Dr Andrew Smith's Outputs (29)

2008 financial crisis versus 2020 economic fallout: How COVID-19 might influence fertility treatment and live births (2021)
Journal Article

Research question
The economic and reproductive medicine response to the coronavirus disease 2019 (COVID-19) pandemic in the USA has reduced the affordability and accessibility of fertility care. What is the impact of the 2008 financial recession an... Read More about 2008 financial crisis versus 2020 economic fallout: How COVID-19 might influence fertility treatment and live births.

A structured approach to evaluating life course hypotheses: Moving beyond analyses of exposed versus unexposed in the omics context (2020)
Journal Article

The structured life course modeling approach (SLCMA) is a theory-driven analytic method that empirically compares multiple prespecified life course hypotheses characterizing time-dependent exposure-outcome relationships to determine which theory best... Read More about A structured approach to evaluating life course hypotheses: Moving beyond analyses of exposed versus unexposed in the omics context.

Exposure to early childhood maltreatment and its effect over time on social cognition (2020)
Journal Article

Social cognitive deficits can have many negative consequences, spanning social withdrawal to psychopathology. Prior work has shown that child maltreatment may associate with poorer social cognitive skills in later life. However, no studies have exami... Read More about Exposure to early childhood maltreatment and its effect over time on social cognition.

The mental health effects of pet death during childhood: Is it better to have loved and lost than never to have loved at all? (2020)
Journal Article

Pet ownership is common. Growing evidence suggests children form deep emotional attachments to their pets. Yet, little is known about children’s emotional reactions to a pet’s death. The goal of this study was to describe the relationship between exp... Read More about The mental health effects of pet death during childhood: Is it better to have loved and lost than never to have loved at all?.

Population implications of cessation of IVF during the COVID-19 pandemic (2020)
Journal Article

Research question: Discontinuation of IVF cycles has been part of the radical transformation of healthcare provision to enable reallocation of staff and resources to deal with the COVID-19 pandemic. This study sought to estimate the impact of cessati... Read More about Population implications of cessation of IVF during the COVID-19 pandemic.

Live birth rates and perinatal outcomes when all embryos are frozen compared with conventional fresh and frozen embryo transfer: a cohort study of 337,148 in vitro fertilisation cycles (2019)
Journal Article

BACKGROUND: It is not known whether segmentation of an in vitro fertilisation (IVF) cycle, with freezing of all embryos prior to transfer, increases the chance of a live birth after all embryos are transferred. METHODS: In a prospective study of UK H... Read More about Live birth rates and perinatal outcomes when all embryos are frozen compared with conventional fresh and frozen embryo transfer: a cohort study of 337,148 in vitro fertilisation cycles.

Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children (2019)
Journal Article

Objectives: Exposure to adversity has been linked to accelerated biological aging, which in turn has been shown to predict numerous physical and mental health problems. In recent years, measures of DNA methylation-based epigenetic age––known as “epig... Read More about Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children.

Sensitive periods for the effect of childhood adversity on DNA methylation: Results from a prospective, longitudinal study (2019)
Journal Article

Background: Exposure to "early life" adversity is known to predict DNA methylation (DNAm) patterns that may be related to psychiatric risk. However, few studies have investigated whether adversity has time-dependent effects based on the age at exposu... Read More about Sensitive periods for the effect of childhood adversity on DNA methylation: Results from a prospective, longitudinal study.

Exposure to childhood adversity and deficits in emotion recognition: results from a large, population-based sample (2018)
Journal Article

© 2018 Association for Child and Adolescent Mental Health. Background: Emotion recognition skills are essential for social communication. Deficits in these skills have been implicated in mental disorders. Prior studies of clinical and high-risk sampl... Read More about Exposure to childhood adversity and deficits in emotion recognition: results from a large, population-based sample.

What life course theoretical models best explain the relationship between exposure to childhood adversity and psychopathology symptoms: Recency, accumulation, or sensitive periods? (2018)
Journal Article

Copyright © Cambridge University Press 2018Â. Background Although childhood adversity is a potent determinant of psychopathology, relatively little is known about how the characteristics of adversity exposure, including its developmental timing or du... Read More about What life course theoretical models best explain the relationship between exposure to childhood adversity and psychopathology symptoms: Recency, accumulation, or sensitive periods?.

Maternal dietary patterns during pregnancy and intelligence quotients in the offspring at 8years of age: Findings from the ALSPAC cohort (2017)
Journal Article

© 2017 The Authors. Maternal & Child Nutrition Published by John Wiley & Sons Ltd Dietary intake during pregnancy may influence child neurodevelopment and cognitive function. This study aims to investigate the associations between dietary pattern... Read More about Maternal dietary patterns during pregnancy and intelligence quotients in the offspring at 8years of age: Findings from the ALSPAC cohort.

Programming of adiposity in childhood and adolescence: Associations with birth weight and cord blood adipokines (2017)
Journal Article

© 2017 by the Endocrine Society. Context: Exposure to maternal adiposity during pregnancy is associated with higher offspring birth weight and greater adiposity through childhood and adult life. As birth weight reflects the summation of lean and fat... Read More about Programming of adiposity in childhood and adolescence: Associations with birth weight and cord blood adipokines.

Joint modelling compared with two stage methods for analysing longitudinal data and prospective outcomes: A simulation study of childhood growth and BP (2017)
Journal Article

© The Author(s) 2014. There is a growing debate with regards to the appropriate methods of analysis of growth trajectories and their association with prospective dependent outcomes. Using the example of childhood growth and adult BP, we conducted an... Read More about Joint modelling compared with two stage methods for analysing longitudinal data and prospective outcomes: A simulation study of childhood growth and BP.

Dietary patterns by cluster analysis in pregnant women: relationship with nutrient intakes and dietary patterns in 7-year-old offspring (2016)
Journal Article

© 2016 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd. Little is known about how dietary patterns of mothers and their children track over time. The objectives of this study are to obtain dietary patterns in pregnancy... Read More about Dietary patterns by cluster analysis in pregnant women: relationship with nutrient intakes and dietary patterns in 7-year-old offspring.

Cord blood adipokines and lipids and adolescent nonalcoholic fatty liver disease (2016)
Journal Article

© 2016 by the Endocrine Society. Context: Maternal adiposity in pregnancy is associated with offspring adiposity and metabolic dysfunction postnatally, including greater risk of nonalcoholic fatty liver disease (NAFLD). Recent genetic analyses sugges... Read More about Cord blood adipokines and lipids and adolescent nonalcoholic fatty liver disease.

A structured approach to hypotheses involving continuous exposures over the life course (2016)
Journal Article

© The Author 2016. Published by Oxford University Press on behalf of the International Epidemiological Association. Background: Epidemiologists are often interested in examining different hypotheses for how exposures measured repeatedly over the life... Read More about A structured approach to hypotheses involving continuous exposures over the life course.

Relationship between mediation analysis and the structured life course approach (2016)
Journal Article

© The Author 2016. Published by Oxford University Press on behalf of the International Epidemiological Association. Many questions in life course epidemiology involve mediation and/or interaction because of the long latency period between exposures a... Read More about Relationship between mediation analysis and the structured life course approach.

Live-birth rate associated with repeat in vitro fertilization treatment cycles (2015)
Journal Article

© 2015 American Medical Association. All rights reserved. Importance The likelihood of achieving a live birth with repeat in vitro fertilization (IVF) is unclear, yet treatment is commonly limited to 3 or 4 embryo transfers. Objective To determine th... Read More about Live-birth rate associated with repeat in vitro fertilization treatment cycles.

Model selection of the effect of binary exposures over the life course (Epidemiology (2015) 26 (719-726)) (2015)
Journal Article

Epidemiologists are often interested in examining the effect on a later-life outcome of an exposure measured repeatedly over the life course. When different hypotheses for this effect are proposed by competing theories, it is important to identify th... Read More about Model selection of the effect of binary exposures over the life course (Epidemiology (2015) 26 (719-726)).

External validation and calibration of IVFpredict:A national prospective cohort study of 130,960 in vitro fertilisation Cycles (2015)
Journal Article

© 2015 Smith et al. Background Accurately predicting the probability of a live birth after in vitro fertilisation (IVF) is important for patients, healthcare providers and policy makers. Two prediction models (Templeton and IVFpredict) have been prev... Read More about External validation and calibration of IVFpredict:A national prospective cohort study of 130,960 in vitro fertilisation Cycles.