Outputs (16)

Exact solutions and equi-dosing regimen regions for multi-dose pharmacokinetics models with transit compartments (2020)
Journal Article
Hof, F., & Bridge, L. J. (2021). Exact solutions and equi-dosing regimen regions for multi-dose pharmacokinetics models with transit compartments. Journal of Pharmacokinetics and Pharmacodynamics, 48, 99-131. https://doi.org/10.1007/s10928-020-09719-8

Compartmental models which yield linear ordinary differential equations (ODEs) provide common tools for pharmacokinetics (PK) analysis, with exact solutions for drug levels or concentrations readily obtainable for low-dimensional compartment models.... Read More about Exact solutions and equi-dosing regimen regions for multi-dose pharmacokinetics models with transit compartments.

Analyzing kinetic signaling data for G-protein-coupled receptors (2020)
Journal Article
Hoare, S. R. J., Tewson, P. H., Quinn, A. M., Hughes, T. E., & Bridge, L. J. (2020). Analyzing kinetic signaling data for G-protein-coupled receptors. Scientific Reports, 10, Article 12263. https://doi.org/10.1038/s41598-020-67844-3

In classical pharmacology, bioassay data are fit to general equations (e.g. the dose response equation) to determine empirical drug parameters (e.g. EC50 and Emax), which are then used to calculate chemical parameters such as affinity and efficacy. H... Read More about Analyzing kinetic signaling data for G-protein-coupled receptors.

A two-state model for the kinetics of competitive radioligand binding (2018)
Journal Article
Guo, D., Peletier, L. A., Bridge, L., Keur, W., de Vries, H., Zweemer, A., …Ijzerman, A. P. (2018). A two-state model for the kinetics of competitive radioligand binding. British Journal of Pharmacology, 175(10), 1719-1730. https://doi.org/10.1111/bph.14184

© 2018 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. Background and Purpose: Ligand–receptor binding kinetics is receiving increasing attention in the drug research co... Read More about A two-state model for the kinetics of competitive radioligand binding.

Ligand binding dynamics for pre-dimerised G protein-coupled receptor homodimers: Linear models and analytical solutions (2018)
Journal Article
White, C., & Bridge, L. (2019). Ligand binding dynamics for pre-dimerised G protein-coupled receptor homodimers: Linear models and analytical solutions. Bulletin of Mathematical Biology, 81(9), 3542-3574. https://doi.org/10.1007/s11538-017-0387-x

Evidence suggests that many G protein-coupled receptors (GPCRs) are bound together forming dimers. The implications of dimerisation for cellular signalling outcomes, and ultimately drug discovery and therapeutics, remain unclear. Consideration of lig... Read More about Ligand binding dynamics for pre-dimerised G protein-coupled receptor homodimers: Linear models and analytical solutions.

Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor (2018)
Journal Article
Bridge, L., Mead, J., Frattini, E., Winfield, I., & Ladds, G. (2018). Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor. Journal of Theoretical Biology, 442, 44-65. https://doi.org/10.1016/j.jtbi.2018.01.010

© 2018 The Authors Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely been... Read More about Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.

Dynamic NF-κb and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation (2016)
Journal Article
Harper, C. V., Adamson, A. D., White, M. R., Jones, N. A., Jackson, D. A., Ankers, J. M., …White, M. R. (2016). Dynamic NF-κb and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation. eLife, 5(MAY2016), https://doi.org/10.7554/eLife.10473

© Ankers et al. Dynamic cellular systems reprogram gene expression to ensure appropriate cellular fate responses to specific extracellular cues. Here we demonstrate that the dynamics of Nuclear Factor kappa B (NF-κB) signalling and the cell cycle are... Read More about Dynamic NF-κb and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation.

A method of ‘speed coefficients’ for biochemical model reduction applied to the NF-κB system (2014)
Journal Article
West, S., Bridge, L. J., White, M. R. H., Paszek, P., & Biktashev, V. N. (2015). A method of ‘speed coefficients’ for biochemical model reduction applied to the NF-κB system. Journal of Mathematical Biology, 70(3), 591-620. https://doi.org/10.1007/s00285-014-0775-x

© 2014, The Author(s). The relationship between components of biochemical network and the resulting dynamics of the overall system is a key focus of computational biology. However, as these networks and resulting mathematical models are inherently co... Read More about A method of ‘speed coefficients’ for biochemical model reduction applied to the NF-κB system.

Impact of plant shoot architecture on leaf cooling: A coupled heat and mass transfer model (2013)
Journal Article
Bridge, L. J., Bridge, L., Franklin, K. A., & Homer, M. E. (2013). Impact of plant shoot architecture on leaf cooling: A coupled heat and mass transfer model. Interface, 10(85), 20130326. https://doi.org/10.1098/rsif.2013.0326

Plants display a range of striking architectural adaptations when grown at elevated temperatures. In the model plant Arabidopsis thaliana, these include elongation of petioles, and increased petiole and leaf angles from the soil surface. The potentia... Read More about Impact of plant shoot architecture on leaf cooling: A coupled heat and mass transfer model.

Distinguishing possible mechanisms for auxin-mediated developmental control in Arabidopsis: Models with two Aux/IAA and ARF proteins, and two target gene-sets (2012)
Journal Article
Bridge, L., Mirams, G. R., Kieffer, M. L., King, J. R., & Kepinski, S. (2012). Distinguishing possible mechanisms for auxin-mediated developmental control in Arabidopsis: Models with two Aux/IAA and ARF proteins, and two target gene-sets. Mathematical Biosciences, 235(1), 32-44. https://doi.org/10.1016/j.mbs.2011.10.005

New models of gene transcriptional responses to auxin signalling in Arabidopsis are presented. This work extends a previous model of auxin signalling to include networks of gene-sets which may control developmental responses along auxin gradients. Ke... Read More about Distinguishing possible mechanisms for auxin-mediated developmental control in Arabidopsis: Models with two Aux/IAA and ARF proteins, and two target gene-sets.

Allosteric interactions across native adenosine-A 3 receptor homodimers: Quantification using single-cell ligand-binding kinetics (2011)
Journal Article
May, L. T., Bridge, L., Stoddart, L. A., Briddon, S. J., & Hill, S. J. (2011). Allosteric interactions across native adenosine-A 3 receptor homodimers: Quantification using single-cell ligand-binding kinetics. FASEB Journal, 25(10), 3465-3476. https://doi.org/10.1096/fj.11-186296

A growing awareness indicates that many G-protein-coupled receptors (GPCRs) exist as homodimers, but the extent of the cooperativity across the dimer interface has been largely unexplored. Here, measurement of the dissociation kinetics of a fluoresce... Read More about Allosteric interactions across native adenosine-A 3 receptor homodimers: Quantification using single-cell ligand-binding kinetics.