Identifying biomechanical gait parameters in adolescent boys with haemophilia using principal component analysis

Suckling, Luke; Stephensen, David; Cramp, Mary; Mahaffey, Ryan; Drechsler, Wendy

Abstract

© 2017 John Wiley & Sons Ltd Introduction: Improvements in the medical management for those with haemophilia have resulted in improved clinical outcomes. However, current treatment regimens do not alleviate all joint haemarthroses with the potential for long-term joint deterioration remaining. The evaluation of functional activities such as gait, using standardized tools to monitor children with haemophilia is emerging. Aim: This study explored differences in sagittal plane biomechanics of walking in adolescent boys aged 11-18years with haemophilia and an age-matched group of typically developing boys. Methods: A motion capture system and 2 force platforms were used to collect sagittal plane kinematic, kinetic and temporal spatial data during level walking. Principal component analysis (PCA) was applied to kinematic and kinetic waveform variables. Group differences in temporal spatial and principal component scores for each kinematic and kinetic variable were evaluated using independent t tests. Results: Significant alterations (P

Citation

Suckling, L., Stephensen, D., Cramp, M., Mahaffey, R., & Drechsler, W. (2018). Identifying biomechanical gait parameters in adolescent boys with haemophilia using principal component analysis. Haemophilia, 24(1), 149-155. https://doi.org/10.1111/hae.13362

• Journal Article Type: Article
• Acceptance Date: Sep 24, 2017
• Online Publication Date: Nov 17, 2017
• Publication Date: Jan 1, 2018
• Deposit Date: Sep 26, 2017
• Publicly Available Date: Nov 17, 2018
• Journal: Haemophilia
• Print ISSN: 1351-8216
• Electronic ISSN: 1365-2516
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 24
• Issue: 1
• Pages: 149-155
• DOI: https://doi.org/10.1111/hae.13362
• Keywords: biomechanics, gait, haemophilia, principle components analysis, boys
• Public URL: https://uwe-repository.worktribe.com/output/876075
• Publisher URL: http://dx.doi.org/10.1111/hae.13362
• Additional Information: Additional Information : This is the peer reviewed version of the following article: Suckling, L., Stephensen, D., Cramp, M., Mahaffey, R. and Drechsler, W. (2017) Identifying biomechanical gait parameters in adolescent boys with haemophilia using principal component analysis. Haemophilia. , which has been published in final form at http://dx.doi.org/10.1111/hae.13362. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.