Roy W. Jones
A multinational, randomised, 12-week study comparing the effects of donepezil and galantamine in patients with mild to moderate Alzheimer's disease
Jones, Roy W.; Soininen, Hilkka; Hager, Klaus; Aarsland, Dag; Passmore, Peter; Murthy, Anita; Zhang, Richard; Bahra, Ranbir
Authors
Hilkka Soininen
Klaus Hager
Dag Aarsland
Peter Passmore
Anita Murthy
Richard Zhang
Ranbir Bahra
Abstract
Objectives: To compare directly, in the same patient cohort, the ease of use and tolerability of donepezil and galantamine in the treatment of Alzheimer's disease (AD), and investigate the effects of both treatments on cognition and activities of daily living (ADL). Methods: Patients with mild to moderate AD from 14 European centres were randomised to receive open-label donepezil (up to 10 mg once daily) or galantamine (up to 12 mg twice daily) for 12 weeks, according to the approved product labelling. Physicians and caregivers completed questionnaires rating satisfaction with treatment/ease of use in daily practice. Secondary assessments were the ADAS-cog, the MMSE, and the DAD scale to assess ADL. Tolerability was evaluated by reporting adverse events (AEs). Results: Both physicians and caregivers reported significantly greater overall satisfaction/ease of use for donepezil (n = 64) compared with galantamine (n = 56) at weeks 4, 12, and endpoint (week 12 LOCF; all p-values
Citation
Soininen, H., Jones, R. W., Hager, K., Aarsland, D., Passmore, P., Murthy, A., …Bahra, R. (2004). A multinational, randomised, 12-week study comparing the effects of donepezil and galantamine in patients with mild to moderate Alzheimer's disease. International Journal of Geriatric Psychiatry, 19(1), 58-67. https://doi.org/10.1002/gps.1038
| Journal Article Type | Article |
|---|---|
| Publication Date | Jan 1, 2004 |
| Journal | International Journal of Geriatric Psychiatry |
| Print ISSN | 0885-6230 |
| Publisher | Wiley |
| Peer Reviewed | Peer Reviewed |
| Volume | 19 |
| Issue | 1 |
| Pages | 58-67 |
| DOI | https://doi.org/10.1002/gps.1038 |
| Keywords | donepezil, galantamine, Alzheimer's disease, dementia |
| Public URL | https://uwe-repository.worktribe.com/output/1063764 |
| Publisher URL | http://dx.doi.org/10.1002/gps.1038 |