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Core–shell PVA/gelatin nanofibrous scaffolds using co-solvent, aqueous electrospinning: Toward a green approach

Sengor, Mustafa; Ozgun, Alp; Corapcioglu, Gulcan; Ipekoglu, Mehmet; Garipcan, Bora; Ersoy, Nuri; Altintas, Sabri

Authors

Mustafa Sengor

Alp Ozgun

Gulcan Corapcioglu

Mehmet Ipekoglu

Bora Garipcan

Nuri Ersoy Nuri3.Ersoy@uwe.ac.uk
Senior Lecturer in Mechanical Engineering

Sabri Altintas



Abstract

© 2018 Wiley Periodicals, Inc. Electrospinning (ES) of gelatin often requires cytotoxic organic solvents or acidic environments, which deteriorate cell recognition sites. In this study, aqueous, non-toxic, co-solvent ES was performed to obtain core–shell poly(vinyl alcohol) (PVA)/gelatin nanofiber scaffolds. Effects of the core/shell feed rate ratio (FRR) were investigated on a morphological and mechanical basis. PVA:gelatin ratio of 1:4 was the limiting ratio for specific voltage and electrode distance parameters to obtain uniform fibers. Core–shell bead-free structures were obtained at 8% PVA and gelatin aqueous solutions. A mean diameter of 280 nm was obtained for 1:1 FRR at 15 kV and 15 cm of electrode distance. Crosslinking resulted in slight improvement in tensile strengths and severe decrease in ductility. Fourier transform infrared spectra revealed retention and improvement of stable secondary structures of gelatin after ES. The scaffolds almost degraded more than 60% in 14 days. Based on the results, present scaffolds hold great promise as suitable candidates for biomedical applications. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46582.

Citation

Sengor, M., Ozgun, A., Corapcioglu, G., Ipekoglu, M., Garipcan, B., Ersoy, N., & Altintas, S. (2018). Core–shell PVA/gelatin nanofibrous scaffolds using co-solvent, aqueous electrospinning: Toward a green approach. Journal of Applied Polymer Science, 135(32), 46582. https://doi.org/10.1002/app.46582

Journal Article Type Article
Acceptance Date Apr 7, 2018
Online Publication Date May 2, 2018
Publication Date Aug 20, 2018
Journal Journal of Applied Polymer Science
Print ISSN 0021-8995
Electronic ISSN 1097-4628
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 135
Issue 32
Pages 46582
DOI https://doi.org/10.1002/app.46582
Keywords biodegradable, biomaterials, biomedical applications, electrospinning, fibers
Public URL https://uwe-repository.worktribe.com/output/862818
Publisher URL http://dx.doi.org/10.1002/app.46582
Additional Information Additional Information : This is the peer reviewed version of the following article: [Sengor, M. , Ozgun, A. , Corapcioglu, G. , Ipekoglu, M. , Garipcan, B. , Ersoy, N. and Altintas, S. (2018) Core-shell PVA/gelatin nanofibrous scaffolds using co-solvent, aqueous electrospinning: Toward a green approach. Journal of Applied Polymer Science, 135 (32). p. 46582. ISSN 0021-8995], which has been published in final form at http://dx.doi.org/10.1002/app.46582. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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