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Equations to support redox experimentation

Hancock, John T.; Whiteman, Matthew

Authors

Matthew Whiteman



Contributors

Abstract

© Springer Science+Business Media, LLC, part of Springer Nature 2019. Working with redox compounds needs to take into account the oxidation and reduction state of the compound under study. This redox state can be influenced by the media in which the compound is found, but will also be influenced by local environments. For example, this may be dictated perhaps by the locality of amino acids in the three dimensional structure of a protein. Therefore, historically, equations have been developed to enable either the redox poise of the environment to be determined, or the redox state of the compound of interest. If a compound is found in the wrong redox state—perhaps inactive—in a cell this has significant ramifications for its role, for example in cell signaling. Here, the use of such equations is discussed, with examples of the relevance to modern redox biology.

Journal Methods in Molecular Biology
Peer Reviewed Not Peer Reviewed
Volume 1990
Pages 183-195
Series Title Methods in Molecular Biology
Series Number 1990
Book Title Redox-Mediated Signal Transduction
ISBN 97814939-94618
APA6 Citation Hancock, J. T., & Whiteman, M. Equations to support redox experimentation. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction, (183-195). Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9463-2_15
DOI https://doi.org/10.1007/978-1-4939-9463-2_15
Keywords apoptosis cytochrome, hydrogen peroxide, hydrogen sulfide, Nernst equation, redox couple, redox environment, redox state, thiol modifications
Publisher URL http://dx.doi.org/10.1007/978-1-4939-9463-2_15
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