@article { , title = {An electrocatalytic screen-printed amperometric sensor for the selective measurement of thiamine (Vitamin B1) in food supplements}, abstract = {An electrocatalytic screen-printed sensor has been investigated for the measurement of the biologically important biomolecule vitamin B1 (thiamine) for the first time in food supplements. Under basic conditions, the vitamin was converted to its electrochemically active thiolate anion species. It was shown that an electrocatalytic oxidation reaction occurred with the screen-printed carbon electrode containing the mediator cobalt phthalocyanine (CoPC-SPCE). This had the advantage of producing an analytical response current at an operating potential of 0 V vs. Ag/AgCl compared to +0.34 V obtained with plain SPCEs. This resulted in improved selectivity and limit of detection. Detailed studies on the underlying mechanism occurring with the sensor are reported in this paper. A linear response was obtained between 0.1 and 20 µg mL −1 , which was suitable for the quantification of the vitamin in two commercial products containing vitamin B1. The mean recovery for a multivitamin tablet with a declared content of 5 mg was 101\% (coefficient of variation (CV) of 9.6\%). A multivitamin drink, which had a much lower concentration of vitamin B1 (0.22 mg/100 mL), gave a mean recovery of 93.3\% (CV 7.2\%). These results indicate that our sensor holds promise for quality control of food supplements and other food types.}, doi = {10.3390/bios9030098}, eissn = {2079-6374}, issue = {3}, journal = {Biosensors}, note = {Received: 11 July 2019; Accepted: 2 August 2019; Published: 6 August 2019 check for updates; biosensors Article}, publicationstatus = {Published}, publisher = {MDPI}, url = {https://uwe-repository.worktribe.com/output/2314795}, volume = {9}, keyword = {Centre for Research in Biosciences, cobalt phthalocyanine, screen-printed carbon electrode, cyclic voltammetry, amperometry, thiamine, food supplements}, year = {2019}, author = {Smart, Amy and Westmacott, Kelly L. and Crew, Adrian and Doran, Olena and Hart, John P.} }