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The South West Area Mesothelioma and Pemetrexed trial - A multi-centre prospective observational study evaluating novel markers of chemotherapy response and prognostication

Lowndes, S. A.; White, P.; Hooper, C. E.; Lyburn, I. D.; Searle, J.; Darby, M.; Hall, T.; Hall, D.; Morley, A.; White, Paul; Rahman, N. M.; De Winton, E.; Clive, A.; Masani, V.; Arnold, D. T.; Dangoor, A.; Guglani, S.; Jankowska, P.; Lowndes, P; Harvey, J. E.; Braybrooke, J. P.; Maskell, N. A.


S. A. Lowndes

P. White

C. E. Hooper

I. D. Lyburn

J. Searle

M. Darby

T. Hall

D. Hall

A. Morley

Paul White
Professor in Applied Statistics

N. M. Rahman

E. De Winton

A. Clive

V. Masani

D. T. Arnold

A. Dangoor

S. Guglani

P. Jankowska

P Lowndes

J. E. Harvey

J. P. Braybrooke

N. A. Maskell


© 2015 Cancer Research UK. All rights reserved. Background: Robust markers that predict prognosis and detect early treatment response in malignant pleural mesothelioma (MPM) would enhance patient care. Methods: Consecutive patients with MPM who were considered fit for first-line chemotherapy were prospectively recruited. Patients of similar performance status opting for best supportive care were included as a comparator group. Baseline and interval CT, PET-CT and serum markers (mesothelin, fibulin-3 and neutrophil-lymphocyte ratio (NLR)) were obtained, and patients followed up for a minimum 12 months. Findings: Seventy-three patients were recruited (58 chemotherapy/15 comparator arm). Baseline TGV (total glycolytic volume on PET-CT) was an independent predictor of worse overall survival (OS) (P=0.001). Change in interval TGV(baseline/after two cycles of chemotherapy) did not predict OS or chemotherapy response on CT. Baseline NLR


Lowndes, S. A., White, P., Hooper, C. E., Lyburn, I. D., Searle, J., Darby, M., …Maskell, N. A. (2015). The South West Area Mesothelioma and Pemetrexed trial: A multicentre prospective observational study evaluating novel markers of chemotherapy response and prognostication. British Journal of Cancer, 112(7), 1175-1182.

Journal Article Type Article
Publication Date Jan 1, 2015
Journal British Journal of Cancer
Print ISSN 0007-0920
Publisher Springer Nature [academic journals on]
Peer Reviewed Peer Reviewed
Volume 112
Issue 7
Pages 1175-1182
Keywords chemotherapy, response and prognostication, SWAMP, observational study
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