Outputs (10)

Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort (2023)
Journal Article
Lussier, A. A., Zhu, Y., Smith, B. J., Cerutti, J., Fisher, J., Melton, P., …Dunn, E. C. (2023). Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort. Lancet Child and Adolescent Health, 7(8), 532-543. https://doi.org/10.1016/S2352-4642%2823%2900127-X

Background: Childhood adversity is a potent determinant of health across development and is associated with altered DNA methylation signatures, which might be more common in children exposed during sensitive periods in development. However, it remain... Read More about Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort.

Home and epigenome: How DNA methylation could explain the association between housing quality and depression (2023)
Journal Article
Sanders, F., Baltramonaityte, V., Alexander, L., Smith, A., Dunn, E., & Walton, E. (2023). Home and epigenome: How DNA methylation could explain the association between housing quality and depression. Neuroscience Applied, 2(Supplement 1), Article 101111. https://doi.org/10.1016/j.nsa.2023.101111

Poor housing quality is a consistent risk factor for mental health problems. Despite the large body of evidence for housing’s relationship with mental health, housing quality as an environmental stressor has not yet been investigated with regards to... Read More about Home and epigenome: How DNA methylation could explain the association between housing quality and depression.

Sensitive periods for the effect of child maltreatment on psychopathology symptoms in adolescence (2023)
Journal Article
Dunn, E. C., Busso, D. S., Davis, K. A., Smith, A. D. A. C., Mitchell, C., Tiemeier, H., & Susser, E. S. (2023). Sensitive periods for the effect of child maltreatment on psychopathology symptoms in adolescence. Complex Psychiatry, 9(1-4), 145-153. https://doi.org/10.1159/000530120

Introduction: Child maltreatment is among the strongest risk factors for mental disorders. However, little is known about whether there are ages when children may be especially vulnerable to its effects. We sought to identify potential sensitive peri... Read More about Sensitive periods for the effect of child maltreatment on psychopathology symptoms in adolescence.

Testing lifecourse theories characterising associations between maternal depression and offspring depression in emerging adulthood: The Avon Longitudinal Study of Parents and Children (2022)
Journal Article
Lacey, R. E., Gondek, D., Smith, B. J., Smith, A. D., Dunn, E. C., & Sacker, A. (2023). Testing lifecourse theories characterising associations between maternal depression and offspring depression in emerging adulthood: The Avon Longitudinal Study of Parents and Children. Journal of Child Psychology and Psychiatry, 64(8), 1149-1158. https://doi.org/10.1111/jcpp.13699

Background: Maternal depression is a major determinant of offspring mental health. Yet, little is understood about how the duration and timing of maternal depression shapes youth risk for depressive symptoms, which if understood could inform when bes... Read More about Testing lifecourse theories characterising associations between maternal depression and offspring depression in emerging adulthood: The Avon Longitudinal Study of Parents and Children.

Socioeconomic changes predict genome-wide DNA methylation in childhood (2022)
Journal Article
Liu, J., Cerutti, J., Lussier, A. A., Zhu, Y., Smith, B. J., Smith, A. D. A. C., & Dunn, E. C. (2023). Socioeconomic changes predict genome-wide DNA methylation in childhood. Human Molecular Genetics, 32(5), 709-719. https://doi.org/10.1093/hmg/ddac171

Childhood socioeconomic position (SEP) is a major determinant of health and well-being across the entire life course. To effectively prevent and reduce health risks related to SEP, it is critical to better understand when and under what circumstances... Read More about Socioeconomic changes predict genome-wide DNA methylation in childhood.

Examining the epigenetic mechanisms of childhood adversity and sensitive periods: A gene set-based approach (2022)
Journal Article
Zhu, Y., Lussier, A. A., Smith, A. D. A. C., Simpkin, A. J., Suderman, M. J., Walton, E., …Dunn, E. C. (2022). Examining the epigenetic mechanisms of childhood adversity and sensitive periods: A gene set-based approach. Psychoneuroendocrinology, 144(October 2022), 105854. https://doi.org/10.1016/j.psyneuen.2022.105854

Background: Sensitive periods are developmental stages of heightened plasticity when life experiences, including exposure to childhood adversity, have the potential to exert more lasting impacts. Epigenetic mechanisms, including DNA methylation (DNAm... Read More about Examining the epigenetic mechanisms of childhood adversity and sensitive periods: A gene set-based approach.

Sensitive periods for the effect of childhood adversity on DNA methylation: Updated results from a prospective, longitudinal study (2022)
Journal Article
Lussier, A. A., Zhu, Y., Smith, B. J., Simpkin, A. J., Smith, A. D. A. C., Suderman, M. J., …Dunn, E. C. (2023). Sensitive periods for the effect of childhood adversity on DNA methylation: Updated results from a prospective, longitudinal study. Biological Psychiatry: Global Open Science, 3(3), 567-571. https://doi.org/10.1016/j.bpsgos.2022.04.002

Statistical modeling of sensitive period effects using the structured life course modelling approach (SLCMA) (2022)
Book Chapter
Smith, B. J., Smith, A. D., & Dunn, E. C. (2022). Statistical modeling of sensitive period effects using the structured life course modelling approach (SLCMA). In Sensitive Periods of Brain Development and Preventive Interventions (215-234). Springer. https://doi.org/10.1007/7854_2021_280

Sensitive periods are times during development when life experiences can have a greater impact on outcomes than at other periods during the life course. However, a dearth of sophisticated methods for studying time-dependent exposure-outcome relations... Read More about Statistical modeling of sensitive period effects using the structured life course modelling approach (SLCMA).

Association between measures derived from children's primary exfoliated teeth and psychopathology symptoms: Results from a community-based study (2022)
Journal Article
Dunn, E. C., Mountain, R. V., Davis, K. A., Shaffer, I., Smith, A. D. A. C., Roubinov, D. S., …Boyce, W. T. (2022). Association between measures derived from children's primary exfoliated teeth and psychopathology symptoms: Results from a community-based study. Frontiers in Dental Medicine, 3, Article 803364. https://doi.org/10.3389/fdmed.2022.803364

Mental disorders are among the most disabling health conditions globally. However, there remains a lack of valid, reliable, noninvasive, and inexpensive biomarkers to identify (at an early age) people who are at the greatest risk of experiencing a fu... Read More about Association between measures derived from children's primary exfoliated teeth and psychopathology symptoms: Results from a community-based study.

Updates to data versions and analytic methods influence the reproducibility of results from epigenome-wide association studies (2022)
Journal Article
Lussier, A. A., Zhu, Y., Smith, B. J., Simpkin, A. J., Smith, A. D., Suderman, M. J., …Dunn, E. C. (2022). Updates to data versions and analytic methods influence the reproducibility of results from epigenome-wide association studies. Epigenetics, https://doi.org/10.1080/15592294.2022.2028072

Introduction: Biomedical research has grown increasingly cooperative through the sharing of consortia-level epigenetic data. Since consortia preprocess data prior to distribution, new processing pipelines can lead to different versions of the same d... Read More about Updates to data versions and analytic methods influence the reproducibility of results from epigenome-wide association studies.