Katherine Williams
Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis
Williams, Katherine; Szwalbe, Agnieszka J; Dickson, Claire; Desson, Tim R; Mulholland, Nicholas P; Vincent, Jason L; Clough, John M; Bailey, Andrew M; Butts, Craig P; Willis, Christine L; Simpson, Thomas J; Cox, Russell J
Authors
Agnieszka J Szwalbe
Claire Dickson
Tim R Desson
Nicholas P Mulholland
Jason L Vincent
John M Clough
Andrew M Bailey
Craig P Butts
Christine L Willis
Thomas J Simpson
Russell J Cox
Abstract
The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.
Citation
Williams, K., Szwalbe, A. J., Dickson, C., Desson, T. R., Mulholland, N. P., Vincent, J. L., …Cox, R. J. (2017). Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis. Chemical Communications, 53(56), 7965-7968. https://doi.org/10.1039/c7cc03303f
Journal Article Type | Article |
---|---|
Online Publication Date | Jun 23, 2017 |
Publication Date | Jun 23, 2017 |
Deposit Date | Apr 11, 2024 |
Publicly Available Date | Apr 12, 2024 |
Journal | Chemical Communications |
Print ISSN | 1359-7345 |
Electronic ISSN | 1364-548X |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Volume | 53 |
Issue | 56 |
Pages | 7965-7968 |
DOI | https://doi.org/10.1039/c7cc03303f |
Public URL | https://uwe-repository.worktribe.com/output/11881312 |
Publisher URL | http://dx.doi.org/10.1039/c7cc03303f |
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Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis
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Copyright Statement
This is the author's accepted manuscript. The final published version is available here: https://doi.org/10.1039/c7cc03303f
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