David G. Spiller
Dynamic NF-κb and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation
Spiller, David G.; Ankers, John M.; Jackson, Dean A.; Jones, Nicholas A.; White, Michael R.H.; Adamson, Antony D.; Harper, Claire V.; Ankers, John M; Jones, Nicholas A; Adamson, Antony D; Harper, Claire V; Awais, Raheela; Spiller, David G; Jackson, Dean A; Boyd, James; Ryan, Sheila; White, Michael RH; Bridge, Lloyd; Paszek, Pawel; S�e, Violaine
Authors
John M. Ankers
Dean A. Jackson
Nicholas A. Jones
Michael R.H. White
Antony D. Adamson
Claire V. Harper
John M Ankers
Nicholas A Jones
Antony D Adamson
Claire V Harper
Raheela Awais
David G Spiller
Dean A Jackson
James Boyd
Sheila Ryan
Michael RH White
Lloyd Bridge Lloyd.Bridge@uwe.ac.uk
Senior Lecturer in Mathematics
Pawel Paszek
Violaine S�e
Abstract
© Ankers et al. Dynamic cellular systems reprogram gene expression to ensure appropriate cellular fate responses to specific extracellular cues. Here we demonstrate that the dynamics of Nuclear Factor kappa B (NF-κB) signalling and the cell cycle are prioritised differently depending on the timing of an inflammatory signal. Using iterative experimental and computational analyses, we show physical and functional interactions between NF-κB and the E2 Factor 1 (E2F-1) and E2 Factor 4 (E2F-4) cell cycle regulators. These interactions modulate the NF-κB response. In S-phase, the NF-κB response was delayed or repressed, while cell cycle progression was unimpeded. By contrast, activation of NF-κB at the G1/S boundary resulted in a longer cell cycle and more synchronous initial NF-κB responses between cells. These data identify new mechanisms by which the cellular response to stress is differentially controlled at different stages of the cell cycle.
Citation
Harper, C. V., Adamson, A. D., White, M. R., Jones, N. A., Jackson, D. A., Ankers, J. M., …White, M. R. (2016). Dynamic NF-κb and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation. eLife, 5(MAY2016), https://doi.org/10.7554/eLife.10473
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 13, 2016 |
Publication Date | May 17, 2016 |
Journal | eLife |
Electronic ISSN | 2050-084X |
Publisher | eLife Sciences Publications |
Peer Reviewed | Peer Reviewed |
Volume | 5 |
Issue | MAY2016 |
DOI | https://doi.org/10.7554/eLife.10473 |
Public URL | https://uwe-repository.worktribe.com/output/916426 |
Publisher URL | http://dx.doi.org/10.7554/eLife.10473 |
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