Gillian Prue
Fatigue in Gynecological Cancer Patients During and After Anticancer Treatment
Prue, Gillian; Allen, James; Gracey, Jacqueline; Rankin, Jane; Cramp, Fiona (Alice)
Authors
James Allen
Jacqueline Gracey
Jane Rankin
Fiona Cramp Fiona.Cramp@uwe.ac.uk
Professor in Long Term Conditions
Abstract
Context: Research has indicated that individuals with gynecological cancer experience severe fatigue. Objectives: This longitudinal survey aimed to analyze the fatigue experienced over the course of one year by a gynecological cancer population, to determine if the fatigue was more severe than that reported by females without cancer, and to identify variables associated with cancer-related fatigue (CRF). Methods: Data were collected over a 12-month period before, during, and after anticancer treatment. Fatigue was assessed using the Multidimensional Fatigue Symptom Inventory-Short Form. Participants with cancer also completed the Rotterdam Symptom Checklist. Results: Sixty-five cancer patients (mean age = 57.4 years, standard deviation [SD] = 13.9) and 60 control subjects (mean age = 55.4 years, SD = 13.6) participated. Descriptive analysis and repeated measurements modeling indicated that the cancer participants reported worse fatigue than the noncancer individuals before, during, and after anticancer treatment (P < 0.001) and that the level of fatigue in persons with cancer changed with time (P = 0.02). A forward stepwise regression demonstrated that psychological distress level was the only independent predictor of CRF during anticancer treatment (P < 0.00), explaining 44% of the variance in fatigue. After treatment, both psychological distress level (P < 0.00) and physical symptom distress (P = 0.03) were independent predictors of fatigue, accounting for 81% of the variance. Conclusion: Psychological distress level is an important indicator of CRF in gynecological cancer. Interventions focused on the reduction of psychological distress may help alleviate CRF. © 2010 U.S. Cancer Pain Relief Committee.
Citation
Prue, G., Allen, J., Gracey, J., Rankin, J., & Cramp, F. (. (2010). Fatigue in Gynecological Cancer Patients During and After Anticancer Treatment. Journal of Pain and Symptom Management, 39(2), 197-210. https://doi.org/10.1016/j.jpainsymman.2009.06.011
Journal Article Type | Article |
---|---|
Publication Date | Feb 1, 2010 |
Publicly Available Date | Jun 8, 2019 |
Journal | Journal of Pain and Symptom Management |
Print ISSN | 0885-3924 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 39 |
Issue | 2 |
Pages | 197-210 |
DOI | https://doi.org/10.1016/j.jpainsymman.2009.06.011 |
Keywords | Fatigue, neoplasm, gynecological, symptoms, adult |
Public URL | https://uwe-repository.worktribe.com/output/981643 |
Publisher URL | http://dx.doi.org/10.1016/j.jpainsymman.2009.06.011 |
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