Skip to main content

Research Repository

Advanced Search

Effect of dietary fatty acids on expression of lipogenic enzymes and fatty acid profile in tissues of bulls

Martin, J.; Herdmann, A.; Martin, K.; Nuernberg, K.; Doran, Olena; Nuernberg, G.

Effect of dietary fatty acids on expression of lipogenic enzymes and fatty acid profile in tissues of bulls Thumbnail


Authors

J. Martin

A. Herdmann

K. Martin

K. Nuernberg

Olena Doran Olena.Doran@uwe.ac.uk
College Dean of Research and Enterprise

G. Nuernberg



Abstract

This study investigated the effects of dietary linolenic acid (C18:3n-3) v. linoleic acid (C18:2n-6) on fatty acid composition and protein expression of key lipogenic enzymes, acetyl-CoA carboxylase (ACC), stearoyl-CoA desaturase (SCD) and delta 6 desaturase (6d) in longissimus muscle and subcutaneous adipose tissue of bulls. Supplementation of the diet with C18:3n-3 was accompanied by an increased level of n-3 fatty acids in muscle which resulted in decrease of n-6/n-3 ratio. The diet enriched with n-3 polyunsaturated fatty acids (PUFAs) significantly inhibited SCD protein expression in muscle and subcutaneous adipose tissue, and reduced the 6d expression in muscle. There was no significant effect of the diet on ACC protein expression. Inhibition of the 6d expression was associated with a decrease in n-6 PUFA level in muscles, whereas repression of SCD protein was related to a lower oleic acid (C18:1 cis-9) content in the adipose tissue. Expression of ACC, SCD and 6d proteins was found to be relatively higher in subcutaneous adipose tissue when compared with longissimus muscle. It is suggested that dietary manipulation of fatty acid composition in ruminants is mediated, at least partially, through the regulation of lipogenic enzymes expression and that regulation of the bovine lipogenic enzymes expression is tissue specific. © 2010 The Animal Consortium.

Citation

Martin, J., Herdmann, A., Nuernberg, K., Martin, K., Nuernberg, G., & Doran, O. (2010). Effect of dietary fatty acids on expression of lipogenic enzymes and fatty acid profile in tissues of bulls. animal, 4(5), 755-762. https://doi.org/10.1017/S1751731110000431

Journal Article Type Article
Publication Date Mar 16, 2010
Deposit Date Jun 21, 2010
Publicly Available Date Mar 29, 2024
Journal Animal
Print ISSN 1751-7311
Electronic ISSN 1751-732X
Publisher Cambridge University Press (CUP)
Peer Reviewed Peer Reviewed
Volume 4
Issue 5
Pages 755-762
DOI https://doi.org/10.1017/S1751731110000431
Keywords diet, enzyme expression, fatty acid, lipogenic enzyme
Public URL https://uwe-repository.worktribe.com/output/980519
Publisher URL http://dx.doi.org/10.1017/S1751731110000431
Additional Information Additional Information : Copyright © The Animal Consortium 2010

Files





You might also like



Downloadable Citations