A. S., …Fry, C. H. (2017). Can we define and characterize the aging lower urinary tract?—ICI-RS 2015. Neurourology and Urodynamics, 36(4), 854-858. https://doi.org/10.1002/nau.23035

© 2017 Wiley Periodicals, Inc. The prevalence of lower urinary tract (LUT) symptoms increases with age but the etiology is unknown. This article aims to identify research directions that clarify the basis of this association. The initial question is... Read More about Can we define and characterize the aging lower urinary tract?—ICI-RS 2015.

Estimation of bladder contractility from intravesical pressure–volume measurements (2016)
Journal Article
Kitney, D. G., Drake, M. J., Fry, C. H., Fry, C. H., Gammie, A., Drake, M., …Vahabi, B. (2017). Estimation of bladder contractility from intravesical pressure–volume measurements. Neurourology and Urodynamics, 36(4), 1009-1014. https://doi.org/10.1002/nau.23047

© 2016 Wiley Periodicals, Inc. Aims: To describe parameters from urodynamic pressure recordings that describe urinary bladder contractility through the use of principles of muscle mechanics. Methods: Subtracted detrusor pressure and voided flow were... Read More about Estimation of bladder contractility from intravesical pressure–volume measurements.

The Role of the Mucosa in Normal and Abnormal Bladder Function (2016)
Journal Article
Fry, C. H., Fry, C., & Vahabi, B. (2016). The Role of the Mucosa in Normal and Abnormal Bladder Function. Basic and Clinical Pharmacology and Toxicology, 119(53), 57-62. https://doi.org/10.1111/bcpt.12626

© 2016 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society) The internal face of the detrusor smooth muscle wall of the urinary bladder is covered by a mucosa, separating muscle from the hostile environment of urine.... Read More about The Role of the Mucosa in Normal and Abnormal Bladder Function.

Physiological and pathophysiological implications of micromotion activity in urinary bladder function (2015)
Journal Article
Drake, M. J., Vahabi, B., Vahabi, B., & Drake, M. J. (2015). Physiological and pathophysiological implications of micromotion activity in urinary bladder function. Acta Physiologica, 213(2), 360-370. https://doi.org/10.1111/apha.12373

© 2014 Scandinavian Physiological Society. 'Micromotions' is a term signifying the presence of localized microcontractions and microelongations, alongside non-motile areas. The motile areas tend to shift over the bladder surface with time, and the in... Read More about Physiological and pathophysiological implications of micromotion activity in urinary bladder function.

Anoctamin-1 in the juvenile rat urinary bladder (2014)
Journal Article
Bijos, D. A., Bijos, D., Drake, M. J., & Vahabi, B. (2014). Anoctamin-1 in the juvenile rat urinary bladder. PLoS ONE, 9(9), https://doi.org/10.1371/journal.pone.0106190

Purpose: To investigate presence, location and functional role of calcium-activated chloride channel (CaCC) Anoctamin-1 (Ano1) in rat urinary bladder. Materials and Methods: Bladders from 3 week old Wistar rats were studied. End-point PCR on total mR... Read More about Anoctamin-1 in the juvenile rat urinary bladder.

Trpm8 agonists modulate contraction of the pig urinary bladder (2013)
Journal Article
Parsons, B. A., Drake, M. J., Vahabi, B., Parsons, B. A., Doran, O., Rhodes, A., …Drake, M. (2013). Trpm8 agonists modulate contraction of the pig urinary bladder. Canadian Journal of Physiology and Pharmacology, 91(7), 503-509. https://doi.org/10.1139/cjpp-2012-0406

The transient receptor potential melastin-8 (TRPM8) channel is activated by the "cooling" compounds menthol and icilin. Pathophysiologically, it is implicated in the overactive bladder and bladder cooling reflex, but the activity of TRPM8 in normal b... Read More about Trpm8 agonists modulate contraction of the pig urinary bladder.