Salmonid melanin-concentrating hormone inhibits corticotrophin release

Baker, Bridget I.; Bird, David J.; Buckingham, Julia C.

Abstract

Melanin-concentrating hormone (MCH) is a neural peptide associated with colour change in fishes. We show here that it also inhibits corticotrophin (ACTH) secretion. Synthetic salmonid MCH at a concentration of 100 pmol/l reduced the in-vitro release of ACTH by pars distales (pDs) taken from stressed trout. At lower concentrations (10 pmol/l) the peptide inhibited CRF-41-induced secretion of ACTH by pDs removed from unstressed trout, while at higher concentrations (10 nmol/l) it reduced the corticotrophic response of rat pituitary tissue to CRF-41.

Citation

Baker, B. I., Bird, D. J., & Buckingham, J. C. (1985). Salmonid melanin-concentrating hormone inhibits corticotrophin release. Journal of Endocrinology, 106(2), R5-R8. https://doi.org/10.1677/joe.0.106R005

• Journal Article Type: Article
• Publication Date: Jan 1, 1985
• Journal: Journal of Endocrinology
• Print ISSN: 0022-0795
• Publisher: BioScientifica
• Peer Reviewed: Peer Reviewed
• Volume: 106
• Issue: 2
• Pages: R5-R8
• DOI: https://doi.org/10.1677/joe.0.106R005
• Public URL: https://uwe-repository.worktribe.com/output/1113341
• Publisher URL: http://dx.doi.org/10.1677/joe.0.106R005