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Multimodal neurophysiological evaluation of primary progressive multiple sclerosis - An increasingly valid biomarker, with limits

Canham, L. J.W.; Kane, N.; Oware, A.; Walsh, P.; Blake, K.; Inglis, K.; Homewood, J.; Witherick, J.; Faulkner, H.; White, Paul; Lewis, A.; Furse-Roberts, C.; Cottrell, D. A.

Authors

L. J.W. Canham

N. Kane

A. Oware

P. Walsh

K. Blake

K. Inglis

J. Homewood

J. Witherick

H. Faulkner

Paul White Paul.White@uwe.ac.uk
Associate Professor in Applied Statistics

A. Lewis

C. Furse-Roberts

D. A. Cottrell



Abstract

© 2015 Elsevier B.V. Background The promising utility of multi-modality evoked potential batteries to objectively measure multi-tract dysfunction has been evaluated by several groups using different methods. Objective To independently evaluate the use of multi-modality evoked potential batteries as surrogate biomarkers for both physical and cognitive status in a cohort of Primary Progressive Multiple Sclerosis patients and identify the most potentially useful scoring method of those described. Methods 28 Patients with Primary Progressive Multiple Sclerosis underwent clinical evaluation with Kurtzke's Modified EDSS and the Multiple Sclerosis Functional Composite (MSFC). 19 Participants also underwent the Minimal Assessment of Cognitive Function in Multiple Sclerosis. Visual, Brainstem Auditory, Somatosensory and Motor Evoked Potentials were recorded on all. Results were graded by variants of the Global Evoked Potential Score, Multiple Evoked Potential Score and Summation of Z transformed Evoked Potential Latencies for correlation against the clinical scores. Conclusions Multi-modal evoked potential batteries generally show moderate and useful correlation with clinical status as measured by the regulatory standard of EDSS (r=.65 vs. mEPS p

Journal Article Type Article
Publication Date Jan 1, 2015
Journal Multiple Sclerosis and Related Disorders
Print ISSN 2211-0348
Electronic ISSN 2211-0356
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 4
Issue 6
Pages 607-613
Institution Citation White, P., Canham, L. J., Kane, N., Oware, A., Walsh, P., Blake, K., …Cottrell, D. A. (2015). Multimodal neurophysiological evaluation of primary progressive multiple sclerosis - An increasingly valid biomarker, with limits. Multiple Sclerosis and Related Disorders, 4(6), 607-613. https://doi.org/10.1016/j.msard.2015.07.009
DOI https://doi.org/10.1016/j.msard.2015.07.009
Keywords multiple sclerosis, primary progressive, evoked potential, biomarker
Publisher URL http://dx.doi.org/10.1016/j.msard.2015.07.009