J. Martin
Effect of dietary fatty acids on expression of lipogenic enzymes and fatty acid profile in tissues of bulls
Martin, J.; Herdmann, A.; Martin, K.; Nuernberg, K.; Doran, Olena; Nuernberg, G.
Authors
A. Herdmann
K. Martin
K. Nuernberg
Olena Doran Olena.Doran@uwe.ac.uk
College Dean of Research and Enterprise
G. Nuernberg
Abstract
This study investigated the effects of dietary linolenic acid (C18:3n-3) v. linoleic acid (C18:2n-6) on fatty acid composition and protein expression of key lipogenic enzymes, acetyl-CoA carboxylase (ACC), stearoyl-CoA desaturase (SCD) and delta 6 desaturase (6d) in longissimus muscle and subcutaneous adipose tissue of bulls. Supplementation of the diet with C18:3n-3 was accompanied by an increased level of n-3 fatty acids in muscle which resulted in decrease of n-6/n-3 ratio. The diet enriched with n-3 polyunsaturated fatty acids (PUFAs) significantly inhibited SCD protein expression in muscle and subcutaneous adipose tissue, and reduced the 6d expression in muscle. There was no significant effect of the diet on ACC protein expression. Inhibition of the 6d expression was associated with a decrease in n-6 PUFA level in muscles, whereas repression of SCD protein was related to a lower oleic acid (C18:1 cis-9) content in the adipose tissue. Expression of ACC, SCD and 6d proteins was found to be relatively higher in subcutaneous adipose tissue when compared with longissimus muscle. It is suggested that dietary manipulation of fatty acid composition in ruminants is mediated, at least partially, through the regulation of lipogenic enzymes expression and that regulation of the bovine lipogenic enzymes expression is tissue specific. © 2010 The Animal Consortium.
Citation
Martin, J., Herdmann, A., Nuernberg, K., Martin, K., Nuernberg, G., & Doran, O. (2010). Effect of dietary fatty acids on expression of lipogenic enzymes and fatty acid profile in tissues of bulls. animal, 4(5), 755-762. https://doi.org/10.1017/S1751731110000431
Journal Article Type | Article |
---|---|
Publication Date | Mar 16, 2010 |
Deposit Date | Jun 21, 2010 |
Publicly Available Date | Mar 29, 2024 |
Journal | Animal |
Print ISSN | 1751-7311 |
Electronic ISSN | 1751-732X |
Publisher | Cambridge University Press (CUP) |
Peer Reviewed | Peer Reviewed |
Volume | 4 |
Issue | 5 |
Pages | 755-762 |
DOI | https://doi.org/10.1017/S1751731110000431 |
Keywords | diet, enzyme expression, fatty acid, lipogenic enzyme |
Public URL | https://uwe-repository.worktribe.com/output/980519 |
Publisher URL | http://dx.doi.org/10.1017/S1751731110000431 |
Additional Information | Additional Information : Copyright © The Animal Consortium 2010 |
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