A randomised controlled feasibility and proof-of-concept trial in delayedgastric emptying when metoclopramide fails: We should revisitnasointestinal feeding versus dual prokinetic treatment: Achieving goal nutrition in critical illness and delayed gastric emptying: Trial of nasointestinal feeding versus nasogastric feeding plus prokinetics

Taylor, Stephen J.; Allan, Kaylee; McWilliam, Helen; Manara, Alex; Brown, Jules; Greenwood, Rosemary; Toher, Deirdre

Abstract

© 2016 European Society for Clinical Nutrition and Metabolism Background & aims Delayed gastric emptying (DGE) commonly limits the use of enteral nutrition (EN) and may increase ventilator-associated pneumonia. Nasointestinal feeding has not been tested against dual prokinetic treatment (Metoclopramide and Erythromycin) in DGE refractory to metoclopramide. This trial tests the feasibility of recruiting this ‘treatment-failed’ population and the proof of concept that nasointestinal (NI) feeding can increase the amount of feed tolerated (% goal) when compared to nasogastric (NG) feeding plus metoclopramide and erythromycin treatment. Methods Eligible patients were those who were mechanically ventilated and over 20 years old, with delayed gastric emptying (DGE), defined as a gastric residual volume ≥250ml or vomiting, and who failed to respond to first-line prokinetic treatment of 3 doses of 10mg IV metoclopramide over 24h. When assent was obtained, patients were randomised to receive immediate nasointestinal tube placement and feeding or nasogastric feeding plus metoclopramide and erythromycin (prokinetic) treatment. Results Of 208 patients with DGE, 77 were eligible, 2 refused assent, 25 had contraindications to intervention, almost exclusively prokinetic treatment, and it was feasible to recruit 50. Compared to patients receiving prokinetics (n=25) those randomised to nasointestinal feeding (n=25) tolerated more of their feed goal over 5 days (87–95% vs 50–89%) and had a greater area under the curve (median [IQR] 432 [253–464]% vs 350 [213–381]%, p=0.026) demonstrating proof of concept. However, nasointestinally fed patients also had a larger gastric loss (not feed) associated with the NI route but not with the fluid volume or energy delivered. Conclusions This is first study showing that in DGE refractory to metoclopramide NI feeding can increase the feed goal tolerated when compared to dual prokinetic treatment. Future studies should investigate the effect on clinical outcomes. EU Clinical trials register EudraCT number: 2012-001374-29.

Citation

Taylor, S. J., Allan, K., McWilliam, H., Manara, A., Brown, J., Greenwood, R., & Toher, D. (2016). A randomised controlled feasibility and proof-of-concept trial in delayedgastric emptying when metoclopramide fails: We should revisitnasointestinal feeding versus dual prokinetic treatment: Achieving goal nutrition in critical illness and delayed gastric emptying: Trial of nasointestinal feeding versus nasogastric feeding plus prokinetics. Clinical nutrition ESPEN, 14, 1-8. https://doi.org/10.1016/j.clnesp.2016.04.020

• Journal Article Type: Article
• Acceptance Date: Apr 8, 2016
• Online Publication Date: May 31, 2016
• Publication Date: Aug 1, 2016
• Deposit Date: Jun 9, 2016
• Publicly Available Date: May 31, 2017
• Journal: Clinical Nutrition ESPEN
• Print ISSN: 24054577
• Peer Reviewed: Peer Reviewed
• Volume: 14
• Pages: 1-8
• DOI: https://doi.org/10.1016/j.clnesp.2016.04.020
• Keywords: delayed gastric emptying, nasogastric, nasointestinal, prokinetic
• Public URL: https://uwe-repository.worktribe.com/output/909323
• Publisher URL: http://dx.doi.org/10.1016/j.clnesp.2016.04.020