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The RNA revolution and cancer (2024)
Journal Article
Dlamini, Z., Ladomery, M., & Kahraman, A. (2024). The RNA revolution and cancer. Frontiers in Endocrinology, 15, Article 1422599. https://doi.org/10.3389/fendo.2024.1422599

RNA biology has revolutionized cancer understanding and treatment, especially in endocrine-related malignancies. This editorial highlights RNA's crucial role in cancer progression, emphasizing its influence on tumor heterogeneity and behavior. Proces... Read More about The RNA revolution and cancer.

Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3 (2024)
Journal Article
Williams, A., Cooper, E., Clark, B., Perry, L., Ponassi, M., Iervasi, E., …Ladomery, M. (2024). Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3. International Journal of Molecular Sciences, 25(10), Article 5380. https://doi.org/10.3390/ijms25105380

In a screen of over 200 novel pyrazole compounds, ethyl 1-(2-hydroxypentyl)-5-(3-(3- (trifluoromethyl) phenyl)ureido)-1H-pyrazole-4-carboxylate (named GeGe-3) has emerged as a potential anticancer compound. GeGe-3 displays potent anti-angiogenic pr... Read More about Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3.

Resistance to bacteriophage incurs a cost to virulence in drug-resistant Acinetobacter baumannii (2024)
Journal Article
Manley, R., Fitch, C., Francis, V., Temperton, I., Turner, D., Fletcher, J., …Temperton, B. (2024). Resistance to bacteriophage incurs a cost to virulence in drug-resistant Acinetobacter baumannii. Journal of Medical Microbiology, 73(5), Article 001829. https://doi.org/10.1099/jmm.0.001829

Introduction. Acinetobacter baumannii is a critical priority pathogen for novel antimicrobials (World Health Organization) because of the rise in nosocomial infections and its ability to evolve resistance to last resort antibiotics. A. baumannii is t... Read More about Resistance to bacteriophage incurs a cost to virulence in drug-resistant Acinetobacter baumannii.

Public involvement and public engagement: An example of convergent evolution? Findings from a conceptual qualitative review of patient and public involvement, and public engagement, in health and scientific research. (2024)
Journal Article
Wilkinson, C., Gibson, A., Biddle, M., & Hobbs, L. (2024). Public involvement and public engagement: An example of convergent evolution? Findings from a conceptual qualitative review of patient and public involvement, and public engagement, in health and scientific research. PEC Innovation, 4, Article 100281. https://doi.org/10.1016/j.pecinn.2024.100281

Patient and public involvement (PPI) in health research is now well-established, whilst science, technology, engineering and mathematics (STEM) research has shifted from a focus on science communication alone to public engagement (PE) within its rese... Read More about Public involvement and public engagement: An example of convergent evolution? Findings from a conceptual qualitative review of patient and public involvement, and public engagement, in health and scientific research..

Reading for Science: The use of scientific literary materials in primary schools (2024)
Presentation / Conference
Lewis, F., Edmonds, J., Carter, J., Alston, A., & Sargeant, S. (2024, March). Reading for Science: The use of scientific literary materials in primary schools. Paper presented at NARST 2024 Science Education for the rest of us, Denver, USA

Scientific literary materials (SLMs) present science content in genres such as narratives and poems as well as traditional non-fiction genres. SLMs have the potential to engage children and teachers who are non-science enthusiasts or specialists wit... Read More about Reading for Science: The use of scientific literary materials in primary schools.

In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy (2024)
Journal Article
Manohar, P., Loh, B., Turner, D., Tamizhselvi, R., Mathankumar, M., Elangovan, N., …Leptihn, S. (2024). In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy. Frontiers in Microbiology, 15, Article 1344962. https://doi.org/10.3389/fmicb.2024.1344962

Infections caused by Pseudomonas aeruginosa are becoming increasingly difficult to treat due to the emergence of strains that have acquired multidrug resistance. Therefore, phage therapy has gained attention as an alternative to the treatment of pseu... Read More about In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy.

Detection and quantitative microbial risk assessment of pathogenic Vibrio cholerae in a river used for drinking, domestic, fresh produce irrigation and recreational purposes (2024)
Journal Article
Ozochi, C. A., Okonkwo, C. C., Adukwu, E., Adukwu, E. C., Ujor, V. C., Enebe, M. C., & Chigor, V. N. (2024). Detection and quantitative microbial risk assessment of pathogenic Vibrio cholerae in a river used for drinking, domestic, fresh produce irrigation and recreational purposes. Discover Water, 4(1), Article 7. https://doi.org/10.1007/s43832-024-00059-z

Cholera infection results from the ingestion of water or food contaminated with toxigenic Vibrio cholerae. This study evaluated the occurrence of toxigenic V. cholerae in Asata River, Enugu Metropolis, Nigeria, and estimated V. cholerae infection ris... Read More about Detection and quantitative microbial risk assessment of pathogenic Vibrio cholerae in a river used for drinking, domestic, fresh produce irrigation and recreational purposes.

Understanding the impact of children's and young people's self-harm on parental well-being: a systematic literature review of qualitative and quantitative findings (2024)
Journal Article
Martin, F., Ferrey, A., Hobbs, L., Lascelles, K., van Even, S., & Oliver, T. (in press). Understanding the impact of children's and young people's self-harm on parental well-being: a systematic literature review of qualitative and quantitative findings. Child and Adolescent Mental Health, https://doi.org/10.1111/camh.12692

Background: Self-harm in children and young people is increasing. Parents are vital in supporting young people; however, parents may experience distress linked to the self-harm. Previous reviews have highlighted the emotional impact and need for info... Read More about Understanding the impact of children's and young people's self-harm on parental well-being: a systematic literature review of qualitative and quantitative findings.

Determination of the relative sensitivity of polyaniline inks and films to deprotonation by ammonia using UV–Vis spectroscopy (2023)
Journal Article
Udum, Y. A., Killard, A. J., & Wagner, M. (2024). Determination of the relative sensitivity of polyaniline inks and films to deprotonation by ammonia using UV–Vis spectroscopy. European Polymer Journal, 205, Article 112709. https://doi.org/10.1016/j.eurpolymj.2023.112709

The deprotonation behavior of conducting polymers such as polyaniline (PANI) is an important functional parameter in the design of novel printed electronic devices, particularly for sensors and energy storage. PANI can be fabricated into films from p... Read More about Determination of the relative sensitivity of polyaniline inks and films to deprotonation by ammonia using UV–Vis spectroscopy.

Bacteriophage taxonomy: A continually evolving discipline (2023)
Book Chapter
Adriaenssens, E. M., Turner, D., Lehman, S. M., Adriaenssens, E. M., Lehman, S. M., Kropinski, A. M., …Kropinski, A. M. (2023). Bacteriophage taxonomy: A continually evolving discipline. In J. Azeredo, & S. Sillankorva (Eds.), In Bacteriophage Therapy: From Lab to Clinical Practice (27-45). Humana Press. https://doi.org/10.1007/978-1-0716-3523-0_3

While taxonomy is an often underappreciated branch of science, it serves very important roles. Bacteriophage taxonomy has evolved from a discipline based mainly on morphology, characterized by the work of David Bradley and Hans-Wolfgang Ackermann, to... Read More about Bacteriophage taxonomy: A continually evolving discipline.

Comparison of the effects of antibiotics and essential oils against Acinetobacter baumannii in planktonic and biofilm conditions (2023)
Presentation / Conference
Salim, J., Nariapara, V., Adukwu, E., & Snook, A. (2023, November). Comparison of the effects of antibiotics and essential oils against Acinetobacter baumannii in planktonic and biofilm conditions. Poster presented at Annual Biomedical Research Conference for Minoritised Scientists, Phoenix, AZc, USA

Background: Acinetobacter baumannii is a common nosocomial pathogen causing pneumonia, bacteraemia, wound and urinary tract infections. Due to improper and frequent antibiotic use A. baumannii has become multi-drug resistant, the World Health Organi... Read More about Comparison of the effects of antibiotics and essential oils against Acinetobacter baumannii in planktonic and biofilm conditions.

Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells (2023)
Journal Article
Robson, J. L., Thorn, R. M. S., Williams, A. C., Collard, T. J., & Qualtrough, D. (2023). Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells. Scientific Reports, 13(1), Article 17291. https://doi.org/10.1038/s41598-023-44130-6

Colorectal cancer (CRC) is a significant global health burden with a rising incidence worldwide. Distinct bacterial populations are associated with CRC development and progression, and it is thought that the relationship between CRC and associated gu... Read More about Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells.

Is there a role for citizen science in death and dying research? (2023)
Journal Article
Wilkinson, C., Llewellyn, A., & McCabe, C. (2023). Is there a role for citizen science in death and dying research?. Frontiers in Public Health, 11, Article 1241239. https://doi.org/10.3389/fpubh.2023.1241239

The COVID-19 pandemic has brought conversations about death and dying to the fore in a way not experienced for generations. This raises questions around perceptions of death and dying; the role of healthcare and the community in care; and the use of... Read More about Is there a role for citizen science in death and dying research?.

Diversity and inclusion: Creating a culture of equity in the biosciences (2023)
Presentation / Conference
Adukwu, E. (2023, September). Diversity and inclusion: Creating a culture of equity in the biosciences. Presented at Bioscience Education Summit 2023, University of Liverpool, Liverpool, UK

Abstract: Globally, science remains exclusive and inequalities continue for minoritised communities in the UK, US and across the world. Access to learning resources, quality of learning experiences and graduate outcomes continues to impact minoritise... Read More about Diversity and inclusion: Creating a culture of equity in the biosciences.

Going circular: history, present, and future of circRNAs in cancer. (2023)
Journal Article
Pisignano, G., Michael, D. C., Pirlog, R., Visal, T. H., Ladomery, M., & Calin, G. A. (2023). Going circular: history, present, and future of circRNAs in cancer. Oncogene, 42, 2783–2800. https://doi.org/10.1038/s41388-023-02780-w

To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional molecules that have been shown to regulate gene expression transcriptionally a... Read More about Going circular: history, present, and future of circRNAs in cancer..