All Outputs (2)

The effect of a clinically effective and non-effective dose of lorazepam on 7.5% CO2-induced anxiety (2012)
Journal Article
Diaper, A., Papadopoulos, A., Rich, A. S., Dawson, G. R., Dourish, C. T., Nutt, D. J., & Bailey, J. E. (2012). The effect of a clinically effective and non-effective dose of lorazepam on 7.5% CO2-induced anxiety. Human Psychopharmacology: Clinical and Experimental, 27(6), 540-548. https://doi.org/10.1002/hup.2261

Symptoms of anxiety induced by 7.5% CO2 inhalation can be attenuated by acute administration of GABAA receptor anxiolytics such as lorazepam and alprazolam. This study investigated if these effects are dose-related, by comparing a 0.5 mg dose (consid... Read More about The effect of a clinically effective and non-effective dose of lorazepam on 7.5% CO2-induced anxiety.

Evaluation of the effects of venlafaxine and pregabalin on the carbon dioxide inhalation models of Generalised Anxiety Disorder and panic (2012)
Journal Article
Diaper, A., Osman-Hicks, V., Rich, A. S., Craig, K., Dourish, C. T., Dawson, G. R., …Bailey, J. E. (2013). Evaluation of the effects of venlafaxine and pregabalin on the carbon dioxide inhalation models of Generalised Anxiety Disorder and panic. Journal of Psychopharmacology, 27(2), 135-145. https://doi.org/10.1177/0269881112443742

Previous studies have shown that subjective and objective symptoms of anxiety induced by 7.5% CO2 inhalation can be attenuated by anxiolytics such as lorazepam and, to a lesser extent, paroxetine. Venlafaxine and pregabalin, two other licensed treatm... Read More about Evaluation of the effects of venlafaxine and pregabalin on the carbon dioxide inhalation models of Generalised Anxiety Disorder and panic.