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Multifunctional zinc finger proteins in development and disease

Ladomery, Michael; Dellaire, G.


G. Dellaire


Post-transcriptional processes contribute significantly towards the generation of proteomic diversity. An increasing number of mutations have been described that affect genes encoding components of the post-transcriptional machinery. In particular, multifunctional proteins that link transcription with post-transcriptional processes have been implicated in several human diseases including cancer. A predominant feature of these proteins is the zinc finger, an ancient structural motif that mediates protein : protein interactions and is capable of interacting with both DNA and RNA. Zinc finger proteins are the most abundant class of proteins in the human proteome, yet the majority remain uncharacterised. Here we describe multifunctional zinc finger proteins linked to human development and disease. The examples discussed are WT1, ZNF74, EWS, TLS, TAFII68, YY1, CTCF and the GLI proteins. The study of these and other zinc finger proteins provides insights into the functional versatility of the zinc finger motif and suggests that both alternative splicing and sub-cellular compartmentalisation may modulate their multifunctionality.


Ladomery, M., & Dellaire, G. (2002). Multifunctional zinc finger proteins in development and disease. Annals of Human Genetics, 66(5-6), 331-342.

Journal Article Type Article
Publication Date Nov 1, 2002
Journal Annals of Human Genetics
Print ISSN 0003-4800
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 66
Issue 5-6
Pages 331-342
Public URL
Publisher URL