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Population implications of cessation of IVF during the COVID-19 pandemic (2020)
Journal Article
Smith, A., Gromski, P., Al Rashid, K., Tilling, K., Lawlor, D., & Nelson, S. M. (in press). Population implications of cessation of IVF during the COVID-19 pandemic. Reproductive BioMedicine Online, https://doi.org/10.1016/j.rbmo.2020.07.002

Research Question Discontinuation of in vitro fertilisation (IVF) cycles has been part of the radical transformation of healthcare provision to enable reallocation of staff and resources to deal with the COVID-19 pandemic. We sought to estimate the... Read More about Population implications of cessation of IVF during the COVID-19 pandemic.

The mental health effects of pet death during childhood: Is it better to have loved and lost than never to have loved at all? (2020)
Journal Article
Crawford, K., Zhu, Y., Davis, K., Ernst, S., Jacobsson, K., Nishimi, K., …Dunn, E. (in press). The mental health effects of pet death during childhood: Is it better to have loved and lost than never to have loved at all?. European Child and Adolescent Psychiatry,

Background: Pet ownership is common. Growing evidence suggests children form deep emotional attachments to their pets. Yet, little is known about children’s emotional reactions to a pet’s death. Aims: To describe the relationship between experie... Read More about The mental health effects of pet death during childhood: Is it better to have loved and lost than never to have loved at all?.

Live birth rates and perinatal outcomes when all embryos are frozen compared with conventional fresh and frozen embryo transfer: a cohort study of 337,148 in vitro fertilisation cycles (2019)
Journal Article
Smith, A., Tilling, K., Lawlor, D., & Nelson, S. (2019). Live birth rates and perinatal outcomes when all embryos are frozen compared with conventional fresh and frozen embryo transfer: a cohort study of 337,148 in vitro fertilisation cycles. BMC Medicine, 17(1), https://doi.org/10.1186/s12916-019-1429-z

BACKGROUND: It is not known whether segmentation of an in vitro fertilisation (IVF) cycle, with freezing of all embryos prior to transfer, increases the chance of a live birth after all embryos are transferred. METHODS: In a prospective study of UK H... Read More about Live birth rates and perinatal outcomes when all embryos are frozen compared with conventional fresh and frozen embryo transfer: a cohort study of 337,148 in vitro fertilisation cycles.

Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children (2019)
Journal Article
Marini, S., Davis, K. A., Soare, T. W., Zhu, Y., Suderman, M. J., Simpkin, A. J., …Dunn, E. C. (2020). Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children. Psychoneuroendocrinology, 113, https://doi.org/10.1016/j.psyneuen.2019.104484

Objectives: Exposure to adversity has been linked to accelerated biological aging, which in turn has been shown to predict numerous physical and mental health problems. In recent years, measures of DNA methylation-based epigenetic age––known as “epig... Read More about Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children.

Adolescent body dissatisfaction and disordered eating: Predictors of later risky health behaviours (2019)
Journal Article
Bornioli, A., Lewis-Smith, H., Smith, A., Slater, A., & Bray, I. (2019). Adolescent body dissatisfaction and disordered eating: Predictors of later risky health behaviours. Social Science and Medicine, 238, https://doi.org/10.1016/j.socscimed.2019.112458

Rationale Body dissatisfaction is prevalent among teenagers, and may influence the uptake of risky health behaviours. Objective The study assessed the influence of body dissatisfaction on smoking, cannabis use, drug use, self-harm, gambling, and... Read More about Adolescent body dissatisfaction and disordered eating: Predictors of later risky health behaviours.

Adolescent body dissatisfaction as public health issue: Effects on later risky health behaviours (2019)
Presentation / Conference
Bornioli, A., Lewis-Smith, H., Smith, A., Slater, A., & Bray, I. (2019, March). Adolescent body dissatisfaction as public health issue: Effects on later risky health behaviours. Paper presented at South West Public Health Scientific Conference 2019

Aim: Body dissatisfaction is prevalent among teenagers, and may influence the uptake of risky health behaviours. The study assessed the influence of body dissatisfaction on smoking, cannabis use, drug use, self-harm, gambling, and drinking and the me... Read More about Adolescent body dissatisfaction as public health issue: Effects on later risky health behaviours.

Sensitive periods for the effect of childhood adversity on DNA methylation: Results from a prospective, longitudinal study (2019)
Journal Article
Dunn, E. C., Soare, T. W., Zhu, Y., Simpkin, A. J., Suderman, M. J., Klengel, T., …Relton, C. L. (2019). Sensitive periods for the effect of childhood adversity on DNA methylation: Results from a prospective, longitudinal study. Biological Psychiatry, 85(10), 838-849. https://doi.org/10.1016/j.biopsych.2018.12.023

Background: Exposure to "early life" adversity is known to predict DNA methylation (DNAm) patterns that may be related to psychiatric risk. However, few studies have investigated whether adversity has time-dependent effects based on the age at exposu... Read More about Sensitive periods for the effect of childhood adversity on DNA methylation: Results from a prospective, longitudinal study.

Exposure to childhood adversity and deficits in emotion recognition: results from a large, population-based sample (2018)
Journal Article
Dunn, E. C., Crawford, K. M., Soare, T. W., Button, K. S., Raffeld, M. R., Smith, A. D. A. C., …Munafò, M. R. (2018). Exposure to childhood adversity and deficits in emotion recognition: results from a large, population-based sample. Journal of Child Psychology and Psychiatry, 59(8), 845-854. https://doi.org/10.1111/jcpp.12881

© 2018 Association for Child and Adolescent Mental Health. Background: Emotion recognition skills are essential for social communication. Deficits in these skills have been implicated in mental disorders. Prior studies of clinical and high-risk sampl... Read More about Exposure to childhood adversity and deficits in emotion recognition: results from a large, population-based sample.

What life course theoretical models best explain the relationship between exposure to childhood adversity and psychopathology symptoms: Recency, accumulation, or sensitive periods? (2018)
Journal Article
Dunn, E. C., Soare, T. W., Raffeld, M. R., Busso, D. S., Crawford, K. M., Fisher, V. A., …Susser, E. S. (2018). What life course theoretical models best explain the relationship between exposure to childhood adversity and psychopathology symptoms: Recency, accumulation, or sensitive periods?. Psychological Medicine, 48(15), 2562-2572. https://doi.org/10.1017/S0033291718000181

Copyright © Cambridge University Press 2018Â. Background Although childhood adversity is a potent determinant of psychopathology, relatively little is known about how the characteristics of adversity exposure, including its developmental timing or du... Read More about What life course theoretical models best explain the relationship between exposure to childhood adversity and psychopathology symptoms: Recency, accumulation, or sensitive periods?.

Maternal dietary patterns during pregnancy and intelligence quotients in the offspring at 8years of age: Findings from the ALSPAC cohort (2017)
Journal Article
Freitas Vilela, A. A., Pearson, R. M., Emmett, P., Heron, J., Smith, A. D. A. C., Emond, A., …Kac, G. (2018). Maternal dietary patterns during pregnancy and intelligence quotients in the offspring at 8years of age: Findings from the ALSPAC cohort. Maternal and Child Nutrition, 14(1), e12431. https://doi.org/10.1111/mcn.12431

© 2017 The Authors. Maternal & Child Nutrition Published by John Wiley & Sons Ltd Dietary intake during pregnancy may influence child neurodevelopment and cognitive function. This study aims to investigate the associations between dietary pattern... Read More about Maternal dietary patterns during pregnancy and intelligence quotients in the offspring at 8years of age: Findings from the ALSPAC cohort.

Programming of adiposity in childhood and adolescence: Associations with birth weight and cord blood adipokines (2017)
Journal Article
Nelson, S. M., Lawlor, D. A., Ring, S. M., Lindsay, R. S., Smith, A. D., Simpson, J., …Nelson, S. M. (2017). Programming of adiposity in childhood and adolescence: Associations with birth weight and cord blood adipokines. Journal of Clinical Endocrinology and Metabolism, 102(2), 499-506. https://doi.org/10.1210/jc.2016-2342

© 2017 by the Endocrine Society. Context: Exposure to maternal adiposity during pregnancy is associated with higher offspring birth weight and greater adiposity through childhood and adult life. As birth weight reflects the summation of lean and fat... Read More about Programming of adiposity in childhood and adolescence: Associations with birth weight and cord blood adipokines.

Joint modelling compared with two stage methods for analysing longitudinal data and prospective outcomes: A simulation study of childhood growth and BP (2017)
Journal Article
Smith, A. D., Sayers, A., Heron, J., Smith, A. D. A. C., Macdonald-Wallis, C., Gilthorpe, M. S., …Tilling, K. (2017). Joint modelling compared with two stage methods for analysing longitudinal data and prospective outcomes: A simulation study of childhood growth and BP. Statistical Methods in Medical Research, 26(1), 437-452. https://doi.org/10.1177/0962280214548822

© The Author(s) 2014. There is a growing debate with regards to the appropriate methods of analysis of growth trajectories and their association with prospective dependent outcomes. Using the example of childhood growth and adult BP, we conducted an... Read More about Joint modelling compared with two stage methods for analysing longitudinal data and prospective outcomes: A simulation study of childhood growth and BP.

Dietary patterns by cluster analysis in pregnant women: relationship with nutrient intakes and dietary patterns in 7-year-old offspring (2016)
Journal Article
Emmett, P. M., Hibbeln, J. R., Pearson, R. M., Smith, A. D., Freitas-Vilela, A. A., Vilela, A. A. F., …Emmett, P. M. (2017). Dietary patterns by cluster analysis in pregnant women: relationship with nutrient intakes and dietary patterns in 7-year-old offspring. Maternal and Child Nutrition, 13(2), e12353. https://doi.org/10.1111/mcn.12353

© 2016 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd. Little is known about how dietary patterns of mothers and their children track over time. The objectives of this study are to obtain dietary patterns in pregnancy... Read More about Dietary patterns by cluster analysis in pregnant women: relationship with nutrient intakes and dietary patterns in 7-year-old offspring.

Cord blood adipokines and lipids and adolescent nonalcoholic fatty liver disease (2016)
Journal Article
Nelson, S. M., Lindsay, R. S., Smith, A. D., Lawlor, D. A., Simpson, J., Smith, A. D. A. C., …Nelson, S. M. (2016). Cord blood adipokines and lipids and adolescent nonalcoholic fatty liver disease. Journal of Clinical Endocrinology and Metabolism, 101(12), 4661-4668. https://doi.org/10.1210/jc.2016-2604

© 2016 by the Endocrine Society. Context: Maternal adiposity in pregnancy is associated with offspring adiposity and metabolic dysfunction postnatally, including greater risk of nonalcoholic fatty liver disease (NAFLD). Recent genetic analyses sugges... Read More about Cord blood adipokines and lipids and adolescent nonalcoholic fatty liver disease.

A structured approach to hypotheses involving continuous exposures over the life course (2016)
Journal Article
Lawlor, D. A., Joinson, C. J., Smith, A. D., Smith, A. D. A. C., Hardy, R., Heron, J., …Tilling, K. (2016). A structured approach to hypotheses involving continuous exposures over the life course. International Journal of Epidemiology, 45(4), 1271-1279. https://doi.org/10.1093/ije/dyw164

© The Author 2016. Published by Oxford University Press on behalf of the International Epidemiological Association. Background: Epidemiologists are often interested in examining different hypotheses for how exposures measured repeatedly over the life... Read More about A structured approach to hypotheses involving continuous exposures over the life course.

Relationship between mediation analysis and the structured life course approach (2016)
Journal Article
Lawlor, D. A., Anderson, E. L., Smith, A. D., Howe, L. D., Howe, L. D., Smith, A. D. A. C., …Fraser, A. (2016). Relationship between mediation analysis and the structured life course approach. International Journal of Epidemiology, 45(4), 1280-1294. https://doi.org/10.1093/ije/dyw254

© The Author 2016. Published by Oxford University Press on behalf of the International Epidemiological Association. Many questions in life course epidemiology involve mediation and/or interaction because of the long latency period between exposures a... Read More about Relationship between mediation analysis and the structured life course approach.

Live-birth rate associated with repeat in vitro fertilization treatment cycles (2015)
Journal Article
Smith, A. D., Smith, A. D. A. C., Tilling, K., Nelson, S. M., & Lawlor, D. A. (2015). Live-birth rate associated with repeat in vitro fertilization treatment cycles. Journal of the American Medical Association, 314(24), 2654-2662. https://doi.org/10.1001/jama.2015.17296

© 2015 American Medical Association. All rights reserved. Importance The likelihood of achieving a live birth with repeat in vitro fertilization (IVF) is unclear, yet treatment is commonly limited to 3 or 4 embryo transfers. Objective To determine th... Read More about Live-birth rate associated with repeat in vitro fertilization treatment cycles.

Model selection of the effect of binary exposures over the life course (Epidemiology (2015) 26 (719-726)) (2015)
Journal Article
Smith, A. D. A. C., Heron, J., Mishra, G., Gilthorpe, M. S., Ben-Shlomo, Y., & Tilling, K. (2015). Model selection of the effect of binary exposures over the life course (Epidemiology (2015) 26 (719-726)). Epidemiology, 26(6), e69. https://doi.org/10.1097/EDE.0000000000000348

Copyright © 2015 Wolters Kluwer Health, Inc. The following three figures were omitted from a paper by Smith et al. in the September 2015 issue of Epidemiology. The paper is titled, "Model Selection of the Effect of Binary Exposures over the Life Cour... Read More about Model selection of the effect of binary exposures over the life course (Epidemiology (2015) 26 (719-726)).

External validation and calibration of IVFpredict: A national prospective cohort study of 130,960 in vitro fertilisation cycles (2015)
Journal Article
Smith, A. D. A. C., Tilling, K., Lawlor, D. A., & Nelson, S. M. (2015). External validation and calibration of IVFpredict: A national prospective cohort study of 130,960 in vitro fertilisation cycles. PLoS ONE, 10(4), e0121357. https://doi.org/10.1371/journal.pone.0121357

Background Accurately predicting the probability of a live birth after in vitro fertilisation (IVF) is important for patients, healthcare providers and policy makers. Two prediction models (Templeton and IVFpredict) have been previously developed fr... Read More about External validation and calibration of IVFpredict: A national prospective cohort study of 130,960 in vitro fertilisation cycles.

Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: Findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) (2014)
Journal Article
Smith, G. D., Smith, A. D., Richmond, R. C., Simpkin, A. J., Woodward, G., Gaunt, T. R., …Relton, C. L. (2015). Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: Findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). Human Molecular Genetics, 24(8), 2201-2217. https://doi.org/10.1093/hmg/ddu739

© The Author 2014. Maternal smoking during pregnancy has been found to influence newborn DNA methylation in genes involved in fundamental developmental processes. It is pertinent to understand the degree to which the offspring methylomeis sensitive t... Read More about Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: Findings from the Avon Longitudinal Study of Parents and Children (ALSPAC).


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