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Correlative changes in metabolism and DNA damage in turbot (Scophthalmus maximus) exposed to benzo[a]pyrene

Telli-Karakoç, F; Ruddock, P; Bird, David J.; Hewer, A; Van Schanke, A; Phillips, D.H.; Peters, L.D.

Authors

F Telli-Karakoç

P Ruddock

David J. Bird

A Hewer

A Van Schanke

D.H. Phillips

L.D. Peters



Abstract

Juvenile turbot (Scophthalmus maximus) were injected intraperitonteally with either corn oil or 5 mg/kg benzo[a]pyrene (BaP) dissolved in corn oil and sampled 1 and 3 days after injection. After 1 day, no elevation of 7-ethoxyresorufin O-deethylase (EROD) activity was observed, however bile metabolites (BaP-7,8 dihydrodiol representing 70% of the total metabolites) and a single hepatic DNA adduct spot (0.47 adducts/108 nucleotides) identified by 32P-postlabelling were formed. No BaP metabolites or DNA adducts were observed in either control or carrier control fish. Fish sampled after 3 days reported 5-fold higher (P

Citation

Telli-KarakoƧ, F., Ruddock, P., Bird, D. J., Hewer, A., Van Schanke, A., Phillips, D., & Peters, L. (2002). Correlative changes in metabolism and DNA damage in turbot (Scophthalmus maximus) exposed to benzo[a]pyrene. Marine Environmental Research, 54(3-5), 511-515. https://doi.org/10.1016/S0141-1136%252802%252900192-7

Journal Article Type Article
Publication Date Jan 1, 2002
Journal Marine Environmental Research
Print ISSN 0141-1136
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 54
Issue 3-5
Pages 511-515
DOI https://doi.org/10.1016/S0141-1136%252802%252900192-7
Keywords 7-Ethoxyresorufin O-deethylase activity, benzo[a]pyrene, bile, metabolites, DNA adduct, postlabelling
Publisher URL http://dx.doi.org/10.1016/S0141-1136%2802%2900192-7




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