Skip to main content

Research Repository

Advanced Search

All Outputs (18)

Influence of sildenafil on the purinergic components of nerve-mediated and urothelial ATP release from the bladder of normal and spinal cord injured mice (2019)
Journal Article
Chakrabarty, B., Ito, H., Ximenes, M., Nishikawa, N., Vahabi, B., Kanai, A. J., …Fry, C. H. (2019). Influence of sildenafil on the purinergic components of nerve-mediated and urothelial ATP release from the bladder of normal and spinal cord injured mice. British Journal of Pharmacology, 176(13), 2227-2237. https://doi.org/10.1111/bph.14669

© 2019 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. Background and purpose: PDE inhibitors such as sildenafil alleviate lower urinary tract symptoms; however, a comple... Read More about Influence of sildenafil on the purinergic components of nerve-mediated and urothelial ATP release from the bladder of normal and spinal cord injured mice.

Modulation of bladder wall micromotions alters intravesical pressure activity in the isolated bladder (2019)
Journal Article
Chakrabarty, B., Bijos, D. A., Vahabi, B., Clavica, F., Kanai, A. J., Pickering, A. E., …Drake, M. J. (2019). Modulation of bladder wall micromotions alters intravesical pressure activity in the isolated bladder. Frontiers in Physiology, 9, Article 1937. https://doi.org/10.3389/fphys.2018.01937

Micromotions are phasic contractions of the bladder wall. During urine storage, such phasic activity has little effect on intravesical pressure, however, changed motile activity may underlie urodynamic observations such as detrusor overactivity. The... Read More about Modulation of bladder wall micromotions alters intravesical pressure activity in the isolated bladder.

The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties (2018)
Journal Article
Jumbe, S., Porazinski, S., Oltean, S., Mansell, J., Vahabi, B., Wilson, I., & Ladomery, M. (2019). The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties. Translational Oncology, 12(1), 134-142. https://doi.org/10.1016/j.tranon.2018.09.001

© 2018 The oncogene ERG encodes an ETS family transcription factor and is implicated in blood, vascular, and bone development and in prostate, blood, and bone cancer. The ERG gene is alternatively spliced; of particular interest is its cassette exon... Read More about The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties.

Mild external heating and reduction in spontaneous contractions of the bladder (2017)
Journal Article
Kitney, D. G., Jabr, R., Vahabi, B., & Fry, C. (2017). Mild external heating and reduction in spontaneous contractions of the bladder. BJU International, 120(5), 724-730. https://doi.org/10.1111/bju.13933

© 2017 The Authors BJU International © 2017 BJU International Published by John Wiley & Sons Ltd Objectives: To measure the effect of external heating on bladder wall contractile function, histological structure and expression of proteins related t... Read More about Mild external heating and reduction in spontaneous contractions of the bladder.

Is electrolyte transfer across the urothelium important?: ICI-RS 2015 (2017)
Journal Article
McCluskey, K., Vahabi, B., & Fry, C. (2017). Is electrolyte transfer across the urothelium important?: ICI-RS 2015

Abstract AIMS: This article summarizes discussion at the International Consultation on Incontinence Research Society (ICI-RS) 2015 meeting of urine modification in the urinary tract by the urothelium. It considers the literature and proposes pertin... Read More about Is electrolyte transfer across the urothelium important?: ICI-RS 2015.

Can we define and characterize the aging lower urinary tract?-ICI-RS 2015 (2017)
Journal Article
Vahabi, B., Wagg, A. S., Rosier, P. F. W. M., Rademakers, K. L. J., Denys, M., Pontari, M., …Fry, C. H. (2017). Can we define and characterize the aging lower urinary tract?-ICI-RS 2015. Neurourology and Urodynamics, 36(4), 854-858. https://doi.org/10.1002/nau.23035

The prevalence of lower urinary tract (LUT) symptoms increases with age but the etiology is unknown. This article aims to identify research directions that clarify the basis of this association. The initial question is whether biological age is the v... Read More about Can we define and characterize the aging lower urinary tract?-ICI-RS 2015.

Estimation of bladder contractility from intravesical pressure–volume measurements (2016)
Journal Article
Fry, C. H., Gammie, A., Drake, M. J., Abrams, P., Kitney, D. G., & Vahabi, B. (2017). Estimation of bladder contractility from intravesical pressure–volume measurements. Neurourology and Urodynamics, 36(4), 1009-1014. https://doi.org/10.1002/nau.23047

© 2016 Wiley Periodicals, Inc. Aims: To describe parameters from urodynamic pressure recordings that describe urinary bladder contractility through the use of principles of muscle mechanics. Methods: Subtracted detrusor pressure and voided flow were... Read More about Estimation of bladder contractility from intravesical pressure–volume measurements.

What is the role for biomarkers for lower urinary tract disorders? ICI-RS 2013 (2014)
Journal Article
Birder, L. A., Fry, C. H., Sahai, A., Vahabi, B., Kanai, A. J., & Birder, L. A. (2014). What is the role for biomarkers for lower urinary tract disorders? ICI-RS 2013. Neurourology and Urodynamics, 33(5), 602-605. https://doi.org/10.1002/nau.22558

Aims A biomarker is an entity that measures a normal or pathological process, or the response to an intervention. A biomarker must measure exclusively and be sufficiently sensitive to the process of interest. Alternatively, a biomarker may give clues... Read More about What is the role for biomarkers for lower urinary tract disorders? ICI-RS 2013.

Anoctamin-1 in the juvenile rat urinary bladder (2014)
Journal Article
Bijos, D. A., Drake, M. J., & Vahabi, B. (2014). Anoctamin-1 in the juvenile rat urinary bladder. PLoS ONE, 9(9), https://doi.org/10.1371/journal.pone.0106190

Purpose: To investigate presence, location and functional role of calcium-activated chloride channel (CaCC) Anoctamin-1 (Ano1) in rat urinary bladder. Materials and Methods: Bladders from 3 week old Wistar rats were studied. End-point PCR on total mR... Read More about Anoctamin-1 in the juvenile rat urinary bladder.

Trpm8 agonists modulate contraction of the pig urinary bladder (2013)
Journal Article
Parsons, B. A., Drake, M. J., Vahabi, B., Parsons, B. A., Doran, O., Rhodes, A., …Drake, M. (2013). Trpm8 agonists modulate contraction of the pig urinary bladder. Canadian Journal of Physiology and Pharmacology, 91(7), 503-509. https://doi.org/10.1139/cjpp-2012-0406

The transient receptor potential melastin-8 (TRPM8) channel is activated by the "cooling" compounds menthol and icilin. Pathophysiologically, it is implicated in the overactive bladder and bladder cooling reflex, but the activity of TRPM8 in normal b... Read More about Trpm8 agonists modulate contraction of the pig urinary bladder.

The validation of a functional, isolated pig bladder model for physiological experimentation (2012)
Journal Article
Fry, C. H., Drake, M. J., Parsons, B. A., Gammie, A., & Vahabi, B. (2012). The validation of a functional, isolated pig bladder model for physiological experimentation. Frontiers in Pharmacology, 3 APR(52), 1-8. https://doi.org/10.3389/fphar.2012.00052

Characterizing the integrative physiology of the bladder requires whole organ preparations. The purpose of this study was to validate an isolated large animal (pig) bladder preparation, through arterial and intravesical drug administration, intravesi... Read More about The validation of a functional, isolated pig bladder model for physiological experimentation.

Phasic activity of urinary bladder smooth muscle in the streptozotocin-induced diabetic rat: Effect of potassium channel modulators (2011)
Journal Article
Sellers, D. J., McKay, N. G., Vahabi, B., & Lawson, K. (2011). Phasic activity of urinary bladder smooth muscle in the streptozotocin-induced diabetic rat: Effect of potassium channel modulators. European Journal of Pharmacology, 660(2-3), 431-437. https://doi.org/10.1016/j.ejphar.2011.03.053

Increased phasic activity in the bladder smooth muscle of animal models and patients with detrusor overactivity has been suggested to underlie the pathophysiology of overactive bladder. Potassium (K+) channels are key regulators of bladder smooth mus... Read More about Phasic activity of urinary bladder smooth muscle in the streptozotocin-induced diabetic rat: Effect of potassium channel modulators.

The role of c-kit-positive interstitial cells in mediating phasic contractions of bladder strips from streptozotocin-induced diabetic rats (2011)
Journal Article
Sellers, D. J., McKay, N. G., Vahabi, B., & Lawson, K. (2011). The role of c-kit-positive interstitial cells in mediating phasic contractions of bladder strips from streptozotocin-induced diabetic rats. BJU International, 107(9), 1480-1487. https://doi.org/10.1111/j.1464-410X.2010.09507.x

What's known on the subject? and What does the study add? Although the functional significance of ICCs in the bladder is still not clear, they have been linked with detrusor overactivity. In this study we demonstrate the presence of c-kit positive in... Read More about The role of c-kit-positive interstitial cells in mediating phasic contractions of bladder strips from streptozotocin-induced diabetic rats.

Identification of c-kit positive cells in rat urinary bladder and characterization of their functional role in spontaneous activity in control and diabetic bladders (2008)
Journal Article
Vahabi, B., Mckay, N. G., Lawson, K., & Sellers, D. J. (2008). Identification of c-kit positive cells in rat urinary bladder and characterization of their functional role in spontaneous activity in control and diabetic bladders. European Urology Supplements, 7(3), 181 - 181. https://doi.org/10.1016/S1569-9056%2807%2960992-0