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Volatile organic compounds as diagnostic biomarkers in gastrointestinal and liver diseases

Probert, C. S. J.; Khalid, Tanzeela; Ahmed, Iftikhar; Johnson, Edward; Smith, S; Ratcliffe, Norman M.

Authors

C. S. J. Probert

Tanzeela Khalid tanzeela2.khalid@uwe.ac.uk

Iftikhar Ahmed

Edward Johnson

S Smith



Abstract

The assessment of disease activity in various conditions may be performed using a range of different techniques. These include the use of non-invasive tests, such as acute phase inflammatory markers and simple radiological techniques, to more advanced invasive and complex modalities. Over the past two decades the analysis of volatile organic compounds (VOCs) in biological specimens has attracted a considerable amount of clinical interest. The investigation of VOCs, using a variety of analytical techniques, has shown a significant correlation between the pattern and concentration of VOCs and the occurrence of various diseases. This provides a potentially non-invasive means of diagnosis, monitoring of pathological processes and assessment of pharmacological response. It may be rapid, simple and acceptable to patients. In this paper we review the medical literature and research efforts that have been carried out over the past decades, and try to summarize the clinical implications of VOC analysis of various biological emanations including stool, breath and blood samples and their correlation with gastrointestinal and liver diseases.

Journal Article Type Article
Publication Date Sep 1, 2009
Journal Journal of Gastrointestinal and Liver Disease
Print ISSN 1842-1121
Peer Reviewed Peer Reviewed
Volume 18
Issue 3
Pages 337-343
APA6 Citation Probert, C. S. J., Khalid, T., Ahmed, I., Johnson, E., Smith, S., & Ratcliffe, N. M. (2009). Volatile organic compounds as diagnostic biomarkers in gastrointestinal and liver diseases. Journal of Gastrointestinal and Liver Diseases, 18(3), 337-343
Keywords volatile organic compounds, diagnostic biomarkers, gastrointestinal and liver diseases
Publisher URL http://www.jgld.ro/2009/3/12.html

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