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The OdonAssist inflatable device for assisted vaginal birth—the ASSIST II study (United Kingdom) (2023)
Journal Article
Hotton, E. J., Hotton, E. J., Bale, N., Rose, C., White, P., Wade, J., …Reading, I. (2024). The OdonAssist inflatable device for assisted vaginal birth—the ASSIST II study (United Kingdom). American Journal of Obstetrics and Gynecology, 230(3), https://doi.org/10.1016/j.ajog.2023.05.018

Background: Decreasing rates of assisted vaginal birth have been paralleled with increasing rates of cesarean deliveries over the last 40 years. The OdonAssist is a novel device for assisted vaginal birth. Iterative changes to clinical parameters, de... Read More about The OdonAssist inflatable device for assisted vaginal birth—the ASSIST II study (United Kingdom).

A prospective comparison of invasive and non‐invasive blood pressure in children undergoing cardiac catheterization (2023)
Journal Article
Beringer, R., Keith, A., Jones, E., Murphy, T., & White, P. (in press). A prospective comparison of invasive and non‐invasive blood pressure in children undergoing cardiac catheterization. Pediatric Anesthesia, 33(10), 816-822. https://doi.org/10.1111/pan.14723

Background: Blood pressure measurement is a standard of monitoring during general anesthesia. Invasive measurement is considered the gold standard but is less commonly used than non-invasive. Automated oscillometric blood pressure devices measure the... Read More about A prospective comparison of invasive and non‐invasive blood pressure in children undergoing cardiac catheterization.

Early intravenous beta-blockade with esmolol in adults with severe traumatic brain injury (EBB-TBI): Protocol for a phase 2a intervention design study (2023)
Journal Article
Thomas, M., Hayes, K., White, P., Ramesh, A., Culliford, L., Ackland, G., & Pickering, A. (2024). Early intravenous beta-blockade with esmolol in adults with severe traumatic brain injury (EBB-TBI): Protocol for a phase 2a intervention design study. Neurocritical Care, 40, 795–806. https://doi.org/10.1007/s12028-023-01755-9

Traumatic brain injury is a leading cause of death and disability worldwide. Interventions that mitigate secondary brain injury have the potential to improve outcomes for patients and reduce the impact on communities and society. Increased circulatin... Read More about Early intravenous beta-blockade with esmolol in adults with severe traumatic brain injury (EBB-TBI): Protocol for a phase 2a intervention design study.

Sensory training system for use at home by people with complex regional pain syndrome in England: Protocol for a proof-of-concept study (2023)
Journal Article
Coggins, J., Grieve, S., Hart, D., Llewellyn, A., Palmer, M., Boichat, C., & McCabe, C. (2023). Sensory training system for use at home by people with complex regional pain syndrome in England: Protocol for a proof-of-concept study. BMJ Open, 13(5), Article e070920. https://doi.org/10.1136/bmjopen-2022-070920

INTRODUCTION: Complex regional pain syndrome (CRPS) is a disabling and distressing chronic pain condition characterised by a range of sensory, motor, autonomic and trophic symptoms. UK guidelines recommend therapy interventions to help normalise touc... Read More about Sensory training system for use at home by people with complex regional pain syndrome in England: Protocol for a proof-of-concept study.

The just-about-right pilot sample size to control the error margin (2023)
Journal Article
Obodo, S., Toher, D., & White, P. (2023). The just-about-right pilot sample size to control the error margin. International Journal of Statistics and Probability, 12(3), https://doi.org/10.5539/ijsp.v12n3p1

In practice, the required sample size for a two-arm randomised controlled trial cannot always be determined pre-study with great accuracy. This lack of accuracy has economic, ethical and scientific implications. The sample size for a pilot study is... Read More about The just-about-right pilot sample size to control the error margin.

Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients (2023)
Journal Article
Harland, A. J., Perks, C. M., White, P., Kurian, K. M., & Barber, H. R. (2023). Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients. Cancer Medicine, 12(13), 14426-14439. https://doi.org/10.1002/cam4.6071

Background: The overall survival of IDH-wildtype glioblastoma patients is poor despite best available treatments. There is an urgent need for new biomarkers to inform more precise disease stratification. Previous studies have identified insulin-like... Read More about Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients.

Outcomes from a community speech and language therapy service treatment waiting list: The natural history of 525 children with identified speech and language needs (2023)
Journal Article
Hesketh, E., White, P., Simkiss, D., & Roulstone, S. (2023). Outcomes from a community speech and language therapy service treatment waiting list: The natural history of 525 children with identified speech and language needs. International Journal of Language and Communication Disorders, 58(5), 1510-1525. https://doi.org/10.1111/1460-6984.12877

Abstract Background Understanding the natural history of developmental speech and language impairments can support the selection of children whose difficulties are persistent rather than transitory. It can also provide information against which... Read More about Outcomes from a community speech and language therapy service treatment waiting list: The natural history of 525 children with identified speech and language needs.

The effect of isocaloric, energy-restrictive, KETOgenic diet on metabolism, inflammation, nutrition deficiencies and oxidative stress in women with overweight and obesity (KETO-MINOX): Study protocol (2023)
Journal Article
Drabinska, N., Romaszko, J., & White, P. (2023). The effect of isocaloric, energy-restrictive, KETOgenic diet on metabolism, inflammation, nutrition deficiencies and oxidative stress in women with overweight and obesity (KETO-MINOX): Study protocol. PLoS ONE, 18(5), Article e0285283. https://doi.org/10.1371/journal.pone.0285283

Obesity is considered one of the biggest health problems of the 21st century, becoming a worldwide epidemic, leading to the development of many diseases and increasing the risk of premature death. The first step in reducing body weight is a calorie-r... Read More about The effect of isocaloric, energy-restrictive, KETOgenic diet on metabolism, inflammation, nutrition deficiencies and oxidative stress in women with overweight and obesity (KETO-MINOX): Study protocol.

The randomised thoracoscopic talc poudrage+indwelling pleural catheters versus thoracoscopic talc poudrage only in malignant pleural effusion trial (TACTIC): Study protocol for a randomised controlled trial (2023)
Journal Article
Sundaralingam, A., Hedley, E., Tucker, E., White, P., Bhatnagar, R., Moore, A., …Maskell, N. A. (2023). The randomised thoracoscopic talc poudrage+indwelling pleural catheters versus thoracoscopic talc poudrage only in malignant pleural effusion trial (TACTIC): Study protocol for a randomised controlled trial. BMJ Open Respiratory Research, 10(1), e001682. https://doi.org/10.1136/bmjresp-2023-001682

INTRODUCTION: Malignant pleural effusion (MPE) is common, with 50 000 new cases per year in the UK. MPE causes disabling breathlessness and indicates advanced disease with a poor prognosis. Treatment approaches focus on symptom relief and optimising... Read More about The randomised thoracoscopic talc poudrage+indwelling pleural catheters versus thoracoscopic talc poudrage only in malignant pleural effusion trial (TACTIC): Study protocol for a randomised controlled trial.

NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model (2023)
Journal Article
Grätz, L., Sajkowska-Kozielewicz, J. J., Wesslowski, J., Kinsolving, J., Bridge, L. J., Petzold, K., …Kozielewicz, P. (in press). NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model. British Journal of Pharmacology, https://doi.org/10.1111/bph.16090

Background and Purpose: Wnt binding to Frizzleds (FZD) is a crucial step that leads to the initiation of signalling cascades governing multiple processes during embryonic development, stem cell regulation and adult tissue homeostasis. Recent efforts... Read More about NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model.

Impact of procedure type on revisional surgery and secondary reconstruction after immediate breast reconstruction in a population-based cohort (2023)
Journal Article
Johnson, L., White, P., Holcombe, C., O’Donoghue, J., Jeevan, R., Browne, J., …O'Donoghue, J. (2023). Impact of procedure type on revisional surgery and secondary reconstruction after immediate breast reconstruction in a population-based cohort. British Journal of Surgery, 110(6), 666-675. https://doi.org/10.1093/bjs/znad050

Background: Women considering immediate breast reconstruction require high-quality information about the likely need for secondary reconstruction and the long-term risk of revisional surgery to make fully informed decisions about different reconstruc... Read More about Impact of procedure type on revisional surgery and secondary reconstruction after immediate breast reconstruction in a population-based cohort.

Use of illness severity scores to predict mortality in interstitial lung disease patients hospitalised with acute respiratory deterioration (2023)
Journal Article
Williams, R. L., Hyams, C., Robertshaw, J., Garcia Gonzalez, M., Szasz-Benczur, Z., White, P., … Barratt, S. L. (2023). Use of illness severity scores to predict mortality in interstitial lung disease patients hospitalised with acute respiratory deterioration. Respiratory Medicine, 212, 107220. https://doi.org/10.1016/j.rmed.2023.107220

Introduction: Hospitalisations relating to acute respiratory deteriorations (ARD) in Interstitial Lung Disease (ILD) have poor outcomes. Factors predicting adverse outcomes are not fully understood and data addressing the use of illness severity scor... Read More about Use of illness severity scores to predict mortality in interstitial lung disease patients hospitalised with acute respiratory deterioration.

Responsive fungal insoles for pressure detection (2023)
Journal Article
Nikolaidou, A., Phillips, N., Tsompanas, M. A., & Adamatzky, A. (2023). Responsive fungal insoles for pressure detection. Scientific Reports, 13(1), 4595. https://doi.org/10.1038/s41598-023-31594-9

Mycelium bound composites are promising materials for a diverse range of applications including wearables and building elements. Their functionality surpasses some of the capabilities of traditionally passive materials, such as synthetic fibres, reco... Read More about Responsive fungal insoles for pressure detection.

The Bristol Bladder Trial: Five year outcomes in patients treated with neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder (2023)
Journal Article
Challapalli, A., White, P., Masson, S., Foulstone, E., Renninson, E., Bravo, A., …Bahl, A. (2023). The Bristol Bladder Trial: Five year outcomes in patients treated with neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder. Journal of Clinical Oncology, 41(6_suppl), 493-493. https://doi.org/10.1200/JCO.2023.41.6_suppl.493

Background: Neoadjuvant cisplatin-based combination chemotherapy (NAC) improves survival in muscle invasive bladder cancer (MIBC). However, response rates and survival remain suboptimal. We sought to evaluate the efficacy of cabazitaxel with cisplati... Read More about The Bristol Bladder Trial: Five year outcomes in patients treated with neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder.

Real world prospective evaluation of clinical outcomes in patients with non-metastatic castrate resistant prostate cancer treated with darolutamide (2023)
Journal Article
Challapali, A., Rennison, E., White, P., Elumalai, T., Parikh, O., Vickers, A., …Bahl, A. (2023). Real world prospective evaluation of clinical outcomes in patients with non-metastatic castrate resistant prostate cancer treated with darolutamide. Journal of Clinical Oncology, 41(6_suppl), 335. https://doi.org/10.1200/JCO.2023.41.6_suppl.335

Background: The RECORD Study is a real world data, prospective evaluation of clinical outcomes in patients with nmCRPC treated with Darolutamide. This study will increase the understanding of treatment response and management and in particular inform... Read More about Real world prospective evaluation of clinical outcomes in patients with non-metastatic castrate resistant prostate cancer treated with darolutamide.

Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins (2022)
Journal Article
Maqsood, Z., Clark, J. C., Martin, E. M., Cheung, Y. F. H., Morán, L. A., Watson, S. E. T., …Watson, S. P. (2022). Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins. PLoS Computational Biology, 18(11), Article e1010708. https://doi.org/10.1371/journal.pcbi.1010708

The clustering of platelet glycoprotein receptors with cytosolic YxxL and YxxM motifs, including GPVI, CLEC-2 and PEAR1, triggers activation via phosphorylation of the conserved tyrosine residues and recruitment of the tandem SH2 (Src homology 2) dom... Read More about Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins.

BRIVEST: A ‘real-world’ observational, single-centre study investigating the efficacy, safety and tolerability of Brivaracetam (2022)
Journal Article
Naddell, S., Manuel, M., Cavill, R., White, P., & Sieradzan, K. (2023). BRIVEST: A ‘real-world’ observational, single-centre study investigating the efficacy, safety and tolerability of Brivaracetam. Epilepsy and Behavior, 138, 108985. https://doi.org/10.1016/j.yebeh.2022.108985

Objective: Via measures of efficacy, tolerability, and safety, this open-label, single-center study assessed the overall effectiveness of Brivaracetam (BRV) for the treatment of epilepsy in the context of ‘real-world’ clinical practice. Methods: Unse... Read More about BRIVEST: A ‘real-world’ observational, single-centre study investigating the efficacy, safety and tolerability of Brivaracetam.

Rethinking living matter: Animate behaviours of fungal composites (2022)
Presentation / Conference
Nikolaidou, A., & Adamatzky, A. (2022, September). Rethinking living matter: Animate behaviours of fungal composites. Paper presented at SEEDS International Conference 2022, University of West of England, Bristol

Smart materials integrating conventional soft electronics e.g. sensors and actuators, are widely used in the building and wearable industries, contributing to the depletion of natural resources and having a vast environmental impact. In this paper, a... Read More about Rethinking living matter: Animate behaviours of fungal composites.

Acceptability of Lycra arm sleeve in people with sub-acute stroke: Patients', carers' and clinicians' perspectives (2022)
Journal Article
Kumar, P., Jones, R., Cramp, M., Greenwood, R., White, P., & Turton, A. (2023). Acceptability of Lycra arm sleeve in people with sub-acute stroke: Patients', carers' and clinicians' perspectives. Physiotherapy, 118, 31-38. https://doi.org/10.1016/j.physio.2022.08.002

Background: Previous studies found that the Lycra sleeve has potential to reduce glenohumeral subluxation in people with stroke. The primary aim of this study was to explore the acceptability of the Lycra sleeve from patients’, carers’ and staff perc... Read More about Acceptability of Lycra arm sleeve in people with sub-acute stroke: Patients', carers' and clinicians' perspectives.

Medium term results of the cementless Oxford mobile bearing medial unicompartmental knee replacement (2022)
Journal Article
Manara, J. R., Group, T. B. K., White, P., Bray, R., Davies, H., Eldridge, J., …Murray, J. (2023). Medium term results of the cementless Oxford mobile bearing medial unicompartmental knee replacement. European Journal of Orthopaedic Surgery and Traumatology, 33, 1335–1340. https://doi.org/10.1007/s00590-022-03289-w

Abstract Background Medial Unicompartmental Knee Replacement (UKR) has well-documented benefits over Total Knee Replace- ment in the treatment of anteromedial osteoarthritis of the knee. There has been an increasing move from cemented to cementl... Read More about Medium term results of the cementless Oxford mobile bearing medial unicompartmental knee replacement.