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Endotracheal tubes and fluid aspiration: An in vitro evaluation of new cuff technologies

Mariyaselvam, Maryanne Z.; Marsh, Lucy L.; Bamford, Sarah; Smith, Ann; Wise, Matt P.; Williams, David W.

Authors

Maryanne Z. Mariyaselvam

Lucy L. Marsh

Sarah Bamford

Ann Smith

Matt P. Wise

David W. Williams



Abstract

© 2017 The Author(s). Background: Aspiration of subglottic secretions past the endotracheal tube (ETT) cuff is a prerequisite for developing ventilator-associated pneumonia (VAP). Subglottic secretion drainage (SSD) ETTs reduce aspiration of subglottic secretions and have demonstrated lower VAP rates. We compared the performance of seven SSD ETTs against a non-SSD ETT in preventing aspiration below inflated cuffs. Methods: ETTs were positioned vertically in 2 cm diameter cylinders. Four ml of a standard microbial suspension was added above inflated cuffs. After 1 h, aspiration was measured and ETTs demonstrating no leakage were subjected to rotational movement and evaluation over 24 h. Collected aspirated fluid was used to inoculate agar media and incubated aerobically at 37 °C for 24 h. The aspiration rate, volume and number of microorganisms that leaked past the cuff was measured. Experiments were repeated (×10) for each type of ETT, with new ETTs used for each repeat. Best performing ETTs were then tested in five different cylinder diameters (1.6, 1.8, 2.0, 2.2 and 2.4 cm). Experiments were repeated as above using sterile water. Volume and time taken for aspiration past the cuff was measured. Experiments were repeated (×10) for each type of ETT. Results were analysed using non-parametric tests for repeated measures. Results: The PneuX ETT prevented aspiration past the cuff in all experiments. All other ETTs allowed aspiration, with considerable variability in performance. The PneuX ETT was statistically superior in reducing aspiration compared to the SealGuard (p < 0.009), KimVent (p < 0.002), TaperGuard (p < 0.004), Lanz (p < 0.001), ISIS (p < 0.001), SACETT (p < 0.001) and Soft Seal (p < 0.001) ETTs. Of the 4 ETTs tested in differing cylinder sizes, the PneuX significantly reduced aspiration across the range of diameters compared to the SealGuard (p < 0.0001), TaperGuard (p < 0.0001) and KimVent (p < 0.0001) ETTs. Conclusions: ETTs showed substantial variation in fluid aspiration, relating to cuff material and design. Variability in performance was likely due to the random manner in which involutional folds form in the inflated ETT cuff. The PneuX ETT was the only ETT able to consistently prevent aspiration past the cuff in all experiments.

Citation

Mariyaselvam, M. Z., Marsh, L. L., Bamford, S., Smith, A., Wise, M. P., & Williams, D. W. (2017). Endotracheal tubes and fluid aspiration: An in vitro evaluation of new cuff technologies. BMC Anesthesiology, 17(1), https://doi.org/10.1186/s12871-017-0328-0

Journal Article Type Article
Acceptance Date Feb 20, 2017
Online Publication Date Mar 4, 2017
Publication Date Mar 4, 2017
Deposit Date Oct 2, 2019
Publicly Available Date Oct 4, 2019
Journal BMC Anesthesiology
Electronic ISSN 1471-2253
Publisher BMC
Peer Reviewed Peer Reviewed
Volume 17
Issue 1
DOI https://doi.org/10.1186/s12871-017-0328-0
Public URL https://uwe-repository.worktribe.com/output/3453436
Publisher URL https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-017-0328-0#article-info

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Endotracheal tubes and fluid aspiration: an in vitro evaluation of new cuff technologies (948 Kb)
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Copyright Statement
s This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated





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