Abnormal spatial and non-spatial cueing effects in mild cognitive impairment and Alzheimer's disease

Haworth, Judy; Tales, Andrea; Haworth, RJ; Snowden, Robert J.; Wilcock, Gordon

Abstract

Our aim was to further characterize the clinical concept of mild cognitive impairment (MCI). We examined visual attention-related processing in 12 patients with amnestic MCI, 16 healthy older adults and 16 patients with Alzheimer's disease (AD) by measuring performance on computer-based tests of attentional disengagement, alerting ability, and inhibition of return. Unlike the healthy older controls, the patients with AD and the patients with amnestic MCI exhibited a significant detriment in both the ability to disengage attention from an incorrectly cued location and the ability to use a visual cue to produce an alerting effect. The pattern of results displayed by the MCI group indicates that patients who only appear clinically to suffer from a deficit in memory also display a deficit in specific aspects of visual attention-related processing, which closely resemble the magnitude seen in AD. Copyright © Taylor & Francis Inc.

• Journal Article Type: Article
• Publication Date: Feb 1, 2005
• Journal: Neurocase
• Print ISSN: 1355-4794
• Electronic ISSN: 1465-3656
• Publisher: Taylor & Francis (Routledge)
• Peer Reviewed: Not Peer Reviewed
• Volume: 11
• Issue: 1
• Pages: 85-92
• DOI: https://doi.org/10.1080/13554790490896983
• Keywords: spatial, non-spatial, cueing effects, mild cognitive impairment, Alzheimer's disease
• Public URL: https://uwe-repository.worktribe.com/output/1051681
• Publisher URL: http://dx.doi.org/10.1080/13554790490896983