@article { , title = {Correlative changes in metabolism and DNA damage in turbot (Scophthalmus maximus) exposed to benzo[a]pyrene}, abstract = {Juvenile turbot (Scophthalmus maximus) were injected intraperitonteally with either corn oil or 5 mg/kg benzo[a]pyrene (BaP) dissolved in corn oil and sampled 1 and 3 days after injection. After 1 day, no elevation of 7-ethoxyresorufin O-deethylase (EROD) activity was observed, however bile metabolites (BaP-7,8 dihydrodiol representing 70\% of the total metabolites) and a single hepatic DNA adduct spot (0.47 adducts/108 nucleotides) identified by 32P-postlabelling were formed. No BaP metabolites or DNA adducts were observed in either control or carrier control fish. Fish sampled after 3 days reported 5-fold higher (P}, doi = {10.1016/S0141-1136\%2802\%2900192-7}, issn = {0141-1136}, issue = {3-5}, journal = {Marine Environmental Research}, pages = {511-515}, publicationstatus = {Published}, publisher = {Elsevier}, url = {https://uwe-repository.worktribe.com/output/1084170}, volume = {54}, keyword = {Centre for Research in Biosciences, 7-Ethoxyresorufin O-deethylase activity, benzo[a]pyrene, bile, metabolites, DNA adduct, postlabelling}, year = {2002}, author = {Telli-Karakoç, F and Ruddock, P and Bird, David J. and Hewer, A and Van Schanke, A and Phillips, D.H. and Peters, L.D.} }